Community acquired secondary bacterial peritonitis in a tertiary hospital of South India: an audit with special reference to peritoneal fluid culture

Vpm, Ramakrishnaiah; Chandramaliteeswaran, C.; Dharanipragadha, K; Sistla, Sarath Chandra; Srinivasan, Krishnamachari

doi:10.7869/tg.2012.70

Cited by 12 publications

(22 citation statements)

References 23 publications

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“…Around 18.4% of cultures were positive for Klebsiella which was comparable to the study by Ramakrishnaiah et al (18.29%) 6. Acinetobacter (0.04%) was the least cultured organism in my study, which was comparable to the study by Ramakrishnaiah et al (5.3%) 6.…”

supporting

confidence: 89%

“…Only Afridi et al, gave rectal perforations in his study, where he showed only one of his subjects having a rectal perforation 10. None of the patients in this study had a rectal perforation.The peritoneal fluid culture from 64.7% of patients were positive for cultures, of which the most common microbe isolated was E. coli (27.6 %), which was also the most common organism in the study by Ramakrishnaiah et al (34.46%) 6. Around 18.4% of cultures were positive for Klebsiella which was comparable to the study by Ramakrishnaiah et al (18.29%) 6.…”

supporting

confidence: 69%

“…None of the patients in this study had a rectal perforation.The peritoneal fluid culture from 64.7% of patients were positive for cultures, of which the most common microbe isolated was E. coli (27.6 %), which was also the most common organism in the study by Ramakrishnaiah et al (34.46%) 6. Around 18.4% of cultures were positive for Klebsiella which was comparable to the study by Ramakrishnaiah et al (18.29%) 6. Acinetobacter (0.04%) was the least cultured organism in my study, which was comparable to the study by Ramakrishnaiah et al (5.3%) 6.…”

mentioning

confidence: 85%

“…[3][4][5] In a study conducted on 352 patients in India, the Gastroduodenal perforations constituted about 51%, small bowel about 29%, appendicular perforations about 17%. 6 In a study conducted by Capoor et al on 47 cases, 32% of cases were positive for E. coli (sensitive to amikacin, cephalosporins, meropenem), 7% were positive for K. pneumonia (sensitive to cefaperazone-sulbactum, piperacillin-tazobactum), 20% were positive for C. freundii (sensitive to meropenem, piperacillintazobactum), 8% due to Enterobacter species and 8% due to S. typhi (sensitive to amikacin, cephalosporins). 7 Whereas, Ramakrishnaiah from India studied 352 cases and microbes isolated predominantly are E. coli and Klebsiella.…”

Section: Introductionmentioning

confidence: 98%

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An observational study on peritoneal fluid bacteriology in cases of gastrointestinal perforations, antibiotic management and outcome in tertiary care center

2020

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Background: Perforative peritonitis is one of the most common surgical emergencies in India. Perforation of the intestines results in the potential for bacterial contamination resulting in peritonitis.Methods: A total of 65 patients (January 2018 to Dec 2018) who presented with features of perforative peritonitis admitted to various surgical units of PES institute of medical sciences, Kuppam were included in this study. The following study was conducted to analyze bacteriology of peritoneal fluid, to assess antibiotic sensitivity pattern, to assess its impact on morbidity, mortality pattern in these cases.Results: Males outnumbered females with a ratio of 4.9:1. The most common site of perforation was pre-pyloric part of stomach (35.3%), followed by an appendix (33.8%). Peritoneal fluid was negative for culture (21.5%) in the majority of cases. Culture was positive for E. coli in 27.6% of cases and Klebsiella in 18.4% of cases, respectively. Majority of the isolated strains were sensitive to cephalosporins, quinolones, aminoglycosides. Most common postoperative complications were wound infection, respiratory complications, death.Conclusions: Studies have shown that delay in management and treatment will affect the prognosis. Empiric antimicrobial therapy is initiated and changed accordingly with peritoneal fluid culture sensitivity reports. This may reduce the incidence of postoperative complications, morbidity, and mortality.

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supporting

confidence: 89%

supporting

confidence: 69%

mentioning

confidence: 85%

Section: Introductionmentioning

confidence: 98%

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An observational study on peritoneal fluid bacteriology in cases of gastrointestinal perforations, antibiotic management and outcome in tertiary care center

2020

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“…Even in mild very common surgical emergency such as appendicitis frequently seen in young adults, in whom the outcomes are usually good, in elderly this disease is becoming more prevalent and, it is far more serious requiring an early diagnosis and treatment, and even so associated with a mortality rate of about 3%, and post-operative complication around 20% 20 .…”

Section: Discussionmentioning

confidence: 99%

Severe autogenously fecal peritonitis in ageing Wistar rats. Response to intravenous meropenem

Mascena

Melo²,

Gadelha³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the treatment outcome of severe peritonitis in rats with increasing age. METHODS:Thirty Wistar rats stratified in three groups: group I -six month-old; group II -12 month-old; and group III -18 monthold, underwent autogenously fecal peritonitis (6 ml/kg rat), and were treated with intravenous meropenem. The survival animals were followed-up for 45 days. The variables were expressed by their mean and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee. RESULTS:There was a significant increase in the mortality and morbidity in elderly rats. Of interest, even among young survival rats presenting with severe residual abscesses both in the abdomen and thorax cavities, they present an almost normal life. CONCLUSIONS:The treatment of severe autogenously fecal peritonitis with intravenous meropenem reached reasonable results in rats with six and twelve months of age, even considering residual abscesses on abdomen and thorax cavities. However, the great majority (80%) of elderly rats could not overcome the initial severe infectious challenge, proving that ageing is a very important risk factor for impairing immune response. Thus, sepsis remains a challenging situation, especially in elderly.

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Comparative phenotypic and genotypic analysis of community-acquired and hospital-acquired intra-abdominal infections among liver transplanted patients

Elmanakhly,

Safwat,

Tohamy

et al. 2024

Journal of Applied Microbiology

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Aim During liver transplantation, both hospital-acquired (HA) and community-acquired (CA) intra-abdominal infections (IAIs) are involved causing life-threatening diseases. Therefore, comparative studies of aerobic and facultative anaerobic HA-IAIs and CA-IAIs after liver transplantation surgery are necessary. Methods and Results the species of detected isolates (310) from intra-abdominal fluid were identified and classified into HA-IAIs and CA-IAIs. Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii were the most commonly detected species. The resistant phenotypes were commonly detected among the HA-IAIs; however, the virulent phenotypes were the predominant strains of CA-IAIs. Regrettably, the resistance profiles were shocking, indicating the inefficacy of monotherapy in treating these isolates. Therefore, we confirmed the use of empirical combination therapies of amikacin and meropenem for treating all IAIs (FICI≤0.5). Unfortunately, the high diversity and low clonality of all identified HA and CA-IAIs were announced with D-value in the range of 0.992 and 1. Conclusion This diversity proves that there are infinite numbers of infection sources inside and outside healthcare centers.

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Community acquired secondary bacterial peritonitis in a tertiary hospital of South India: an audit with special reference to peritoneal fluid culture

Abstract: Background: This study was conducted to elucidate the spectrum of community acquired acute bacterial peritonitis, the role of microbiological culture in its management and other

Cited by 12 publications

References 23 publications

An observational study on peritoneal fluid bacteriology in cases of gastrointestinal perforations, antibiotic management and outcome in tertiary care center

An observational study on peritoneal fluid bacteriology in cases of gastrointestinal perforations, antibiotic management and outcome in tertiary care center

Severe autogenously fecal peritonitis in ageing Wistar rats. Response to intravenous meropenem

Comparative phenotypic and genotypic analysis of community-acquired and hospital-acquired intra-abdominal infections among liver transplanted patients

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