Compact point-of-care system for clinical diagnostics

Kemmler, Manuel; Koger, Birgit; Sulz, Gerd; Sauer, Ursula; Schleicher, Erwin; Preininger, Claudia; Brandenburg, Albrecht

doi:10.1016/j.snb.2008.08.043

Cited by 25 publications

(15 citation statements)

References 24 publications

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“…Integrated optical waveguides (IOWs) are prepared by depositing a very thin layer, usually in the order of the light wavelength or less, of a high refractive index material (usually metal oxides such as SiO 2 , TiO 2 , Ta 2 O 5 , or Nb 2 O 5 ) on a glass substrate [29e31]. The sensitivity of IOWs has shown to be much higher in fluorescence based studies than for IRE-based waveguides, however they are more difficult to prepare and light coupling into the optical waveguide is more difficult requiring the assistance of prism or grating arrangements [29,32,33].…”

Section: Light Guiding In Optical Waveguides and Biosensor Configuratmentioning

confidence: 99%

Fluorescence based fiber optic and planar waveguide biosensors. A review

Benito‐Peña

Valdés

Glahn-Martínez

et al. 2016

Analytica Chimica Acta

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The application of optical biosensors, specifically those that use optical fibers and planar waveguides, has escalated throughout the years in many fields, including environmental analysis, food safety and clinical diagnosis. Fluorescence is, without doubt, the most popular transducer signal used in these devices because of its higher selectivity and sensitivity, but most of all due to its wide versatility. This paper focuses on the working principles and configurations of fluorescence-based fiber optic and planar waveguide biosensors and will review biological recognition elements, sensing schemes, as well as some major and recent applications, published in the last ten years. The main goal is to provide the reader a general overview of a field that requires the joint collaboration of researchers of many different areas, including chemistry, physics, biology, engineering, and material science.

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Section: Light Guiding In Optical Waveguides and Biosensor Configuratmentioning

confidence: 99%

Fluorescence based fiber optic and planar waveguide biosensors. A review

Benito‐Peña

Valdés

Glahn-Martínez

et al. 2016

Analytica Chimica Acta

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“…In the device described in [38], based on a fluorescence microarray, the format is a sandwich immunoassay. The assay processing and read out is done automated by the system which consists of the bioassay, the read out based on planar waveguide technique and a fluidic set-up.…”

Section: Poct Devicesmentioning

confidence: 99%

Optical Biosensing in Medical and Clinical Diagnostics

Baldini

Giannetti

Tombelli

et al. 2013

Photonics for Safety and Security

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The novel developments in the area of optical sensors for the detection of chemical and biochemical analytes in medical and clinical diagnostics are described. In particular, the new progress in the field of optical nanosensors for intracellular applications is described, with particular attention to oligonucleotide optical switches, in which the "nanodevice" can work as intracellular nanosensor and drug at the same time. Also point of care testing devices for novel clinical applications in the area of sepsis and of detection of immunosuppressants in transplanted patients are described as well as the new developments in the field of invasive optical fiber sensors for gastroesophageal apparatus.

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“…fluorescence (TIRF), which is well suited to the detection of fluorophores bound to surfaces, was also demonstrated [19,20]. The TIRF detection system is not recent, but it was applied in a pointof-care device, taking advantage of the reduction of background signal and the low amount of f luorophore detection due to TIRF.…”

Section: Recent Advances In Multiplex Immunoassaysmentioning

confidence: 99%

Recent Advances in Multiplex Immunoassays

2012

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The present review reports on the lastest developments in multiplex immunoassays. The selected examples are classified through their detection strategy (fluorescence, chemiluminescence, colorimetry or labeless) and their assay format (standard microtiter plate, polymeric membranes and glass slides). Finally, the degree of integration in a complete system, incorporating fluid handling and detection was also taken into account.

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Compact point-of-care system for clinical diagnostics

Cited by 25 publications

References 24 publications

Fluorescence based fiber optic and planar waveguide biosensors. A review

Fluorescence based fiber optic and planar waveguide biosensors. A review

Optical Biosensing in Medical and Clinical Diagnostics

Recent Advances in Multiplex Immunoassays

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