“…2,8,10 Phagocytosis also appears to be impaired. 10 In general, people with DS have a high incidence of mortality caused by infection, 5,10 increased incidence of malignancies such as leukemia, and are more likely to develop autoimmune conditions such as thyroiditis and alopecia areata. 2 DS is also associated with accelerated aging and an increased incidence of acne vulgaris, anetoderma, cheilitis, cutis marmorata, elastosis perforans serpiginosa, fissured and geographic tongue, onychomycosis, palmoplantar hyperkeratosis, pityriasis rubra pilaris, psoriasis, seborrheic dermatitis, syringoma, tinea pedis, and xerosis.…”