Compact supercontinuum sources and their biomedical applications

Labruyère, Alexis; Tonello, Alessandro; Couderc, Vincent; Huss, Guillaume; Leproux, Philippe

doi:10.1016/j.yofte.2012.08.003

Cited by 107 publications

(36 citation statements)

References 16 publications

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“…[6][7][8][9] Among the reported SC light sources, the sub-nanosecond fiber-based system is one of the most appropriate solutions from the viewpoints of compactness, cost-effectiveness and user-friendliness. It is widely recognized as the compact and low-cost "white-light laser".…”

Section: Introductionmentioning

confidence: 99%

Multimodal Imaging of Living Cells with Multiplex Coherent Anti-stokes Raman Scattering (CARS), Third-order Sum Frequency Generation (TSFG) and Two-photon Excitation Fluorescence (TPEF) Using a Nanosecond White-light Laser Source

et al. 2015

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The subnanosecond "white-light laser" source has been applied to multimodal, multiphoton, and multiplex spectroscopic imaging (M 3 spectroscopic imaging) with coherent anti-Stokes Raman scattering (CARS), third-order sum frequency generation (TSFG), and two-photon excitation fluorescence (TPEF). As the proof-of-principle experiment, we performed simultaneous imaging of polystyrene beads with TSFG and TPEF. This technique is then applied to live cell imaging. Mouse L929 fibroblastic cells are clearly visualized by CARS, TSFG, and TPEF processes. M 3 spectroscopic imaging provides various and unique cellular information with different image contrast based on each multiphoton process.

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Section: Introductionmentioning

confidence: 99%

Multimodal Imaging of Living Cells with Multiplex Coherent Anti-stokes Raman Scattering (CARS), Third-order Sum Frequency Generation (TSFG) and Two-photon Excitation Fluorescence (TPEF) Using a Nanosecond White-light Laser Source

et al. 2015

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“…The supercontinuum light source has been used in a wide range of applications, including time-resolved multiplex coherent anti-Stokes Raman scattering [11][12][13]. Recently, the supercontinuum light source is being used for a number of biomedical applications due to its compact size, sturdiness and spectral range [14,15]. We report on the use of a NIR supercontinuum (SC) laser light source utilizing wavelengths in the second and third NIR optical windows to image more deeply through tissue.…”

Section: Introductionmentioning

confidence: 99%

Imaging of tissue using a NIR supercontinuum laser light source with wavelengths in the second and third NIR optical windows

Sordillo

Lindwasser

Budansky

et al. 2015

Optical Tomography and Spectroscopy of Tissue XI

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Supercontinuum light (SC) at wavelengths in the second (1,100 nm to 1,350 nm) and third (1,600 nm to 1,870 nm) NIR optical windows can be used to improve penetration depths of light through tissue and produce clearer images. Image quality is increased due to a reduction in scattering (inverse wavelength power dependence 1/λ n , n≥1). We report on the use of a compact Leukos supercontinuum laser (model STM-2000-IR), which utilizes the spectral range from 700 nm to 2,400 nm and offers between 200 -500 microwatt/nm power in the second and third NIR windows, with an InGaAs detector to image abnormalities hidden beneath thick tissue.

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“…T HE possibility of tailoring the dispersive properties in photonic crystal fibers (PCFs) paves the way to the development of different types of supercontinuum (SC) sources for various applications, including for example optical coherence tomography, broadband spectroscopy or coherent anti-Stokes Raman scattering (CARS) microspectroscopy [1], [2]. A strong interaction between nonlinear and dispersive properties of PCFs allows controlling useful SC parameters, such as width, flatness and coherence [3]- [6].…”

Section: Introductionmentioning

confidence: 99%

Experimental Investigation of Supercontinuum Generation in Photonic Crystal Fibers Pumped With Sub-ns Pulses

Holdynski

Napierała

Mergo

et al. 2015

J. Lightwave Technol.

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We experimentally investigate a supercontinuum generation in a series of photonic crystal fibers pumped with sub-ns pulses. The fibers are designed to have zero dispersion wavelengths close to 1064 nm, but they differ with respect to the lattice constant and air hole size. We focus on the supercontinuum generation mechanism and on the shape of spectra generated with the use of these photonic crystal fibers. A comprehensive study on the influence of the fiber structural parameters on the supercontinuum outcome indicates how to tailor these parameters for specific application where particular spectral characteristics are desired.

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Compact supercontinuum sources and their biomedical applications

Cited by 107 publications

References 16 publications

Multimodal Imaging of Living Cells with Multiplex Coherent Anti-stokes Raman Scattering (CARS), Third-order Sum Frequency Generation (TSFG) and Two-photon Excitation Fluorescence (TPEF) Using a Nanosecond White-light Laser Source

Multimodal Imaging of Living Cells with Multiplex Coherent Anti-stokes Raman Scattering (CARS), Third-order Sum Frequency Generation (TSFG) and Two-photon Excitation Fluorescence (TPEF) Using a Nanosecond White-light Laser Source

Imaging of tissue using a NIR supercontinuum laser light source with wavelengths in the second and third NIR optical windows

Experimental Investigation of Supercontinuum Generation in Photonic Crystal Fibers Pumped With Sub-ns Pulses

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