Community-acquired Methicillin-resistantStaphylococcus aureus, Uruguay

Abstract

A novel, methicillin-resistant Staphylococcus aureus clone (Uruguay clone) with a non–multidrug-resistant phenotype caused a large outbreak, including 7 deaths, in Montevideo, Uruguay. The clone was distinct from the highly virulent community clone represented by strain MW2, although both clones carried Panton-Valentine leukocidin gene and cna gene.

Characteristics of Community-Associated Methicillin-ResistantStaphylococcus aureus(CA-MRSA) Strains Isolated from Skin and Soft-Tissue Infections in Uruguay

“…Twenty-four out of 90 (26.6%) CA-MRSA strains showed inducible macrolide-lincosamide-streptogramin B (iMLS B ) resistance by the double-disk diffusion test. This figure is similar to that obtained by Patel et al [ 34 ] and, as suggested by these authors, it might be due to the predominance of the cassette IV in Uruguayan CA-MRSA strains [ 17 ] which do not have the erm genes associated with inducible MLS B phenotype. In this regard, twenty-three CA-MRSA strains belonging to group 1 (described in what follows) showed SSC mec type-IV, whereas four group 4 strains carried SCC mec elements type-II.…”

Characteristics of Community-Associated Methicillin-ResistantStaphylococcus aureus(CA-MRSA) Strains Isolated from Skin and Soft-Tissue Infections in Uruguay

“…Twenty-four out of 90 (26.6%) CA-MRSA strains showed inducible macrolide-lincosamide-streptogramin B (iMLS B ) resistance by the double-disk diffusion test. This figure is similar to that obtained by Patel et al [ 34 ] and, as suggested by these authors, it might be due to the predominance of the cassette IV in Uruguayan CA-MRSA strains [ 17 ] which do not have the erm genes associated with inducible MLS B phenotype. In this regard, twenty-three CA-MRSA strains belonging to group 1 (described in what follows) showed SSC mec type-IV, whereas four group 4 strains carried SCC mec elements type-II.…”

Genomic epidemiology of Staphylococcus aureus isolated from bloodstream infections in South America during 2019 supports regional surveillance

“…Our findings suggest a single introduction in South America of an ST30-MRSA clone that disseminated throughout the continent, probably via travel routes, in agreement with previous reports [9, 47-49, 85, 89-91]. ST30-MRSA was first described in our region from Uruguay [92] and Brazil [93]. The paucity of genomes from earlier dates precludes us from establishing the entry point into the region with the current analysis.…”

Genomic epidemiology of S. aureus isolated from bloodstream infections in South America during 2019 supports regional surveillance

“…Our findings suggest a single introduction in South America of an MRSA-ST30 clone that disseminated throughout the continent, likely via travel routes, in agreement with previous reports [9, 47-49, 85, 89-91]. ST30-MRSA was first described in our region from Uruguay [92] and Brazil [93]. The paucity of genomes from earlier dates precludes us from establishing the entry point into the region with the current analysis.…”

Characteristics of Community-Associated Methicillin-ResistantStaphylococcus aureus(CA-MRSA) Strains Isolated from Skin and Soft-Tissue Infections in Uruguay

“…Twenty-four out of 90 (26.6%) CA-MRSA strains showed inducible macrolide-lincosamide-streptogramin B (iMLS B ) resistance by the double-disk diffusion test. This figure is similar to that obtained by Patel et al [ 34 ] and, as suggested by these authors, it might be due to the predominance of the cassette IV in Uruguayan CA-MRSA strains [ 17 ] which do not have the erm genes associated with inducible MLS B phenotype. In this regard, twenty-three CA-MRSA strains belonging to group 1 (described in what follows) showed SSC mec type-IV, whereas four group 4 strains carried SCC mec elements type-II.…”

Genomic epidemiology of Staphylococcus aureus isolated from bloodstream infections in South America during 2019 supports regional surveillance

“…Our findings suggest a single introduction in South America of an ST30-MRSA clone that disseminated throughout the continent, probably via travel routes, in agreement with previous reports [9, 47-49, 85, 89-91]. ST30-MRSA was first described in our region from Uruguay [92] and Brazil [93]. The paucity of genomes from earlier dates precludes us from establishing the entry point into the region with the current analysis.…”

Genomic epidemiology of S. aureus isolated from bloodstream infections in South America during 2019 supports regional surveillance

“…Our findings suggest a single introduction in South America of an MRSA-ST30 clone that disseminated throughout the continent, likely via travel routes, in agreement with previous reports [9, 47-49, 85, 89-91]. ST30-MRSA was first described in our region from Uruguay [92] and Brazil [93]. The paucity of genomes from earlier dates precludes us from establishing the entry point into the region with the current analysis.…”

Characteristics of Community-Associated Methicillin-ResistantStaphylococcus aureus(CA-MRSA) Strains Isolated from Skin and Soft-Tissue Infections in Uruguay

“…Twenty-four out of 90 (26.6%) CA-MRSA strains showed inducible macrolide-lincosamide-streptogramin B (iMLS B ) resistance by the double-disk diffusion test. This figure is similar to that obtained by Patel et al [ 34 ] and, as suggested by these authors, it might be due to the predominance of the cassette IV in Uruguayan CA-MRSA strains [ 17 ] which do not have the erm genes associated with inducible MLS B phenotype. In this regard, twenty-three CA-MRSA strains belonging to group 1 (described in what follows) showed SSC mec type-IV, whereas four group 4 strains carried SCC mec elements type-II.…”

Genomic epidemiology of Staphylococcus aureus isolated from bloodstream infections in South America during 2019 supports regional surveillance

“…Our findings suggest a single introduction in South America of an ST30-MRSA clone that disseminated throughout the continent, probably via travel routes, in agreement with previous reports [9, 47-49, 85, 89-91]. ST30-MRSA was first described in our region from Uruguay [92] and Brazil [93]. The paucity of genomes from earlier dates precludes us from establishing the entry point into the region with the current analysis.…”

Genomic epidemiology of S. aureus isolated from bloodstream infections in South America during 2019 supports regional surveillance

“…Our findings suggest a single introduction in South America of an MRSA-ST30 clone that disseminated throughout the continent, likely via travel routes, in agreement with previous reports [9, 47-49, 85, 89-91]. ST30-MRSA was first described in our region from Uruguay [92] and Brazil [93]. The paucity of genomes from earlier dates precludes us from establishing the entry point into the region with the current analysis.…”