Gastric Parietal Cell Antibodies, <i>Helicobacter Pylori</i> Infection, and Chronic Atrophic Gastritis: Evidence from a Large Population-based Study in Germany

Zhang, Yan; Weck, Melanie N.; Schöttker, Ben; Rothenbacher, Dietrich; Brenner, Hermann

doi:10.1158/1055-9965.epi-12-1343

Cited by 106 publications

(52 citation statements)

References 37 publications

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“…These antibodies, which target parietal cells of the stomach, have been recently associated with a substantially higher risk of atrophic gastritis (154). The association was much stronger in H. pylori negative (OR = 11.3) than in H. pylori positive (OR = 2.6) individuals.…”

Section: Screeningmentioning

confidence: 99%

Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention

Karimi

Islami

Anandasabapathy

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

1,460

1,210

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Less than a century ago, gastric cancer (GC) was the most common cancer in the United States and perhaps throughout the world. Despite its worldwide decline in incidence over the past century, GC remains a major killer across the globe. This article reviews the epidemiology, screening, and prevention of gastric cancer. We first discuss the descriptive epidemiology of GC, including its incidence, survival, and mortality, including trends over time. Next, we characterize the risk factors for gastric cancer, both environmental and genetic. Serological markers and histological precursor lesions of GC and early detection of GC of using these markers is reviewed. Finally, we discuss prevention strategies and provide suggestions for further research.

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Section: Screeningmentioning

confidence: 99%

Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention

Karimi

Islami

Anandasabapathy

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

1,460

1,210

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“…Trefoil factor 3, a small and stable molecule secreted by the gastrointestinal tract, has been shown to be a better biomarker for both atrophy and gastric cancer than pepsinogens [80,81]. In addition, anti-gastric parietal cell antibodies have been considered as independent biomarkers for gastric atrophy [82]. The combination detection of these biomarkers may increase the sensitivity and specify of prediction of gastric cancer development in high-risk populations.…”

Section: Prevention Strategies For Gastric Cancermentioning

confidence: 99%

Etiology and Prevention of Gastric Cancer

Cheng

Lin

2016

Gastrointest Tumors

129

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Background: Gastric cancer is a heterogeneous malignant disease associated with environmental and genetic predisposing factors. While gastric cancer incidence and mortality fell greatly globally over the past decades, it remains the fourth cause of cancer-related death worldwide. Thus, prevention of gastric cancer is still a major strategy for improvement of gastric cancer prognosis. Summary:Helicobacter pylori infection has been demonstrated to be a major risk factor for the development of gastric cancer. Unhealthy diet and lifestyle, including high-salt food, smoking and drinking, are able to induce genotypic and phenotypic transformation of gastric epithelial cells. Gene mutations (such as E-cadherin) in stomach epithelial cells are major genetic causes for gastric cancer. The eradication of H. pylori has been demonstrated to be an effective approach for primary prevention of gastric cancer. Increased intake of a diet rich in vegetables and fresh fruits as well as smoking cessation have been shown to reduce the incidence of gastric cancer. The secondary prevention strategy is to screen premalignant gastric lesions by endoscopy. Biomarker tests are also reliable methods to identify gastric precancerous lesions. Endoscopy screening is still the gold standard for diagnosis of gastric cancer. Key Message:H. pylori infection, a diet rich in salted and/or smoked food and red meat, as well as gene mutations are major risk factors for the development of gastric cancer. Practical Implications: The eradication of H. pylori is a major primary preventive strategy of gastric cancer. A healthy lifestyle, including increased intake of a diet rich in fruit and vegetables, reduced intake of salted and smoked food and red meat, a reduction of alcohol intake as well as smoking cessation will be effective approaches for the prevention of gastric cancer.

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“…The H. pylori infection rate in China has dropped from 60.5% in 2000 to a current rate of 52.2% . In addition to H. pylori infection, autoimmune gastritis can cause gastric mucosal atrophy as well, and approximately 20% of those aged 50–74 years are positive for parietal cell antibody …”

Section: Epidemiologymentioning

confidence: 99%