Common Disconnections in Glioma Surgery: An Anatomic Description&#x0D;

Glenn, Chad A.; Conner, Andrew K.; Rahimi, Meherzad; Briggs, Robert G.; Baker, Cordell M; Sughrue, Michael E.

doi:10.7759/cureus.1778

Cited by 8 publications

(10 citation statements)

References 22 publications

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“…Glioma is one of the most common human malignant tumour, moreover, it acts as the aggressive tumour and primary brain tumour in the central nervous system . Glioma, accounting for 70% of brain tumours, causes thousands of cancer‐related death worldwide.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA CASC9/miR‐519d/STAT3 positive feedback loop facilitate the glioma tumourigenesis

Liu

Yang

et al. 2018

J Cellular Molecular Medi

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Emerging evidence have illustrated the vital roles of long noncoding RNAs (lncRNAs) in glioma. Nevertheless, the majority of their roles and mechanisms in gliomagenesis are still largely unclear. In this study, we investigate the roles of lncRNA CASC9 on glioma tumourigenesis and authenticate its potential mechanisms. Results manifested that CASC9 was highly expressed in glioma specimens and cells, moreover, the ectopic overexpression was correlated with glioma patients’ clinic. Functional studies found that siRNA‐mediated CASC9 silencing inhibited the proliferative ability, invasion in vitro, and impaired the tumour growth in vivo. Mechanical studies revealed that miR‐519d both targeted the 3′‐UTR of CASC9 and STAT3 mRNA, which was identified by luciferase reporter assay and RNA immunoprecipitation (RIP). Moreover, chromatin immunoprecipitation (ChIP) and luciferase reporter assay revealed that STAT3, an oncogenic transcription factor, could bind with the promoter of CASC9 and activate its transcriptional level. In conclusion, our results concluded that CASC9 promotes STAT3 expression via sponging miR‐519d, in return, STAT3 activate CASC9 transcription, forming a positive feedback loop of CASC9/miR‐519d/STAT3. The novel finding provides a potential therapeutic target for glioma.

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Section: Introductionmentioning

confidence: 99%

Long noncoding RNA CASC9/miR‐519d/STAT3 positive feedback loop facilitate the glioma tumourigenesis

Liu

Yang

et al. 2018

J Cellular Molecular Medi

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“…23, 87 Glenn et al defined common disconnection syndromes in glioma surgery that offer yet another strategy to maximize tumor resection without exacerbating existing symptoms. 86,247 A similar approach is described by Jiménez-Peña et al for essential tracts in language and reading. 278 There have been reports on potential biomarkers for outcome prediction.…”

Section: Tractography In Neurosurgical Planningmentioning

confidence: 97%

Tractography in Neurosurgery: A Systematic Review of Current Applications

Wende

Hoffmann

Meixensberger

2020

J Neurol Surg A Cent Eur Neurosurg

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The ability to visualize the brain's fiber connections noninvasively in vivo is relatively young compared with other possibilities of functional magnetic resonance imaging. Although many studies showed tractography to be of promising value for neurosurgical care, the implications remain inconclusive. An overview of current applications is presented in this systematic review. A search was conducted for ((“tractography” or “fiber tracking” or “fibre tracking”) and “neurosurgery”) that produced 751 results. We identified 260 relevant articles and added 20 more from other sources. Most publications concerned surgical planning for resection of tumors (n = 193) and vascular lesions (n = 15). Preoperative use of transcranial magnetic stimulation was discussed in 22 of these articles. Tractography in skull base surgery presents a special challenge (n = 29). Fewer publications evaluated traumatic brain injury (TBI) (n = 25) and spontaneous intracranial bleeding (n = 22). Twenty-three articles focused on tractography in pediatric neurosurgery. Most authors found tractography to be a valuable addition in neurosurgical care. The accuracy of the technique has increased over time. There are articles suggesting that tractography improves patient outcome after tumor resection. However, no reliable biomarkers have yet been described. The better rehabilitation potential after TBI and spontaneous intracranial bleeding compared with brain tumors offers an insight into the process of neurorehabilitation. Tractography and diffusion measurements in some studies showed a correlation with patient outcome that might help uncover the neuroanatomical principles of rehabilitation itself. Alternative corticofugal and cortico-cortical networks have been implicated in motor recovery after ischemic stroke, suggesting more complex mechanisms in neurorehabilitation that go beyond current models. Hence tractography may potentially be able to predict clinical deficits and rehabilitation potential, as well as finding possible explanations for neurologic disorders in retrospect. However, large variations of the results indicate a lack of data to establish robust diagnostical concepts at this point. Therefore, in vivo tractography should still be interpreted with caution and by experienced surgeons.

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“…A central goal in neurosurgery is to have a firm set of guidelines on brain regions to avoid resecting to prevent neurological decline (Becker et al, 2020;Glenn et al, 2017;Panesar et al, 2019). While some structure-function relationships are firmly established, for example that damage to the corticospinal tract causes long-term contralateral motor deficits, in most cases it is difficult to avoid postoperative cognitive deficits.…”

Section: Clinical Advantages Of Re-parcellating Schemementioning

confidence: 99%

“…The use of big data for parcellating the cerebral cortex has become a defining hallmark of modern brain mapping. Specifically, boundary mapping and clustering/factorization methods to parcellate the healthy human brain have become a gold-standard in the field (Bijsterbosch et al, 2020;Glasser et al, 2016;Glenn et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Connectivity‐based parcellation of normal and anatomically distorted human cerebral cortex

Doyen

Nicholas

Poologaindran

et al. 2021

Human Brain Mapping

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For over a century, neuroscientists have been working toward parcellating the human cortex into distinct neurobiological regions. Modern technologies offer many parcellation methods for healthy cortices acquired through magnetic resonance imaging. However, these methods are suboptimal for personalized neurosurgical application given that pathology and resection distort the cerebrum. We sought to overcome this problem by developing a novel connectivity-based parcellation approach that can be applied at the single-subject level. Utilizing normative diffusion data, we first developed a machine-learning (ML) classifier to learn the typical structural connectivity patterns of healthy subjects. Specifically, the Glasser HCP atlas was utilized as a prior to calculate the streamline connectivity between each voxel and each parcel of the atlas. Using the resultant feature vector, we determined the parcel identity of each voxel in neurosurgical patients (n = 40) and thereby iteratively adjusted the prior. This approach enabled us to create patient-specific maps independent of brain shape and pathological distortion. The supervised ML classifier reparcellated an average of 2.65% of cortical voxels across a healthy dataset (n = 178) and an average of 5.5% in neurosurgical patients. Our patient dataset consisted of subjects with supratentorial infiltrating gliomas operated on by the senior author who then assessed the validity and practical utility of the re-parcellated diffusion data. We demonstrate a rapid and effective ML parcellation approach to parcellation of the human cortex during anatomical distortion. Our approach overcomes limitations of indiscriminately applying atlas-based registration from healthy subjects by employing a voxel-wise connectivity approach based on individual data.

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Common Disconnections in Glioma Surgery: An Anatomic Description

Cited by 8 publications

References 22 publications

Long noncoding RNA CASC9/miR‐519d/STAT3 positive feedback loop facilitate the glioma tumourigenesis

Long noncoding RNA CASC9/miR‐519d/STAT3 positive feedback loop facilitate the glioma tumourigenesis

Tractography in Neurosurgery: A Systematic Review of Current Applications

Connectivity‐based parcellation of normal and anatomically distorted human cerebral cortex

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