2006
DOI: 10.3201/eid1106.041059
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Community-acquired Methicillin-resistantStaphylococcus aureus, Uruguay

Abstract: A novel, methicillin-resistant Staphylococcus aureus clone (Uruguay clone) with a non–multidrug-resistant phenotype caused a large outbreak, including 7 deaths, in Montevideo, Uruguay. The clone was distinct from the highly virulent community clone represented by strain MW2, although both clones carried Panton-Valentine leukocidin gene and cna gene.

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Cited by 98 publications
(87 citation statements)
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“…Interestingly, both clones (A and B) are very similar (95%) (Figure 2), nevertheless, clone A showed a reduced resistance profile as clone B, and this is because of the existence of the SCCmec IV in these isolates, this chromosomal cassette was found in relation to isolated MRSA strains in the community (CA-MRSA) (Coombs et al, 2011). Different reports of several infections caused by CA-MRSA in Latin America (Uruguay, Rio de Janeiro, Colombia, Argentina and Mexico) have been published (Alvaréz et al, 2006;Ma et al, 2005;Reyes et al, 2009;Ribeiro et al, 2005;Velazquez et al, 2011). All pattern of PFGE of the clones A, B and C showed subtypes.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, both clones (A and B) are very similar (95%) (Figure 2), nevertheless, clone A showed a reduced resistance profile as clone B, and this is because of the existence of the SCCmec IV in these isolates, this chromosomal cassette was found in relation to isolated MRSA strains in the community (CA-MRSA) (Coombs et al, 2011). Different reports of several infections caused by CA-MRSA in Latin America (Uruguay, Rio de Janeiro, Colombia, Argentina and Mexico) have been published (Alvaréz et al, 2006;Ma et al, 2005;Reyes et al, 2009;Ribeiro et al, 2005;Velazquez et al, 2011). All pattern of PFGE of the clones A, B and C showed subtypes.…”
Section: Discussionmentioning
confidence: 99%
“…A caracterização molecular demonstrou a presença do SCCmec tipo IVc e similar ao clone OSPC, confirmando os achados descritos por Ribeiro e cols, em isolados de infecções de pele nesta mesma cidade brasileira 16 . A presença do clone OSPC circulante é preocupante, visto que no país vizinho Uruguai um surto foi atribuído a este mesmo clone 12 .…”
Section: Discussionunclassified
“…5,7,8 Os abscessos e as furunculoses são as lesões mais relatadas. 2,3,5,6,8 Também são descritos celulite, pápulas ou nódulos eritematosos, placas com crostas (impetigo) ou ainda FIGURA 1: Lesões furunculoides em coxa FIGURA 2: Linha 1. amostra da paciente deste caso; Linha 2. amostra pertencente a uma variante do clone OSPC, usada para comparação; Linha 3. amostra do clone BEC (Brazilian epidemic clone), típica do MRSA hospitalar a combinação desses quadros clínicos. 6 A resistência à meticilina ocorre pela produção da PBP2a, proteína ligadora à penicilina que diminui a atividade da maioria das penicilinas.…”
Section: Discussionunclassified