Comments from the Behavioral Teratology Committee of the Japanese Teratology Society on OECD Guideline for the Testing of Chemicals, Proposal for a New Guideline 426, Developmental Neurotoxicity Study, Draft Document (September 2003)

Abstract

In September 2003, a new revision of the draft guideline (Organization for Economic Co-operation and Development [OECD] Guideline for the Testing of Chemicals, Proposal for a New Guideline 426, Developmental Neurotoxicity Study) was distributed. The draft guideline consists of 51 paragraphs and an appendix. The National Coordinators were requested to arrange national expert reviews of the guideline proposal in their member countries. The member of the Behavioral Teratology (BT) Committee of the Japanese Teratology Society (JTS) reviewed, discussed and commented on the draft Test Guideline proposal. The BT Committee of the JTS also commented that the International Collaborative Study to validate this protocol should be definitely performed. These comments were sent to the OECD Secretariat. The BT Committee of the JTS expects that the comments are useful for further discussion.

Evaluation of In vivo Antitrypanosomal Activity of Aqueous and Methanol Leaf Extracts of Clutia abyssinica (Euphorbiaceae) against Trypanosoma congolense Field Isolate

“…Animals were housed in polypropylene cages (6-10 animals per cage), maintained less than 12 hr light and 12 hr dark cycle and allowed free access to pellet diet and clean water ad libitum. All procedures complied with the guide for the care and use of laboratory animals [23].…”

Comments from the Developmental Neurotoxicology Committee of the Japanese Teratology Society on the OECD Guideline for the Testing of Chemicals, Proposal for a New Guideline 426, Developmental Neurotoxicity Study, Draft Document (October 2006 version), and on the Draft Document of the Retrospective Performance Assessment of the Draft Test Guideline 426 on Developmental Neurotoxicity

“…Activities of the BTM of the Japanese Teratology Society had continued to be presented as the Behavioral Teratology Committee (present DNT Committee) until July 2006. For instance, comments on the OECD Test Guideline 426, Developmental Neurotoxicity Study, Draft Document (September, 2003) were published (Fukui et al 2004).…”

“…The following five references for the New P19 are to be added. Fukui Y, Ema M, Fujiwara M et al (2004) Note: 'Congenital Anomalies' is the official journal of the Japanese Teratology Society. It has been recently adopted by PubMed and the abbreviated title in PubMed is 'Congenit Anom Kyoto'.…”

“…The draft guideline consists of 51 paragraphs and an appendix. The BT Committee of the JTS commented on the draft Test Guideline Proposal (Fukui et al . 2004).…”

“…The draft guideline consists of 51 paragraphs and an appendix. The BT Committee of the JTS commented on the draft Test Guideline Proposal (Fukui et al 2004). The BT Committee of the JTS also commented that an International Collaborative Study to validate this protocol should definitely be performed, as indicated in OECD ENV/EHS/HK/mc/2003.49.…”