Dermatological Manifestations of Down's Syndrome

Abstract

Background: Down's syndrome (DS) is an extensively researched congenital condition characterized by mental retardation and distinct physical features. The cutaneous manifestations of DS are numerous, yet they seldom receive appropriate attention.Objective: To review the dermatological conditions associated with DS.Methods: A review of the medical literature.Results: DS is associated with an increased incidence of numerous dermatological conditions, some of which may be related to an immunological deficiency.Conclusion: Along with the importance of understanding the physical and psychosocial aspects of DS, an appreciation of the dermatological manifestations of this condition is integral to comprehensive medical care.

Prevalence of Acne Vulgaris in Patients with Down Syndrome

“…To our knowledge, this is the first report of a possible ‘protective’ role of trisomy 21 for the development of acne in puberty. This is in discrepancy with the previous literature, where an increased incidence of acne in DS has been postulated [17]. In addition, the prevalence of acne was higher in males (76.2%) than in females (47.6%) with DS.…”

“…It has variable phenotypes, and multiple malformations and mental retardation may be present. DS has been associated with several dermatoses, such as abnormalities of the tongue, cheilitis, xerosis, alopecia areata, palmoplantar hyperkeratosis, keratosis pilaris, syringomas, milium-like skin calcinosis, elastosis perforans serpiginosa, trichotillomania, vitiligo/leukoderma, livedo reticularis, seborrheic dermatitis, early aging, atopic dermatitis and infections (folliculitis, scabies, onychomycosis, tinea pedis) [16,17,18,19,20]. A tendency to obesity in individuals with DS is well-known, both in childhood and adulthood with a greater prevalence among females [21].…”

Vitiligo vulgaris in a patient of progeria

“…Vitiligo has been associated with various immunological and endocrine disorders as well as other genodermatoses like Down's syndrome. [5] There has been no clear cut explanation for the association. We report this case because of 2 unusual things, first the age of the patient.…”

Down Syndrome and Delayed Occurrence of Acne

“…In this setting, an increased incidence of acne has been associated with DS in some previous publications [1] . Some data may support such an association.…”

“…Down syndrome (DS) is associated with an increased incidence of skin diseases which may cause further psychosocial disability in affected patients [1,2] . In this setting, an increased incidence of acne has been associated with DS in some previous publications [1] .…”