Common Features of Patients With Autoimmune Atrophic Gastritis

Miceli, Emanuela; Lenti, Marco Vincenzo; Padula, Donatella; Luinetti, Ombretta; Vattiato, C.; Monti, Claudio; M, Di Stefano; Corazza, Gino Roberto

doi:10.1016/j.cgh.2012.02.018

Cited by 92 publications

(88 citation statements)

References 18 publications

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“…Autoimmune gastritis is characterized by a chronic inflammatory infiltration in the gastric corpus mucosa as a result of autoimmune destruction mediated by APCAs (16), which is silent initially and becomes clinically manifest by the development of pernicious anemia (11) or is incidentally diagnosed due to other disorders (18). Most previous studies investigating the relation of CAG with autoimmune response and H. pylori infection were based on clinically selected populations and may therefore not have included the majority of asymptomatic CAG cases.…”

Section: Discussionmentioning

confidence: 99%

“…However, pertinent evidence reported to date was primarily based on relatively small studies from the clinical setting. As a substantial proportion of CAGs are asymptomatic (17), and autoimmune gastritis is often an incidental diagnosis (18), large population-based studies are needed for a more comprehensive epidemiologic assessment. We therefore assessed the association of CAG with APCA positivity in a large population-based study, paying particular attention to the possible role of H. pylori infection.…”

Section: Introductionmentioning

confidence: 99%

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Gastric Parietal Cell Antibodies, Helicobacter Pylori Infection, and Chronic Atrophic Gastritis: Evidence from a Large Population-based Study in Germany

Zhang

Weck

Schöttker

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

103

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Background: Striking similarities between autoimmune gastritis and Helicobacter Pylori (H. pylori)-associated gastritis have suggested a potential link between these two pathologic conditions in the progression of chronic atrophic gastritis (CAG); however, evidence has remained conflicting.Methods: Serum pepsinogen I and II, and antibodies against H. pylori in general, the cytotoxin-associated gene A protein (CagA) and parietal cells were measured by ELISA in 9,684 subjects aged 50 to 74 years. Antigastric parietal cell antibody (APCA) prevalence was examined in the overall population and according to sex, age, and H. pylori serostatus. The association between APCA prevalence and CAG was assessed by logistic regression, overall and according to H. pylori status, controlling for potential confounding factors.Results: Overall APCA prevalence was 19.5%. APCA prevalence was strongly associated with CAG, and the association was increasing with increasing severity of CAG. Furthermore, the association between APCA and CAG was even stronger among H. pylori-negative subjects [odds ratio (OR) ¼ 11.3; 95% confidence interval (CI): 7.5-17.1)] than among H. pylori-positive subjects (OR ¼ 2.6; 95% CI: 2.1-3.3).Conclusions: APCA may play a role on the development of gastric atrophy, irrespective of H. pylori infection. Impact: Assessment of APCA might be a useful complement to established markers (such as pepsinogens and H. pylori antibodies) in screening for CAG. Cancer Epidemiol Biomarkers Prev; 22(5); 821-6. Ó2013 AACR.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gastric Parietal Cell Antibodies, Helicobacter Pylori Infection, and Chronic Atrophic Gastritis: Evidence from a Large Population-based Study in Germany

Zhang

Weck

Schöttker

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

103

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“…Ombretta Repetto, 1 Stefania Zanussi, 2 Mariateresa Casarotto, 2 Vincenzo Canzonieri, 3 Paolo De Paoli, 1 Renato Cannizzaro, 4 and Valli De Re 1 1 Facility of Bio-Proteomics, 2 Microbiology-Immunology and Virology, 3 Pathology Unit, and 4 Gastroenterology Unit, Centro di Riferimento Oncologico (CRO), Aviano National Cancer Institute, Aviano, Italy…”

Section: O L M E D 2 0 : 5 7 -7 1 2 0 1 4 | R E P E T T O E T a Lmentioning

confidence: 99%

“…AG is characterized by immune-mediated chronic inflammation, mucosal gland atrophy, with increased serum autoantibodies to gastric parietal cells and/or intrinsic factors, hypochlorhydria, vitamin B12 deficiency and, in some cases, neurological symptoms and diffuse metaplasia. In the late stages, patients show a higher risk for developing both neuroendocrine (carcinoid) and glandular (adenocarcinoma) tumors (1)(2)(3)(4). In the presence of atrophy, AG is called atrophic AG (AAG).…”

Section: Introductionmentioning

confidence: 99%

Differential Proteomics of Helicobacter pylori Associated with Autoimmune Atrophic Gastritis

Repetto

Zanussi

Casarotto

et al. 2013

Mol Med

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“…Although the additional measurement of CgA and APCA levels did not improve the sensitivity, the combination of gastrin levels >89.5 ng/ml and low B 12 levels (<210 pg/ml) increased the specificity in up to 96.1%. Autoimmune atrophic gastritis often seen in patients with AITD [15] is characterized by immune-mediated chronic inflammation of the gastric mucosa and may lead to hypoachlorhydria and vitamin B 12 deficiency [16]. In such patients, the additional finding of normal vitamin B 12 levels can help identify patients without ECLH.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Gastrin Levels for the Diagnosis of Gastric Enterochromaffin-Like Cell Hyperplasia in Patients with Hashimoto's Thyroiditis

et al. 2014

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Aim: Gastrin and chromogranin A (CgA) levels have been tested for the diagnosis of enterochromaffin-like cell hyperplasia (ECLH) in patients with type 1 diabetes and autoimmune atrophic gastritis but not for patients with Hashimoto's thyroiditis (HT). The aim of the study was to develop receiver operating characteristic (ROC) curves for gastrin and CgA levels and other clinical and biochemical parameters, as means for pretest probability of gastric ECLH in patients with HT. Methods: A total of 115 patients with HT were prospectively studied for a median period of 4 (2-7) years. Gastrin, CgA, vitamin B₁₂, anti-parietal cell antibodies, free thyroxine, thyrotropin, and neuron-specific enolase levels were measured. Their predictive values were calculated according to the histological findings for ECLH diagnosis from esophagogastroduodenoscopy-obtained biopsies. Results: Thirteen patients (11.3%) had ECLH. The areas under the curve for gastrin and CgA level were 0.898 (p < 0.001) and 0.853 (p < 0.001), respectively. The product sensitivity × specificity was 0.803 and 0.653 for gastrin and CgA levels >89.5 and >89.1 ng/ml, respectively. Two and 4 patients with ECLH had normal gastrin and CgA levels, respectively. The most specific combined parameters predicting ECLH were gastrin >89.5 ng/ml with concomitant low B₁₂ levels (96.1% specificity). Conclusion: Gastrin levels have high diagnostic accuracy for ECLH identification in patients with HT, and are highly specific when combined with low B₁₂ levels. However, they should be interpreted with caution, as somepatients may harbor gastric ECLH even if gastrin levels are not increased, necessitating further follow-up.

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Common Features of Patients With Autoimmune Atrophic Gastritis

Cited by 92 publications

References 18 publications

Gastric Parietal Cell Antibodies, Helicobacter Pylori Infection, and Chronic Atrophic Gastritis: Evidence from a Large Population-based Study in Germany

Gastric Parietal Cell Antibodies, Helicobacter Pylori Infection, and Chronic Atrophic Gastritis: Evidence from a Large Population-based Study in Germany

Differential Proteomics of Helicobacter pylori Associated with Autoimmune Atrophic Gastritis

Predictive Value of Gastrin Levels for the Diagnosis of Gastric Enterochromaffin-Like Cell Hyperplasia in Patients with Hashimoto's Thyroiditis

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