Common regions of the human frontal lobe recruited by diverse cognitive demands

Duncan, John; Owen, Adrian M.

doi:10.1016/s0166-2236(00)01633-7

Cited by 2,200 publications

(1,757 citation statements)

References 79 publications

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“…1998) (IC24) and left‐side‐dominant lateral prefrontal regions peaking at Brodmann's area (BA) 45 (IC18). The secondary analysis detected the posterior default mode network (DMN) (IC28), primary visual cortices (IC13), and executive control network (ECN, IC21) composed of the bilateral anterior dorsolateral and medial prefrontal cortices (MPF) (Duncan and Owen 2000; Smith et al. 2009) as Imagery related.…”

Section: Resultsmentioning

confidence: 99%

Dynamic interactions of the cortical networks during thought suppression

et al. 2016

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ObjectivesThought suppression has spurred extensive research in clinical and preclinical fields, particularly with regard to the paradoxical aspects of this behavior. However, the involvement of the brain's inhibitory system in the dynamics underlying the continuous effort to suppress thoughts has yet to be clarified. This study aims to provide a unified perspective for the volitional suppression of internal events incorporating the current understanding of the brain's inhibitory system.Materials and MethodsTwenty healthy volunteers underwent functional magnetic resonance imaging while they performed thought suppression blocks alternating with visual imagery blocks. The whole dataset was decomposed by group‐independent component analysis into 30 components. After discarding noise components, the 20 valid components were subjected to further analysis of their temporal properties including task‐relatedness and between‐component residual correlation.ResultsCombining a long task period and a data‐driven approach, we observed a right‐side‐dominant, lateral frontoparietal network to be strongly suppression related. This network exhibited increased fluctuation during suppression, which is compatible with the well‐known difficulty of suppression maintenance.ConclusionsBetween‐network correlation provided further insight into the coordinated engagement of the executive control and dorsal attention networks, as well as the reciprocal activation of imagery‐related components, thus revealing neural substrates associated with the rivalry between intrusive thoughts and the suppression process.

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Section: Resultsmentioning

confidence: 99%

Dynamic interactions of the cortical networks during thought suppression

et al. 2016

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“…The involvement of some prefrontal areas in the running of very different executive functions was recently discussed by Duncan and Owen [44]. These authors demonstrated that a specific frontallobe network including the mid-dorsolateral, mid-ventrolateral and dorsal anterior cingulate is consistently associated with a broad range of cognitive tasks requiring processes as different as suppressing a prepotent but inappropriate response, the initial learning of an unfamiliar cognitive task, the storage of information in working memory and the perception of visually degraded stimuli.…”

Section: Discussionmentioning

confidence: 96%

“…However, other frontal areas (e.g., BA 6,8,44,45,47) and even parietal regions (BA 7 and BA 40) are also frequently found during the execution of executive tasks. Since these regions are involved less systematically in the different executive processes explored in this review, we can hypothesize that they have more specific functions (for example, a particular component of the shifting process).…”

Section: Discussionmentioning

confidence: 99%

Brain imaging of the central executive component of working memory

Collette

Linden

2002

Neuroscience & Biobehavioral Reviews

498

291

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“…Clinically, an isolated longer lasting cognitive manifestation has been reported especially in MLD of later juvenile or adult onset 10, 26. The frontal lobe is generally considered to be responsible for multiple cognitive domains (especially related to executive functions, e.g., working memory, episodic memory, problem solving, and perception) 27. Its impairment therefore explains the typical cognitive symptoms in juvenile MLD, which include decreasing school performance, deficiency in concentration and attention, and psychiatric symptoms 1, 10.…”

Section: Discussionmentioning

confidence: 99%

Demyelination load as predictor for disease progression in juvenile metachromatic leukodystrophy

Strölin

Krägeloh‐Mann

Kehrer

et al. 2017

Ann Clin Transl Neurol

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ObjectiveThe aim of this study was to investigate whether the extent and topography of cerebral demyelination correlates with and predicts disease progression in patients with juvenile metachromatic leukodystrophy (MLD).MethodsA total of 137 MRIs of 46 patients with juvenile MLD were analyzed. Demyelination load and brain volume were quantified using the previously developed Software “clusterize.” Clinical data were collected within the German Leukodystrophy Network and included full scale intelligence quotient (FSIQ) and gross motor function data. Voxel‐based lesion‐symptom mapping (VLSM) across the whole brain was performed to investigate the spatial relationship of cerebral demyelination with motor or cognitive function. The prognostic value of the demyelination load at disease onset was assessed to determine the severity of disease progression.ResultsThe demyelination load (corrected by the individual brain volume) correlated significantly with gross motor function (r = +0.55) and FSIQ (r = −0.55). Demyelination load at disease onset was associated with the severity of disease progression later on (P < 0.01). VLSM results associated frontal lobe demyelination with loss in FSIQ and more central region demyelination with decline of motor function. Especially progression of demyelination within the motor area was associated with severe disease progression.InterpretationWe were able to show for the first time in a large cohort of patients with juvenile MLD that the demyelination load correlates with motor and cognitive symptoms. Moreover, demyelination load at disease onset, especially the involvement of the central region, predicts severity of disease progression. Thus, demyelination load seems a functionally relevant MRI parameter.

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Common regions of the human frontal lobe recruited by diverse cognitive demands

Cited by 2,200 publications

References 79 publications

Dynamic interactions of the cortical networks during thought suppression

Dynamic interactions of the cortical networks during thought suppression

Brain imaging of the central executive component of working memory

Demyelination load as predictor for disease progression in juvenile metachromatic leukodystrophy

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