Comments on the paper "High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients. C.G. Coimbraand V.B.C. Junqueira. Brazilian Journal of Medical and Biological Research, 36: 1409-1417, 2003"

Ferraz, Henrique B.; Quagliato, Elizabeth; Rieder, Carlos Roberto de Mello; Silva, D.J.; Teive, Hélio Afonso Ghizoni; Barbosa, Egberto Reis; Cardoso, Francisco; Limongi, João Carlos Papaterra; Bezerra, José Marcelo Ferreira; Andrade, Luiz Augusto Franco de; Allam, Nasser; Prado, Roberto; Tomáš, Vladimír

doi:10.1590/s0100-879x2004000900002

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…Despite these characteristics, some studies found that riboflavin is not associated with the risk of PD (Abbott et al, 2003; Murakami et al, 2010b), whereas another study observed improved motor skills in PD patients with daily supplementation of riboflavin for 6 months and elimination of red meat (Coimbra and Junqueira, 2003). However, several limitations of this study including omission of a placebo control group and the investigators not being blinded have lead others to question these findings (Ferraz et al, 2004). Another important consideration is that lower protein consumption may affect the absorption of levodopa (Pare et al, 1992; Crevoisier et al, 2003).…”

Section: Nutrients That May Be Associated With a Decreased Risk Or Prmentioning

confidence: 97%

“…Another important consideration is that lower protein consumption may affect the absorption of levodopa (Pare et al, 1992; Crevoisier et al, 2003). Therefore, the apparent benefit in motor skills could have resulted from a better absorption of levodopa as opposed to riboflavin supplementation (Ferraz et al, 2004). In addition, intake of other related B vitamins including folate, vitamin B6 and B12 are not associated with a risk of PD (Chen et al, 2004).…”

Section: Nutrients That May Be Associated With a Decreased Risk Or Prmentioning

confidence: 99%

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The emerging role of nutrition in Parkinson's disease

Seidl

Santiago

Bilyk

et al. 2014

Front. Aging Neurosci.

175

128

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Parkinson's disease (PD) is the second most prevalent neurodegenerative disease in ageing individuals. It is now clear that genetic susceptibility and environmental factors play a role in disease etiology and progression. Because environmental factors are involved with the majority of the cases of PD, it is important to understand the role nutrition plays in both neuroprotection and neurodegeneration. Recent epidemiological studies have revealed the promise of some nutrients in reducing the risk of PD. In contrast, other nutrients may be involved with the etiology of neurodegeneration or exacerbate disease progression. This review summarizes the studies that have addressed these issues and describes in detail the nutrients and their putative mechanisms of action in PD.

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Section: Nutrients That May Be Associated With a Decreased Risk Or Prmentioning

confidence: 97%

Section: Nutrients That May Be Associated With a Decreased Risk Or Prmentioning

confidence: 99%

The emerging role of nutrition in Parkinson's disease

Seidl

Santiago

Bilyk

et al. 2014

Front. Aging Neurosci.

175

128

View full text Add to dashboard Cite

show abstract

“…Despite these characteristics, some studies found that riboflavin is not associated with the risk of PD (Abbott et al, 2003;Murakami et al, 2010b), whereas another study observed improved motor skills in PD patients with daily supplementation of riboflavin for 6 months and elimination of red meat (Coimbra and Junqueira, 2003). However, several limitations of this study including omission of a placebo control group and the investigators not being blinded have lead others to question these findings (Ferraz et al, 2004). Another important consideration is that lower protein consumption may affect the absorption of levodopa (Pare et al, 1992;Crevoisier et al, 2003).…”

Section: Nutrients That May Be Associated With a Decreased Risk Or Prmentioning

confidence: 84%

“…Another important consideration is that lower protein consumption may affect the absorption of levodopa (Pare et al, 1992;Crevoisier et al, 2003). Therefore, the apparent benefit in motor skills could have resulted from a better absorption of levodopa as opposed to riboflavin supplementation (Ferraz et al, 2004). In addition, intake of other related B vitamins including folate, vitamin B6 and B12 are not associated with a risk of PD (Chen et al, 2004).…”

Section: Nutrients That May Be Associated With a Decreased Risk Or Prmentioning

confidence: 99%

Splice Variant Biomarkers for Parkinson's Disease

Potashkin¹

2014

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATEMay PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) AND ADDRESS(ES) PERFORMING ORGANIZATION REPORT NUMBERRosalind Franklin U. Medicine & Science 3333 Green Bay Rd. North Chicago, IL 60064-3037 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTRecently we identified splice variants in whole blood than can distinguish early stage Parkinson's disease (PD) patients from healthy and neurodegenerative controls. The proposed studies will test the hypothesis that the biomarkers will be useful for identifying individuals at risk for PD and for identifying signaling pathways that are disrupted in PD. We are testing the expression of the biomarkers in RNA prepared from whole blood of hyposmic participants in the Parkinson's Associated Risk Study (PARS) (Technical Objective 1.0). In order to establish a model for testing the function of the biomarkers, we are determining whether their expression is altered in human olfactory neurosphere-derived (hONS) cells derived from idiopathic PD patients and healthy controls (Technical Objective 2.0). To determine the signaling pathways affected in PD and identify additional biomarkers, we are using network analysis (Technical Objective 3.0). During year 1, RNA and cDNA was prepared from PARS samples from Year 0 (baseline) and Year 2. Quantitative polymerase chain reactions were initiated for two of the biomarkers (APP, HNF4α). Expression of the biomarkers was tested in hONS. We also developed network approaches to reveal the common molecular pathways involved with PD and type 2 diabetes (T2DM). Using these networks, we identified APP, HNF4A and SOD2 mRNAs as blood biomarkers predictive of early stage PD. In addition, we determined that HNF4A mRNA may be a progression marker in blood for PD. SUBJECT TERMSParkinson's disease, biomarkers, neurodegeneration, network and pathway analysis 12-15Santiago 16-23Sei...

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Riboflavin usage in pediatric migraine

Yamanaka

2023

Vitamins and Minerals in Neurological Disorders

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Comments on the paper "High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients. C.G. Coimbraand V.B.C. Junqueira. Brazilian Journal of Medical and Biological Research, 36: 1409-1417, 2003"

Cited by 4 publications

References 10 publications

The emerging role of nutrition in Parkinson's disease

The emerging role of nutrition in Parkinson's disease

Splice Variant Biomarkers for Parkinson's Disease

Riboflavin usage in pediatric migraine

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