Comorbidities in rheumatoid arthritis

Dougados, Maxime

doi:10.1097/bor.0000000000000267

Cited by 108 publications

(75 citation statements)

References 48 publications

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“…Lung disease, certain malignancies, osteoporosis, and psychiatric disorders have all been associated with RA [2, 8, 11-13]. Apart from the considerable disease burden of RA, patients often are affected by concomitant comorbidities, many of which are age dependent [2].…”

Section: Introductionmentioning

confidence: 99%

Stroke among Rheumatoid Arthritis Patients: Does Age Matter? A Real-Life Study

et al. 2017

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Background/Aims: Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune disease that affects the joints and it is known to be associated with cardiovascular morbidity. However, the association between RA and stroke among different age groups has not been explored. The objective of our study was to evaluate the association between RA and stroke in different age strata. Methods: Cross-sectional study, utilizing the database of Israel’s largest healthcare provider. The proportion of stroke was compared between patients diagnosed with RA and age- and gender-matched controls. The study sample was divided into 2 age groups: young (≤65 years) and elderly (>65 years). Multivariable analysis was performed using logistic regression. Results: The study included 11,782 RA patients and 57,973 age- and gender-matched controls. RA patients, primarily young, had more cardiovascular risk factors than controls. Stroke rates were significantly elevated among young RA patients in comparison with controls (3.74 vs. 2.20%, respectively, p < 0.001). In multivariate analysis, RA was found to be independently associated with stroke (OR 1.18, 95% CI 1.09–1.28). Conclusion: RA is independently associated with stroke, especially among RA patients under 65 years, for whom cardiovascular risk factors were more prominent. Physicians should advise RA patients to manage their risk factors strictly.

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Section: Introductionmentioning

confidence: 99%

Stroke among Rheumatoid Arthritis Patients: Does Age Matter? A Real-Life Study

et al. 2017

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“…Increased osteoclastogenesis promotes joint destruction and early onset osteoporosis in patients with RA [20]. Treatment of early onset osteoporosis is important in these patients, because their chronic in ammatory status (due to long-term use of glucocorticoids) can exacerbate osteoporosis [38]. Osteoclasts are the main effector cells in osteoporosis, and a therapeutic modality that acts on both arthritis and osteoporosis would likely be effective for patients RA.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells

Jhun¹,

Min

Ryu³

et al. 2020

Preprint

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Background: To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells. Methods: We evaluated whether L. sakei reduced the severity of collagen-induced arthritis (CIA) and modulated interleukin (IL)-17 and IL-10 levels, as well as whether it affected the differentiation of CD4 + T cells and regulatory B cells. We evaluated osteoclastogenesis after culturing bone marrow-derived mononuclear cells with L. sakei. Results: The differentiation of T helper 17 cells and the serum level of IL-17 were suppressed by L. sakei in both human peripheral blood mononuclear cells and mouse splenocytes. The serum level of IL-10 was significantly increased in the L. sakei -treated group, whereas the regulatory T cell population was unchanged. The population of regulatory B cells significantly increased the in L. sakei -treated group. Oral administration of L. sakei reduced the arthritis incidence and score in mice with CIA. Finally, osteoclastogenesis and the mRNA levels of osteoclast-related genes were suppressed in the L. sakei -treated group. Conclusion: L. sakei exerted an anti-inflammatory effect in an animal model of RA, regulated Th17 and regulatory B cell differentiation, and suppressed osteoclastogenesis. Our findings suggest that L. sakei has therapeutic potential for RA.

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“…Rheumatoid arthritis (RA) is a chronic systemic disease, which is characterized as a symmetric polyarticular inflammation of synovia-lined joints and progressive loss of articular cartilage and subchondral bone (Bilthariya et al, 2015;Gasparyan et al, 2011;Dougados, 2016). Although the exact molecular pathogenesis of RA remains elucidated, evidence suggests that the pathogenesis of RA was associated with the imbalance of cellular and humoral immunity, which were mediated by diverse inflammatory cells such as lymphocytes and synovial cells via various signal transduction cascades involving the signal transduction of G protein-adenylyl cyclase-3 0 ,5 0 -cyclic adenosine monophosphate (cAMP) and Ras-mitogen-associated protein kinases (Findlay and Haynes, 2005;Chang et al, 2009;Bollmann, 2012;Mauri and Ehrenstein, 2007;Bae and Park, 2016;Loetscher, 2005;Tanaka, 2005;Chen, 2010).…”

Section: Introductionmentioning

confidence: 99%

Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis

et al. 2017

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Geniposide (GE), an iridoid glycoside compound purified from Gardenia jasminoides Ellis, has antiinflammatory and other pharmacological effects, but its mechanism of actions on rheumatoid arthritis (RA) have not been clarified. The purpose of this article was to investigate the pharmacological effects of GE on collagen-induced arthritis (CIA) rats and its feasible mechanisms. Collagen-induced arthritis was induced by injection of chicken type II collagen emulsion. The rats were orally administered with GE (33, 66, and 132 mg/kg) from days 14 to 30 after immunization. The histological examination showed that GE could attenuate histopathologic changes of mesenteric lymph node (MLN) in CIA rats. Geniposide inhibited the production of Interleukin 6 (IL-6) and IL-17, while promoting the production of IL-4 and transforming growth factor-beta 1 in MLN lymphocytes (MLNLs). Moreover, the proliferation capability of MLNLs was increased after the administration of GE. In addition, the treatment with GE in vivo decreased the expressions of P-Raf, P-MEK, and P-Erk1/2 in MLNLs. These results may highlight the antiinflammatory effects and possible mechanisms of GE in MLNLs of RA. Copyright © 2017 John Wiley & Sons, Ltd.

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Comorbidities in rheumatoid arthritis

Cited by 108 publications

References 48 publications

Stroke among Rheumatoid Arthritis Patients: Does Age Matter? A Real-Life Study

Stroke among Rheumatoid Arthritis Patients: Does Age Matter? A Real-Life Study

Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells

Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis

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