Community‐acquired Klebsiella pneumoniae liver abscesses — an “emerging disease” in Australia

Anstey, James; Fazio, Timothy; Gordon, David L.; Hogg, Geoffrey G; Jenney, Adam; Maiwald, Matthias; Wilksch, Jonathan J.

doi:10.5694/j.1326-5377.2010.tb04042.x

Cited by 24 publications

(17 citation statements)

References 16 publications

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“…KLA has the characteristic radiographic findings which are different from those of Non-KLA [1, 6, 22, 30, 34, 38, 40, 41]. Up to date, the combination of systemic antibiotics and percutaneous drainage has become the treatment of choice for the management of KLA [9, 15, 16, 38, 42, 43]. …”

Section: Introductionmentioning

confidence: 99%

An Increasing Prominent Disease ofKlebsiella pneumoniaeLiver Abscess: Etiology, Diagnosis, and Treatment

Liu

Wang

Jiang

2013

Gastroenterology Research and Practice

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Background. During the past two decades, Klebsiella pneumoniae (K. pneumoniae) had surpassed Escherichia coli (E. coli) as the predominant isolate from patients with pyogenic liver abscess (PLA) in Asian countries, the United States, and Europe, and it tended to spread globally. Since the clinical symptom is atypical, the accurate and effective diagnosis and treatment of K. pneumoniae liver abscesses (KLAs) are very necessary. Methods. Here, we have comprehensively clarified the epidemiology and pathogenesis of KLA, put emphases on the clinical presentations especially the characteristic radiographic findings of KLA, and thoroughly elucidated the most effective antibiotic strategy of KLA. Results. K1 serotype is strongly associated with KLA especially in diabetic patients. Computed tomography (CT) and ultrasound (US) were two main diagnostic methods of KLA in the past. Most of KLAs have solitary, septal lobular abscesses in the right lobe of liver, and they are mainly monomicrobial. Broad-spectrum antibiotics combined with the US-guided percutaneous drainage of liver abscesses can increase their survival rates, but surgical intervention still has its irreplaceable position. Conclusion. The imaging features contribute to the early diagnosis, and the percutaneous intervention combined with an aminoglycoside plus either an extended-spectrum betalactam or a second- or third-generation cephalosporin is a timely and effective treatment of KLA.

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Section: Introductionmentioning

confidence: 99%

An Increasing Prominent Disease ofKlebsiella pneumoniaeLiver Abscess: Etiology, Diagnosis, and Treatment

Liu

Wang

Jiang

2013

Gastroenterology Research and Practice

View full text Add to dashboard Cite

show abstract

“…However, since the mid‐1990s, there has been an increase in the number of cases of KPLA reported in the United States and in the last 3 years in Europe . This study demonstrates the increasing trends of EKPE across major centres in Sydney and Melbourne, Australia that has accompanied the increase in cases of KPLA . All patients described in this Australian case series were of South‐East Asian ethnicity, as were the majority in a recent case series from the United States …”

Section: Discussionmentioning

confidence: 50%

“…12 This study demonstrates the increasing trends of EKPE across major centres in Sydney and Melbourne, Australia that has accompanied the increase in cases of KPLA. 1,3 All patients described in this Australian case series were of South-East Asian ethnicity, as were the majority in a recent case series from the United States. 4 EKPE is now the commonest cause of endogenous endophthalmitis in Asia, with up to 9% prevalence in patients with KPLA.…”

Section: Discussionmentioning

confidence: 69%

“…K . pneumoniae liver abscess (KPLA) with metastatic spread and endophthalmitis is an ‘emerging disease’ in Australia . The rising incidence of KPLA in Australia has resulted in a corresponding rise in endogenous K .…”

Section: Introductionmentioning

confidence: 99%

“…K. pneumoniae liver abscess (KPLA) with metastatic spread and endophthalmitis is an 'emerging disease' in Australia. [1][2][3] The rising incidence of KPLA in Australia has resulted in a corresponding rise in endogenous K. pneumoniae enophthalmitis (EKPE), generally noted in 3-9% of patients with KPLA 3 . Unfortunately, EKPE is associated with poor visual outcomes and a high rate of evisceration or enucleation 4 .…”

Section: Introductionmentioning

confidence: 99%

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