Comorbidity and familial aggregation of back/neck pain in the NIMH Family Study of Affective Spectrum Disorders

Stapp, Emma K.; Cui, Lihong; Guo, Wei; Paksarian, Diana; Merikangas, Kathleen R.

doi:10.1016/j.jpsychores.2022.110927

Cited by 3 publications

(5 citation statements)

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“…In support of this contention, the negative correlation between chronic low back pain and depression was no longer significant when adjusting for power distance and collectivism ( r = -.11, p = .253). Given the evidence of a genetic link between depression and both these types of pain ( 14 ), it is possible that cultural factors may interact with an innate genetic vulnerability, leading to phenotypic variations in which some patients present predominantly with depression and others with chronic back or neck pain. This result highlights the need for a more culturally sensitive assessment of depression in patients presenting with a primary complaint of chronic pain, particularly in low- and middle-income countries.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, these two types of pain frequently co-occur: it has been found that around 30%–55% of patients with chronic low back pain also experience neck pain ( 13 ). Chronic back and neck pain also show evidence of familial aggregation, which suggests that they may share genetic risk factors ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

“…Owing to these limitations, there is also a significant amount of interest in the role of psychological and social factors in the onset, persistence, and outcome of chronic low back and neck pain. From a psychological perspective, both these conditions appear to be genetically linked to depression ( 14 ). Depressive disorders are more common in patients with these disorders than in the general population ( 27 , 28 ), and depression has been found to predict functional outcomes in these patients ( 29 , 30 ).…”

Section: Introductionmentioning

confidence: 99%

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The influence of cultural and religious factors on cross-national variations in the prevalence of chronic back and neck pain: an analysis of data from the global burden of disease 2019 study

Rajkumar

2023

Front. Pain Res.

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IntroductionLow back pain and neck pain are among the most commonly reported forms of chronic pain worldwide, and are associated with significant distress, disability and impairment in quality of life. Though these categories of pain can be analyzed and treated from a biomedical perspective, there is evidence that they are both related to psychological variables such as depression and anxiety. The experience of pain can be significantly influenced by cultural values. For example, cultural beliefs and attitudes can influence the meaning attached to the experience of pain, the responses of others to a sufferer's pain, and the likelihood of seeking medical care for particular symptoms. Likewise, religious beliefs and practices can influence the both experience of pain and the responses to it. These factors have also been associated with variations in the severity of depression and anxiety.MethodsIn the current study, data on the estimated national prevalence of both low back pain and neck pain, obtained from the 2019 Global Burden of Disease Study (GBD 2019), is analyzed in relation to cross-national variations in cultural values, as measured using Hofstede's model (n =115 countries) and in religious belief and practice, based on the most recent Pew Research Center survey (n = 105 countries). To address possible confounding factors, these analyses were adjusted for variables known to be associated with chronic low back or neck pain, namely smoking, alcohol use, obesity, anxiety, depression and insufficient physical activity.ResultsIt was found that the cultural dimensions of Power Distance and Collectivism were inversely correlated with the prevalence of chronic low back pain, and Uncertainty Avoidance was inversely correlated with the prevalence of chronic neck pain, even after adjustment for potential confounders. Measures of religious affiliation and practice were negatively correlated with the prevalence of both conditions, but these associations were not significant after adjusting for cultural values and confounders.DiscussionThese results highlight the existence of meaningful cross-cultural variations in the occurrence of common forms of chronic musculoskeletal pain. Psychological and social factors that could account for these variations are reviewed, along with their implications for the holistic management of patients with these disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The influence of cultural and religious factors on cross-national variations in the prevalence of chronic back and neck pain: an analysis of data from the global burden of disease 2019 study

Rajkumar

2023

Front. Pain Res.

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“…Future research should examine the utility of individual octants or dimensions in contrast to data‐reducing approaches such as scales or common latent factors in understanding differences across mood disorders (Bos et al., 2022 ; Taylor et al., 2021 ) and general affective disturbance and risk in nonclinical samples (Sperry & Kwapil, 2022 ; Trampe et al., 2015 ). Finally, we did not examine what is driving these fluctuations and thus cannot determine whether they are stochastic, innate, or sparked by health behaviors or comorbidities, for example (Alloy & Abramson, 2010 ; Johnson et al., 2012 ; Lewis et al., 2022 ; Pemberton & Fuller Tyszkiewicz, 2016 ; Quick et al., 2022 ; Stapp et al., 2022 ). Our perspective is that there is inherent worth in understanding these characteristics and dynamics as they are, irrespective of putative cause.…”

Section: Discussionmentioning

confidence: 99%

Specificity of affective dynamics of bipolar and major depressive disorder

et al. 2023

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ObjectiveHere, we examine whether the dynamics of the four dimensions of the circumplex model of affect assessed by ecological momentary assessment (EMA) differ among those with bipolar disorder (BD) and major depressive disorder (MDD).MethodsParticipants aged 11–85 years (n = 362) reported momentary sad, anxious, active, and energetic dimensional states four times per day for 2 weeks. Individuals with lifetime mood disorder subtypes of bipolar‐I, bipolar‐II, and MDD derived from a semistructured clinical interview were compared to each other and to controls without a lifetime history of psychiatric disorders. Random effects from individual means, inertias, innovation (residual) variances, and cross‐lags across the four affective dimensions simultaneously were derived from multivariate dynamic structural equation models.ResultsAll mood disorder subtypes were associated with higher levels of sad and anxious mood and lower energy than controls. Those with bipolar‐I had lower average activation, and lower energy that was independent of activation, compared to MDD or controls. However, increases in activation were more likely to perpetuate in those with bipolar‐I. Bipolar‐II was characterized by higher lability of sad and anxious mood compared to bipolar‐I and controls but not MDD. Compared to BD and controls, those with MDD exhibited cross‐augmentation of sadness and anxiety, and sadness blunted energy.ConclusionBipolar‐I is more strongly characterized by activation and energy than sad and anxious mood. This distinction has potential implications for both specificity of intervention targets and differential pathways underlying these dynamic affective systems. Confirmation of the longer term stability and generalizability of these findings in future studies is necessary.

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“… 59 Emma K and her colleagues found that common familial risk factors underlying back/neck pain with MDD, whereas there was within-individual comorbidity of bipolar with back/neck pain. 60 The previous literature shows that bipolar disorder or affective disorders is related to NP. Therefore, exploring potential targets and mechanisms of neuralgia is helpful for the diagnosis, occurrence and development of NP, bipolar disorder and affective disorders.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Ferroptosis-Related Molecular Subtypes with Immune Infiltrations in Neuropathic Pain

Bi¹,

Wang²,

Guo³

et al. 2022

JPR

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Background Neuropathic pain (NP) caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition that has a major impact on quality of life. However, NP pathogenesis remains unclear. The purpose of this study was to identify differentially expressed genes (DEGs) and specific and meaningful gene targets for the diagnosis and treatment of NP. Methods Data from rat spinal nerve ligations and the sham group were downloaded from the Gene Expression Omnibus (GEO) database. Based on the single-sample gene set enrichment analysis (ssGSEA) method, 29 immune gene sets were identified in each sample, and these samples were correlated with the immune infiltration phenotype. LASSO regression modeling was used to screen key genes to identify diagnostic gene markers. According to GSEA and GSVA, NP is concentrated in a large number of immune-related pathways and genes. Additionally, we used the DGIdb database and correlation test to construct gene-drug and transcription factor interaction networks for differentially expressed genes relevant to NP-related ferroptosis. We used WGCNA to identify gene co-expression modules of NP, and explored the relationship between gene networks and phenotypes. Finally, we crossed core genes with diagnostic markers and analyzed gene correlation with molecular subtypes and immune cells. Results We identified 224 DEGs, including 191 upregulated genes and 33 downregulated genes. APC co-stimulation, CCR, cytolytic activity, humid-promoting, neutrophils, NK cells, and RGS4, CXCL2, DRD4 and other 7 genes related to ferroptosis were involved in NP development. Key genes of RGS4 and HIF−1 signaling pathway were screened. Conclusion This study contributes to our understanding of the neuroimmune mechanism of neuropathic pain, provides a reference for NP biomarkers and drug targets. Ferroptosis may be the next research direction to explore NP mechanism.

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Comorbidity and familial aggregation of back/neck pain in the NIMH Family Study of Affective Spectrum Disorders

Cited by 3 publications

References 73 publications

The influence of cultural and religious factors on cross-national variations in the prevalence of chronic back and neck pain: an analysis of data from the global burden of disease 2019 study

The influence of cultural and religious factors on cross-national variations in the prevalence of chronic back and neck pain: an analysis of data from the global burden of disease 2019 study

Specificity of affective dynamics of bipolar and major depressive disorder

Characterization of Ferroptosis-Related Molecular Subtypes with Immune Infiltrations in Neuropathic Pain

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