Comments on: Antineutrophil cytoplasmic autoantibody associated vasculitis-Clinical profile and outcomes

Handa, Rohini

doi:10.4103/injr.injr_81_18

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…When considering the clinical characteristics and phenotype of our cohort, we identified a higher incidence of GPA in Indo-Asian patients. Similar findings have been identified in studies from India, which showed a significantly higher incidence of PR3 ANCA positivity and patients presenting with GPA compared to MPA or eGPA [15,33]. This is in contrast to neighboring Asian counties such as China and Japan, which report higher prevalence of MPO ANCA positivity and MPA (Figure 1).…”

Section: Discussionsupporting

confidence: 87%

“…We aimed to look at the phenotypes and clinical outcomes of Indo-Asian patients with AAGN from two centers in the North West, UK. [15,17,22,[24][25][26][27][28][29][30][31][32][33][34]. Adapted from Watts et al [35] and Kitching et al [36].…”

Section: Introductionmentioning

confidence: 99%

“…Adapted from Watts et al [35] and Kitching et al [36]. [15,17,22,[24][25][26][27][28][29][30][31][32][33][34]. Adapted from Watts et al [35] and Kitching et al [36].…”

Section: Introductionmentioning

confidence: 99%

“…Figure 1. Global epidemiology of MPO (yellow) and PR3 (purple) predominance of ANCA-associated vasculitis[15,17,22,[24][25][26][27][28][29][30][31][32][33][34]. Adapted from Watts et al[35] and Kitching et al[36].…”

mentioning

confidence: 99%

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Clinical Phenotype and Outcomes of Indo-Asian Patients with ANCA-Associated Glomerulonephritis in the North West, UK

Floyd,

Storrar,

Pramanik

et al. 2023

Kidney and Dialysis

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ANCA-associated vasculitides (AAV) are rare, autoimmune conditions associated with end-stage kidney disease (ESKD) and mortality. Data have predominately been from White populations of European ancestry although geographical differences are well documented. Few studies have looked at the incidence, phenotype and clinical outcomes of ethnic minority patients, in particular Indo-Asian populations. A two-center, retrospective cohort study was conducted of patients with ANCA-associated glomerulonephritis (AAGN), self-identifying as Indo-Asian in the North West, UK between 2009 and 2023. A control group of White patients was identified from the same databases and recruited consecutively in relation to the original cohort of Indo-Asian patients. A total of 66 patients were included, 24 patients of Indo-Asian ethnicity and a control cohort of 42 patients of White ethnicity. Indo-Asian patients had a lower median age at diagnosis (53.0 vs. 57.5 years, p = 0.15) and there was an increased prevalence of diabetes mellitus (33.3% vs. 4.8%, p = 0.002) and a higher incidence of previous TB exposure (12.5% vs. 0%, p = 0.019). Outcomes including relapse, ESKD and mortality were similar. We demonstrated an increased crude incidence of AAGN in Indo-Asian patients in the UK compared to similar epidemiological studies. Consideration needs to be given to epidemiological and genetic research, achieved by collaboration and broader recruitment in clinical trials.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

“…Adapted from Watts et al [35] and Kitching et al [36]. [15,17,22,[24][25][26][27][28][29][30][31][32][33][34]. Adapted from Watts et al [35] and Kitching et al [36].…”

Section: Introductionmentioning

confidence: 99%