Common classification schemes for PCB congeners and the gene expression of CYP17, CYP19, ESR1 and ESR2

Warner, J.; Osuch, Janet; Karmaus, Wilfried; Landgraf, Jeff; Taffe, Bonita; O’Keefe, Michael; Mikucki, Dorota; Haan, Pam

doi:10.1016/j.scitotenv.2011.10.044

Cited by 48 publications

(35 citation statements)

References 45 publications

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“…Interestingly, all these in vitro results point in the same direction as findings by Warner et al (2012) who found a positive association between blood serum PCB levels and an upregulation of enzymes involved in estrogen synthesis in daughters of the Michigan Fisheaters' Cohort.…”

Section: Comparison Of Results With Earlier Findingssupporting

confidence: 79%

Endocrine activity of persistent organic pollutants accumulated in human silicone implants — Dosing assays by partitioning from silicone

Gilbert

Mayer

Pedersen

et al. 2015

Environment International

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Section: Comparison Of Results With Earlier Findingssupporting

confidence: 79%

Endocrine activity of persistent organic pollutants accumulated in human silicone implants — Dosing assays by partitioning from silicone

Gilbert

Mayer

Pedersen

et al. 2015

Environment International

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“…It is also suspected that AhR interacts with the estrogen receptors (ER) α and β [16,98,101]. PCB exposure is related to increased expression of ESR2, a gene encoding ER β, and up-regulation of CYP19, a gene coding for aromatase [102]. Aromatase belongs to the cytochrome P450 superfamily and is crucial for the aromatization of androgens into estrogens.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to these findings, Sarachana and Hu [112] found evidence for the involvement of AR and ERα in RORA gene expression. Hence, RORA provides a plausible target gene for EDCs, such as PCDD/Fs and PCBs, because these compounds seem capable of interacting with AR and, via AhR, with ER and have also been associated with an up-regulation of CYP19A1 [102]. …”

Section: Discussionmentioning

confidence: 99%

Influence of Low-Level Prenatal Exposure to PCDD/Fs and PCBs on Empathizing, Systemizing and Autistic Traits: Results from the Duisburg Birth Cohort Study

et al. 2015

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BackgroundPolychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) are assumed to act as endocrine disruptor chemicals. Prenatal exposure to these pollutants might influence fetal steroid hormone levels, which are thought to be related to sex-typical development and autistic traits.ObjectivesWe examined associations of prenatal levels of PCDD/Fs and PCBs with autism traits and sex-typical behaviour in childhood.MethodsWe measured levels of PCDD/Fs and PCBs in maternal blood samples during pregnancy using gas chromatography/high-resolution mass spectrometry. Sex-typical behaviour was assessed at 9 years of age (n = 96) and autistic traits at 10 years of age using the Social Responsiveness Scale (SRS; n = 100). Multiple regression analyses were conducted to estimate the associations between prenatal exposure and outcome variables.ResultsBlood concentrations (WHO2005-TEq) of ƩPCDD/Fs ranged from 2.93–46.45 pg/g lipid base (median = 12.91 pg/g lipid base) and concentrations of ƩPCBs were in the range of 1.24–25.47 pg/g lipid base (median = 6.85 pg/g lipid base) which is within the range of German background exposure. We found significant negative associations between PCDD/F levels in maternal blood and SRS scores in the whole group (β = -6.66, p < .05), in girls (β = -10.98, p < .05) and, in one SRS subscale, in boys (β = -6.86, p < .05). For PCB levels, associations with one SRS subscale were significant for the whole study group as were associations with two subscales in girls. We did not find significant associations between PCDD/F or PCB levels and sex-typical behaviour for either sex.ConclusionsIn an earlier part of this study, prenatal exposure to PCDD/Fs and PCBs was found to be associated with lower testosterone levels, therefore, our findings are consistent with the idea that autism spectrum conditions are related to fetal androgen levels. Several possible mechanisms, through which PCDD/Fs and PCBs might influence autistic behaviour, are discussed.

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“…Given that PCBs accumulate in breast adipose tissue and reduce global DNA methylation, they may have a role in the sustained and increased levels of intratumoral estrogens. Indeed, there are numerous studies demonstrating that PCBs alter the expression of aromatase and other sex steroid metabolism enzymes in human (Drenth et al 1998, Wojtowicz et al 2005, Li 2007, Dhooge et al 2011, Karmaus et al 2011, Warner et al 2012) and animal models (Hany et al 1999, Kaya et al 2002). In one instance, methylsulfonyl PCB metabolites (MeSO2-PCBs) were found to inhibit aromatase expression and activity in breast adipose fibroblasts (Heneweer et al 2005).…”

Section: Polychlorinated Biphenylsmentioning

confidence: 99%

Endocrine disruption of the epigenome: a breast cancer link

Knower¹,

To²,

Leung³

et al. 2014

Endocrine-Related Cancer

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The heritable component of breast cancer accounts for only a small proportion of total incidences. Environmental and lifestyle factors are therefore considered to among the major influencing components increasing breast cancer risk. Endocrine-disrupting chemicals (EDCs) are ubiquitous in the environment. The estrogenic property of EDCs has thus shown many associations between ongoing exposures and the development of endocrine-related diseases, including breast cancer. The environment consists of a heterogenous population of EDCs and despite many identified modes of action, including that of altering the epigenome, drawing definitive correlations regarding breast cancer has been a point of much discussion. In this review, we describe in detail well-characterized EDCs and their actions in the environment, their ability to disrupt mammary gland formation in animal and human experimental models and their associations with exposure and breast cancer risk. We also highlight the susceptibility of early-life exposure to each EDC to mediate epigenetic alterations, and where possible describe how these epigenome changes influence breast cancer risk.

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Common classification schemes for PCB congeners and the gene expression of CYP17, CYP19, ESR1 and ESR2

Cited by 48 publications

References 45 publications

Endocrine activity of persistent organic pollutants accumulated in human silicone implants — Dosing assays by partitioning from silicone

Endocrine activity of persistent organic pollutants accumulated in human silicone implants — Dosing assays by partitioning from silicone

Influence of Low-Level Prenatal Exposure to PCDD/Fs and PCBs on Empathizing, Systemizing and Autistic Traits: Results from the Duisburg Birth Cohort Study

Endocrine disruption of the epigenome: a breast cancer link

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