The emerging role of nutrition in Parkinson's disease

Seidl, Stacey E.; Santiago, José A.; Bilyk, Hope McClusky; Potashkin, Judith A.

doi:10.3389/fnagi.2014.00036

Cited by 174 publications

(129 citation statements)

References 246 publications

(295 reference statements)

Supporting

Mentioning

126

Contrasting

Order By: Relevance

“…In a network-based study similar to this, APP was identified as a negative regulator of insulin abundance in plasma of mice and a potential link between Alzheimer's disease and type 2 diabetes was suggested [36]. This finding is interesting in light of the recent studies that suggest the involvement of insulin resistance and diabetes in Parkinson's disease [1,23,37]. A potential link between APP processing, insulin regulation and neurodegeneration warrants further investigation.…”

Section: Discussionsupporting

confidence: 60%

“…5. Published a paper entitled "The Emerging Role of Nutrition in Parkinson's Disease" to Frontiers in Aging Neuroscience (Seidl et al, 2014). Submitted 5-Nov-2013.…”

Section: Reportable Outcomesmentioning

confidence: 99%

“…This information may now be used to identify potential therapeutic targets of PD. And last, but not least, identification of nutrients that are potentially neuroprotective for PD provides clinicians with information that may be used in counseling their patients (Seidl et al, 2014). In this regard, this study will be featured on the website Value-Based Care in Neurology.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Splice Variant Biomarkers for Parkinson's Disease

Potashkin¹

2014

View full text Add to dashboard Cite

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATEMay PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) AND ADDRESS(ES) PERFORMING ORGANIZATION REPORT NUMBERRosalind Franklin U. Medicine & Science 3333 Green Bay Rd. North Chicago, IL 60064-3037 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTRecently we identified splice variants in whole blood than can distinguish early stage Parkinson's disease (PD) patients from healthy and neurodegenerative controls. The proposed studies will test the hypothesis that the biomarkers will be useful for identifying individuals at risk for PD and for identifying signaling pathways that are disrupted in PD. We are testing the expression of the biomarkers in RNA prepared from whole blood of hyposmic participants in the Parkinson's Associated Risk Study (PARS) (Technical Objective 1.0). In order to establish a model for testing the function of the biomarkers, we are determining whether their expression is altered in human olfactory neurosphere-derived (hONS) cells derived from idiopathic PD patients and healthy controls (Technical Objective 2.0). To determine the signaling pathways affected in PD and identify additional biomarkers, we are using network analysis (Technical Objective 3.0). During year 1, RNA and cDNA was prepared from PARS samples from Year 0 (baseline) and Year 2. Quantitative polymerase chain reactions were initiated for two of the biomarkers (APP, HNF4α). Expression of the biomarkers was tested in hONS. We also developed network approaches to reveal the common molecular pathways involved with PD and type 2 diabetes (T2DM). Using these networks, we identified APP, HNF4A and SOD2 mRNAs as blood biomarkers predictive of early stage PD. In addition, we determined that HNF4A mRNA may be a progression marker in blood for PD. SUBJECT TERMSParkinson's disease, biomarkers, neurodegeneration, network and pathway analysis 12-15Santiago 16-23Sei...

show abstract

Section: Discussionsupporting

confidence: 60%

“…5. Published a paper entitled "The Emerging Role of Nutrition in Parkinson's Disease" to Frontiers in Aging Neuroscience (Seidl et al, 2014). Submitted 5-Nov-2013.…”

Section: Reportable Outcomesmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Splice Variant Biomarkers for Parkinson's Disease

Potashkin¹

2014

View full text Add to dashboard Cite

show abstract

“…There were no reports of adverse effects in either supplement groups. Although epidemiological data suggested that consumption of whole milk may increase the risk for PD, the mechanistic explanation is probably not a direct effect of the milk proteins, but rather a reduction of serum uric acid following consumption of a high volume of dairy products [49].…”

Section: Accepted Manuscriptmentioning

confidence: 97%

Biochemical and clinical effects of Whey protein supplementation in Parkinson's disease: A pilot study

Tosukhowong

Boonla

Dissayabutra

et al. 2016

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…Evidence gathered by epidemiological studies have significantly contributed towards a better understanding related to the various factors which are neuroprotective as well as those which may increase the risk associated with the disease progression [9], which provides an idea to look into the linkage between nutrition and reducing the burden of PD.…”

Section: Introductionmentioning

confidence: 99%

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Muralidhara¹,

Sv²,

SC³

2017

J Aging Sci

View full text Add to dashboard Cite

Various nutritional components belonging to different classes of natural dietary origin display modulatory (protective) properties against age-related neurodegenerative disorders (NDD) such as Parkinson's disease (PD) and Alzheimer's disease. These compounds termed as nutraceuticals which have been shown to act at various biochemical and metabolic levels and exhibit different degree of neuroprotective properties. Present review aims to summarize the current status on the modulatory impact of some of the major nutritional compounds on the pathophysiology of PD, the second most common NDD in humans. Primarily, we have examined the data demonstrated in animal models and postulated through epidemiological studies on the compounds/molecules/life style factors which reduce the risk associated with PD and probable mechanism/s through which they elicit neuroprotection. Further we also included some of the conflicting information about the compounds which may enhance the risk associated with PD. Additionally, emphasis is also given about the new approaches to understand the impact of nutrition on the epigenome in relation to the development of NDD with a short note on emerging ideas relating to nutritional genomics.

show abstract

The emerging role of nutrition in Parkinson's disease

Cited by 174 publications

References 246 publications

Splice Variant Biomarkers for Parkinson's Disease

Splice Variant Biomarkers for Parkinson's Disease

Biochemical and clinical effects of Whey protein supplementation in Parkinson's disease: A pilot study

Current Understanding on the Beneficial Role of Nutrition in Parkinson’s Disease –An Overview

Contact Info

Product

Resources

About