Comorbid anxiety and depression: Opposing effects on the electrocortical processing of negative imagery in a focal fear sample

Bauer, Elizabeth; MacNamara, Annmarie

doi:10.1002/da.23160

Cited by 11 publications

(10 citation statements)

References 45 publications

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“…Crucially, participants described these images as 'snapshots' of an intrusive memory that were coupled with a sense of 'nowness', and physical and emotional re-experiencing. Similarly, in a sample with comorbid anxiety and depression, those with generalised anxiety disorder (GAD) showed increased neural processing of negative imagery when controlling for depression (Bauer & MacNamara, 2021). Together, the processes described here closely parallel the grounded cognitive processes of situated conceptualisations and simulations discussed above for the domains of appetitive behaviour.…”

Section: A Grounded Cognition Perspective On Regulating Negative Ment...supporting

confidence: 61%

Grounding Motivation for Behaviour Change

Papies¹,

Barsalou²,

Claassen³

et al. 2022

Preprint

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Many of the key problems humans are facing today result from desires, habits, and social norms impeding behaviour change. Here, we apply a grounded cognition perspective to these phenomena, suggesting that simulating the consequences of one’s actions plays a key role in them. We first describe the grounded cognition theory of desire and motivated behaviour, and present evidence on how consumption and reward simulations underlie people’s representation of appetitive stimuli and guide motivated behaviour. Then, we discuss how the theory can be used to understand the effects of habits, social norms, and various self-regulation strategies. We suggest conceptualising behaviour change as overcoming the simulations of hedonic and social reward that favour existing habits and behaviours, and as updating situated representations of motivated behaviours in their social context. We discuss how this perspective can help us understand the challenges that people experience in initiating and repeating new behaviours, and in high-impact decision making in the face of the status quo. In order to move beyond the socially sanctioned, habitual behaviours that currently threaten human and planetary health, we must understand what motivates them, and how this motivation can be harnessed for the greater good.

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Section: A Grounded Cognition Perspective On Regulating Negative Ment...supporting

confidence: 61%

Grounding Motivation for Behaviour Change

Papies¹,

Barsalou²,

Claassen³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The LHb mediates negative emotions and is most widely studied in cases of depression mainly due to its abnormal excitation. Indeed, anxiety and depression are often concomitant ( 30 ), and trigeminal neuralgia mice show both anxiety and depression after model establishment ( 19 , 31 ). The LHb is the only brain region that is observed to be abnormally hyperactive in depressed animals ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Tachykinin receptor 3 in the lateral habenula alleviates pain and anxiety comorbidity in mice

Zhang

Chen

et al. 2023

Front. Immunol.

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The coexistence of chronic pain and anxiety is a common clinical phenomenon. Here, the role of tachykinin receptor 3 (NK3R) in the lateral habenula (LHb) in trigeminal neuralgia and in pain-associated anxiety was systematically investigated. First, electrophysiological recording showed that bilateral LHb neurons are hyperactive in a mouse model of trigeminal neuralgia made by partial transection of the infraorbital nerve (pT-ION). Chemicogenetic activation of bilateral LHb glutamatergic neurons in naive mice induced orofacial allodynia and anxiety-like behaviors, and pharmacological activation of NK3R in the LHb attenuated allodynia and anxiety-like behaviors induced by pT-ION. Electrophysiological recording showed that pharmacological activation of NK3R suppressed the abnormal excitation of LHb neurons. In parallel, pharmacological inhibition of NK3R induced orofacial allodynia and anxiety-like behavior in naive mice. The electrophysiological recording showed that pharmacological inhibition of NK3R activates LHb neurons. Neurokinin B (NKB) is an endogenous high-affinity ligand of NK3R, which binds NK3R and activates it to perform physiological functions, and further neuron projection tracing showed that the front section of the periaqueductal gray (fPAG) projects NKB-positive nerve fibers to the LHb. Optogenetics combined with electrophysiology recordings characterize the functional connections in this fPAG NKB → LHb pathway. In addition, electrophysiological recording showed that NKB-positive neurons in the fPAG were more active than NKB-negative neurons in pT-ION mice. Finally, inhibition of NKB release from the fPAG reversed the analgesic and anxiolytic effects of LHb Tacr3 overexpression in pT-ION mice, indicating that fPAG NKB → LHb regulates orofacial allodynia and pain-induced anxious behaviors. These findings for NK3R suggest the cellular mechanism behind pT-ION in the LHb and suggest that the fPAG NKB → LHb circuit is involved in pain and anxiety comorbidity. This previously unrecognized pathway might provide a potential approach for relieving the pain and anxiety associated with trigeminal neuralgia by targeting NK3R.

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“…Moreover, depressed individuals have mood-congruent internal mental representations or schemas (Beck, 1967), and have been supported by numerous studies exploring the neural response of depressed individuals to external emotional stimuli (Benau et al, 2019;Zhou et al, 2021). However, emotional imagery, a mental representations of imagined emotional events or stimuli, might more closely mirror the experiences of individuals with mood disorders (Bauer & MacNamara, 2021). Therefore, exploring the neural correlates of emotional imagery in depressed individuals may contribute to further understand the underlying mechanisms of depression.…”

Section: Introductionmentioning

confidence: 94%

“…Most previous laboratory studies have employed external stimuli such as negative pictures and words to evoke negative emotion (Benau et al, 2019;Nikolin et al, 2022). However, it is possible that imagined or recalled negative scenarios are more closely to the experience of individuals with mood disorders (Bauer & MacNamara, 2021). Several studies have demonstrated the potential to elicit LPP responses to emotional imagery in both healthy and clinical samples (Bauer & MacNamara, 2021;MacNamara, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…However, it is possible that imagined or recalled negative scenarios are more closely to the experience of individuals with mood disorders (Bauer & MacNamara, 2021). Several studies have demonstrated the potential to elicit LPP responses to emotional imagery in both healthy and clinical samples (Bauer & MacNamara, 2021;MacNamara, 2018). For instance, healthy individuals exhibited enhanced LPP responses to emotional imagery relative to neutral imagery (MacNamara, 2018), as well as larger LPP responses to positive imagery versus negative imagery (Marmolejo-Ramos et al, 2015;Suess & Rahman, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Negative bias for sad imagery in depression: An ERP study

Xiong²,

Zhou³

et al. 2023

Preprint

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Individuals with depression experience more negative imagery and less vivid positive imagery, and the late positive potential (LPP) is considered as a viable biomarker for negative attentional and memory biases in depression; however, the LPP response to emotional imagery in depressed individuals remains unclear. This study aims to investigate neural response to emotional imagery in depressed individuals. ERPs were recorded from 40 depressed participants and 44 healthy controls during the encoding-imagery task. Depressed participants scored significantly lower in the valence rating of sad and neutral imagery compared to healthy participants. Importantly, the LPP amplitudes to sad imagery in depressed participants were significantly larger than healthy controls, particularly in the middle (800-1,400 ms) and late time windows(1,400-2,000 ms). Furthermore, depressed individuals exhibited significantly higher LPP amplitudes for sad imagery compared to happy imagery, whereas healthy participants showed the opposite pattern. The present study provides evidence that depressed individuals display abnormal electrophysiological reactivity to sad imagery, which offers a new perspective for understanding the mechanisms underlying depression.

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Comorbid anxiety and depression: Opposing effects on the electrocortical processing of negative imagery in a focal fear sample

Cited by 11 publications

References 45 publications

Grounding Motivation for Behaviour Change

Grounding Motivation for Behaviour Change

Tachykinin receptor 3 in the lateral habenula alleviates pain and anxiety comorbidity in mice

Negative bias for sad imagery in depression: An ERP study

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