Community prevalence of Helicobacter pylori and dyspepsia and efficacy of triple therapy in a rural district of eastern Uganda

Lee, Yang Jae; Ssekalo, Ibrahim; Kazungu, Rauben; Blackwell, Timothy S.; Muwereza, Peter; Wu, Yuefeng; Sáenz, José B.

doi:10.1016/j.heliyon.2022.e12612

Cited by 1 publication

(1 citation statement)

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“…It should be noted, however, that in areas with low clarithromycin resistance, this therapy is still prescribed as the first-line treatment. Standard triple therapy, consisting of clarithromycin, amoxicillin, and omeprazole for 14 consecutive days, can effectively eradicate H. pylori in rural areas of eastern Uganda ( Lee et al., 2022 ). Studies documented that despite the unsatisfactory efficacy of standard triple therapy, vonoprazan triple therapy (vonoprazan, amoxicillin, and clarithromycin) achieves high eradication rates of over 90% and esomeprazole triple therapy (levofloxacin, esomeprazole, and clarithromycin) has the highest eradication rate in western countries ( Rokkas et al., 2021 ).…”

Section: Treatmentmentioning

confidence: 99%

Helicobacter pylori infection: a dynamic process from diagnosis to treatment

Sun,

Yuan,

Zhou

et al. 2023

Front. Cell. Infect. Microbiol.

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Helicobacter pylori, a gram-negative microaerophilic pathogen, causes several upper gastrointestinal diseases, such as chronic gastritis, peptic ulcer disease, and gastric cancer. For the diseases listed above, H. pylori has different pathogenic mechanisms, including colonization and virulence factor expression. It is essential to make accurate diagnoses and provide patients with effective treatment to achieve positive clinical outcomes. Detection of H. pylori can be accomplished invasively and noninvasively, with both having advantages and limitations. To enhance therapeutic outcomes, novel therapeutic regimens, as well as adjunctive therapies with probiotics and traditional Chinese medicine, have been attempted along with traditional empiric treatments, such as triple and bismuth quadruple therapies. An H. pylori infection, however, is difficult to eradicate during treatment owing to bacterial resistance, and there is no commonly available preventive vaccine. The purpose of this review is to provide an overview of our understanding of H. pylori infections and to highlight current treatment and diagnostic options.

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Section: Treatmentmentioning

confidence: 99%