Communication with emblematic gestures: Shared and distinct neural correlates of expression and reception

Lindenberg, Robert; Uhlig, Marie; Scherfeld, Dag; Schlaug, Gottfried; Seitz, R.J.

doi:10.1002/hbm.21258

Cited by 41 publications

(32 citation statements)

References 61 publications

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“…One possibility is that inexpressivity may reflect a similar dysfunction in the automatic self-monitoring of expressive behavior, perhaps through common neural circuitry. In healthy populations, expressive behavior activates the ACC (Lindenberg et al, 2012)—the generator of the ERN. Moreover, ACC dysfunction has been proposed as a pathophysiological factor for negative symptoms (Bersani et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Impaired error processing in late-phase psychosis: Four-year stability and relationships with negative symptoms

Foti

Hajcak

Mohanty

et al. 2016

Schizophrenia Research

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Error processing is impaired in psychosis, and numerous event-related potential studies have found reductions in the error-related negativity (ERN) and, more recently, the error positivity (Pe). The stability of reduced ERN/Pe in psychosis, however, is unknown. In a previous cross-sectional report, reduced ERN was associated with negative symptom severity and reduced Pe with a diagnosis of schizophrenia versus other psychosis. Here, we test the stability of impaired error processing over a four-year follow-up and relationships with subdimensions of negative symptoms. The ERN and Pe were recorded from individuals with psychotic disorders twice: 79 individuals were assessed 15 years after first hospitalization, and 69 were assessed at 19 years; 59 (26 with schizophrenia, 33 with other psychotic disorders) had data at both assessments. At 19 years the Pe was blunted in schizophrenia. The ERN and Pe exhibited temporal stability over the four years (r=.59 and .60, respectively). Reduced ERN and Pe correlated with the negative symptom subdimensions of inexpressivity and avolition, respectively, and not with psychotic or disorganized symptoms. Moreover, 15-year ERN predicted an increase in inexpressivity by year 19. No evidence was found for the reverse: negative symptoms did not predict change in ERN/Pe. Similar to non-clinical samples, the ERN and Pe show impressive four-year stability in late-phase psychosis. The ERN and Pe are promising neural measures for capturing individual differences in psychotic disorders, particularly with regard to negative symptomatology. They may prove to be useful clinically for forecasting illness course and as treatment targets.

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Section: Discussionmentioning

confidence: 99%

Impaired error processing in late-phase psychosis: Four-year stability and relationships with negative symptoms

Foti

Hajcak

Mohanty

et al. 2016

Schizophrenia Research

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“…Gesture uses the motor system whereas word does not. There are studies (Andric et al, 2013;Ferri et al, 2014;Villarreal et al, 2008;Grezes, 1998;Chaminade et al, 2010;Schippers et al, 2010;Lindenberg et al, 2012;Bookheimer, 2002) which show that the motor system is involved in gesture comprehension. In contrast, words related to symbolic gestures do not seem to access the motor system Campione et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Gesture and word analysis: the same or different processes?

2015

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“…fMRI studies suggest the existence of similar domain-specific long-range connections between specialized cortical regions and the limbic system, e.g., for emotional face processing, between the fusiform gyrus, the amygdala, and the orbitofrontal cortex [23, 24]. In the motor domain, the capacity to recognize nonverbal information such as hand gestures is strongly linked to the performance of hand gestures [25], suggesting a parallel organization with direct connections between brain areas of action perception and those of action planning [26]. The cortical connections of the motor system include areas of executive control and action planning (rostral to primary motor cortex) and parietal areas of action perception (see right panel of Fig.…”

Section: Outline Of Synopsismentioning

confidence: 99%

Systems Neuroscience of Psychosis: Mapping Schizophrenia Symptoms onto Brain Systems

et al. 2017

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Schizophrenia research has been in a deadlock for many decades. Despite important advances in clinical treatment, there are still major concerns regarding long-term psychosocial reintegration and disease management, biological heterogeneity, unsatisfactory predictors of individual course and treatment strategies, and a confusing variety of controversial theories about its etiology and pathophysiological mechanisms. In the present perspective on schizophrenia research, we first discuss a methodological pitfall in contemporary schizophrenia research inherent in the attempt to link mental phenomena with the brain: we claim that the time-honored phenomenological method of defining mental symptoms should not be contaminated with the naturalistic approach of modern neuroscience. We then describe our Systems Neuroscience of Psychosis (SyNoPsis) project, which aims to overcome this intrinsic problem of psychiatric research. Considering schizophrenia primarily as a disorder of interindividual communication, we developed a neurobiologically informed semiotics of psychotic disorders, as well as an operational clinical rating scale. The novel psychopathology allows disentangling the clinical manifestations of schizophrenia into behavioral domains matching the functions of three well-described higher-order corticobasal brain systems involved in interindividual human communication, namely, the limbic, associative, and motor loops, including their corticocortical sensorimotor connections. The results of several empirical studies support the hypothesis that the proposed three-dimensional symptom structure, segregated into the affective, the language, and the motor domain, can be specifically mapped onto structural and functional abnormalities of the respective brain systems. New pathophysiological hypotheses derived from this brain system-oriented approach have helped to develop and improve novel treatment strategies with noninvasive brain stimulation and practicable clinical parameters. In clinical practice, the novel psychopathology allows confining the communication deficits of the individual patient, shifting attention from the symptoms to the intact resources. We have studied this approach and observed important advantages for therapeutic alliances, personalized treatment, and de-escalation strategies. Future studies will further conjoin clinical definitions of psychotic symptoms with brain structures and functions, and disentangle structural and functional deficit patterns within these systems to identify neurobiologically distinct subsyndromes. Neurobiologically homogeneous patient groups may provide new momentum for treatment research. Finally, lessons learned from schizophrenia research may contribute to developing a comprehensive perspective on human experience and behavior that integrates methodologically distinct, but internally consistent, insights from humanities and neuroscience.

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Communication with emblematic gestures: Shared and distinct neural correlates of expression and reception

Cited by 41 publications

References 61 publications

Impaired error processing in late-phase psychosis: Four-year stability and relationships with negative symptoms

Impaired error processing in late-phase psychosis: Four-year stability and relationships with negative symptoms

Gesture and word analysis: the same or different processes?

Systems Neuroscience of Psychosis: Mapping Schizophrenia Symptoms onto Brain Systems

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