In the context of the development of medical science and the transformation of medical models, higher requirements are placed before physicians with respect to comprehensive quality. Training for comprehensive quality requires strengthening of medical education. In the current training environment, it is difficult for traditional medical colleges and universities to meet this demand. Our school takes an approach that places the medical students at the center. We are conducting research on strategies and methods of the practical teaching model called "health management for relatives and friends (HMRF)." This entails managing the health of medical students' relatives and friends, establishing a network platform, and organically combining the network platform with traditional teaching. After 6 years of exploration and implementation, medical students effectively improved their autonomous learning abilities and augmented occupational qualities such as clinical thinking, doctor-patient communication, information collection, and clinical decision-making. They did this by role-playing, practicing progressive humanistic care, and transferring educational practice to clinical practice. Practical teaching of health management for relatives and friends is a new, effective, and simple training model to enhance multidimensional qualities of medical students.