“…It has variable phenotypes, and multiple malformations and mental retardation may be present. DS has been associated with several dermatoses, such as abnormalities of the tongue, cheilitis, xerosis, alopecia areata, palmoplantar hyperkeratosis, keratosis pilaris, syringomas, milium-like skin calcinosis, elastosis perforans serpiginosa, trichotillomania, vitiligo/leukoderma, livedo reticularis, seborrheic dermatitis, early aging, atopic dermatitis and infections (folliculitis, scabies, onychomycosis, tinea pedis) [16,17,18,19,20]. A tendency to obesity in individuals with DS is well-known, both in childhood and adulthood with a greater prevalence among females [21].…”