Compact system for in situ laser Doppler velocimetry of blood flow

Bou, Elise; Ly, Aliou; Roul, Julien; Llopis, Olivier; Vieu, Christophe; Cerf, Aline

doi:10.1364/boe.10.005862

Cited by 3 publications

(1 citation statement)

References 17 publications

(20 reference statements)

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“…Merits Limitations LSI [24,25] Noninvasive, high temporal resolution, provides 2D maps of blood flow, relatively simple Limited depth penetration, sensitive to motion artifacts Doppler-OCT [26][27][28] High resolution, can image microvasculature, provides depth-resolved measurements Limited field-of-view, relatively complex and expensive, sensitive to motion artifacts Laser Doppler velocimetry [29,30] Noncontact, able to measure velocity and flow rates, useful in fluid dynamics Limited to measuring flow in one point or very small area, sensitive to external disturbances Multiphoton microscopy [31,32] High spatial resolution, enhanced imaging depth, reduced photodamage (compared to conventional microscopy)…”

Section: Imaging Modalitymentioning

confidence: 99%

Advances in laser speckle imaging: From qualitative to quantitative hemodynamic assessment

Qureshi,

Allam,

et al. 2023

Journal of Biophotonics

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Laser speckle imaging (LSI) techniques have emerged as a promising method for visualizing functional blood vessels and tissue perfusion by analyzing the speckle patterns generated by coherent light interacting with living biological tissue. These patterns carry important biophysical tissue information including blood flow dynamics. The non‐invasive, label‐free, and wide‐field attributes along with relatively simple instrumental schematics make it an appealing imaging modality in pre‐clinical and clinical applications. The review outlines the fundamentals of speckle physics and the three categories of LSI techniques based on their degree of quantification: qualitative semi‐quantitative and quantitative. Qualitative LSI produces microvascular maps by capturing speckle contrast variations between blood vessels containing moving red blood cells and the surrounding static tissue. Semi‐quantitative techniques provide a more accurate analysis of blood flow dynamics by accounting for the effect of static scattering on spatiotemporal parameters. Quantitative LSI such as optical speckle image velocimetry (OSIV) provides quantitative flow velocity measurements which is inspired by the particle image velocimetry in fluid mechanics. Additionally, discussions regarding the prospects of future innovations in LSI techniques for optimizing the vascular flow quantification with associated clinical outlook are presented.This article is protected by copyright. All rights reserved.

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Section: Imaging Modalitymentioning

confidence: 99%

Advances in laser speckle imaging: From qualitative to quantitative hemodynamic assessment

Qureshi,

Allam,

et al. 2023

Journal of Biophotonics

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Angular velocimetry for fluid flows: an optical sensor using structured light and machine learning

et al. 2021

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Most velocimetry approaches for fluid flows measure linear components of the velocity vector; yet, the angular velocity components, particularly at small scales in turbulent flows, also need to be resolved to study energy transfer and other important flow characteristics. Here, we detail an optical sensor approach to determine a component of the angular velocity vector. This approach uses beams of structured light and a machine learning-based analysis. We discuss the methodology to train the machine learning model and test it in experimentally validated simulations. This approach represents an interesting new direction for fluid flow velocimetry which may be extended to sense other flow parameters by selecting different light structures.

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Orbital angular momentum-based dual-comb interferometer for ranging and rotation sensing

et al. 2022

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We present a dual-comb interferometer capable of measuring both the range to a target as well as the target’s transverse rotation rate. Measurement of the transverse rotation of the target is achieved by preparing the probe comb with orbital angular momentum and measuring the resultant phase shift between interferograms, which arises from the rotational Doppler shift. The distance to the target is measured simultaneously by measuring the time-of-flight delay between the target and reference interferogram centerbursts. With 40 ms of averaging, we measure rotation rates up to 313 Hz with a precision reaching 1 Hz. Distances are measured with an ambiguity range of 75 cm and with a precision of 5.9 µm for rotating targets and 400 nm for a static target. This is the first dual-comb ranging system capable of measuring transverse rotation of a target. This technique has many potential terrestrial and space-based applications for lidar and remote sensing systems.

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Compact system for in situ laser Doppler velocimetry of blood flow

Cited by 3 publications

References 17 publications

Advances in laser speckle imaging: From qualitative to quantitative hemodynamic assessment

Advances in laser speckle imaging: From qualitative to quantitative hemodynamic assessment

Angular velocimetry for fluid flows: an optical sensor using structured light and machine learning

Orbital angular momentum-based dual-comb interferometer for ranging and rotation sensing

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