Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication

Gillies, Malcolm B; Ranakusuma, Anggi; Hoffmann, Tammy; Thorning, Sarah; McGuire, Treasure; Glasziou, Paul; Mar, Chris Del

doi:10.1503/cmaj.140848

Cited by 127 publications

(97 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 The generalizability of findings is questionable when highly selected trial participants are followed for only a short time. 5 If antibiotic-associated diarrhea is a late adverse event, short-term studies may fail to record any harm (type 2 error).…”

Section: Key Pointsmentioning

confidence: 99%

“…1 Their findings are important for prescribers and patients around the world who must weigh the benefits and harms of empiric amoxicillin therapy in situations clouded by diagnostic uncertainty. The analyses by Gillies and colleagues highlight the contentious matter of reporting adverse events, which is in need of considerable improvement.…”

mentioning

confidence: 99%

“…5 Only 18% of the trials in the study by Gillies and colleagues used a diary to record harms, 1 but such a lack of rigorous ascertainment of harm leads to "non-differential misclassification," with bias toward the null (i.e., lower estimates of risk of harm). 6 To put it simply, if you don't look properly, you won't find -a combination of poor monitoring with a lack of clear case definitions could lead to misclassification or nondetection of genuine adverse reactions.…”

mentioning

confidence: 99%

See 2 more Smart Citations

If nothing happens, is everything all right? Distinguishing genuine reassurance from a false sense of security

Loke

Mattishent

2014

CMAJ

View full text Add to dashboard Cite

Section: Key Pointsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

If nothing happens, is everything all right? Distinguishing genuine reassurance from a false sense of security

Loke

Mattishent

2014

CMAJ

View full text Add to dashboard Cite

“…4 In addition, in a systematic review, some of antibiotics' side effects such as skin rash, itching, oral candidiasis, nausea, vomiting, have been proposed. 5 Moreover, due to the complex anatomy of the furca area, the pockets depth, and the penetration of microorganisms into tissues, it is difficult to have an appropriate access to clean up. Therefore, for the reasons outlined, efforts to find adjunctive treatment have increased.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Photodynamic Therapy in the Treatment of Chronic Periodontitis: A Review of Literature

et al. 2017

View full text Add to dashboard Cite

Introduction: Chronic periodontitis is the most common periodontal disease which is related to the chronic accumulation of bacterial plaque. Since mechanical methods are not sufficient in the treatment of this disease, administration of local/systemic antibiotic is recommended following mechanical debridement. However, side effects of antibiotics such as microbial resistance and patient allergy led to development of alternative methods. One of these suggested methods is the antimicrobial photodynamic therapy (aPDT). PDT is a local noninvasive treatment modality without the side effects caused by antibiotics. The aim of this study was to review the articles related to the application of PDT with laser in the treatment of chronic periodontitis. Review of literature:In the present review of literature, the authors used key words such as chronic periodontitis, laser and photodynamic therapy, and conducted a literature search via Google Scholar and PubMed for the period of 1990 to 2015. A total of 47 articles in English were found. The articles that were not associated with the topic of research and review articles were deleted and only clinical trials were evaluated. After reviewing 23 articles' abstracts, the full texts of 16 articles were analyzed. Conclusion: Considering the safety, the lack of side effects and general advantages like more patient compliance, the PDT treatment with scaling and root planing (SRP) is recommended as an efficient adjunctive modality for the treatment of localized chronic periodontitis especially during the maintenance phase in non-surgical treatment.

show abstract

“…However, data on adverse drug reactions are not comprehensive. 5 If the infection is serious, these means the relative risk of still having the illness at 1-2 weeks was 66% with antibiotics. Nevertheless, 86% of patients given placebo had recovered by 1-2 weeks anyway.…”

Section: Harms From Antibioticsmentioning

confidence: 99%

Acute sinusitis and sore throat in primary care

Mar

2016

Aust Prescr

View full text Add to dashboard Cite

Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication

Cited by 127 publications

References 49 publications

If nothing happens, is everything all right? Distinguishing genuine reassurance from a false sense of security

If nothing happens, is everything all right? Distinguishing genuine reassurance from a false sense of security

The Effect of Photodynamic Therapy in the Treatment of Chronic Periodontitis: A Review of Literature

Acute sinusitis and sore throat in primary care

Contact Info

Product

Resources

About