Comments -- Beta-blockers: Heart rate reduction a mechanism of benefit

Kjekshus, J.

doi:10.1093/eurheartj/6.suppl_a.29

Cited by 35 publications

(3 citation statements)

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“…It is known that therapy with β-adrenergic blocking agents, when begun shortly after acute myocardial infarction, decreases mortality [42,43]. In a large, prospective, randomized, double-blind trial, the difference in heart rate between the groups treated with β-blockers and the placebo groups was directly related to the reduction in mortality [42] (fig.…”

Section: Heart Rate and Survival After Therapeutic Interventionsmentioning

confidence: 99%

“…In a large, prospective, randomized, double-blind trial, the difference in heart rate between the groups treated with β-blockers and the placebo groups was directly related to the reduction in mortality [42] (fig. 8a).…”

Section: Heart Rate and Survival After Therapeutic Interventionsmentioning

confidence: 99%

“…8 a Relationship between reduction in heart rate due to therapy with β-blocking agents and reduction in mortality in large, prospective, randomized trials on patients with coronary artery disease [42]. b Relationship between increase in diastolic time due to therapy with β-blocking agents and reduction in mortality in patients with coronary artery disease in large, prospective, randomized trials [13].…”

Section: Heart Rate and Survival After Therapeutic Interventionsmentioning

confidence: 99%

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Heart Rate, Life Expectancy and the Cardiovascular System: Therapeutic Considerations

Boudoulas¹,

Borer²,

Boudoulas³

2015

Cardiology

1,245

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It has long been known that life span is inversely related to resting heart rate in most organisms. This association between heart rate and survival has been attributed to the metabolic rate, which is greater in smaller animals and is directly associated with heart rate. Studies have shown that heart rate is related to survival in apparently healthy individuals and in patients with different underlying cardiovascular diseases. A decrease in heart rate due to therapeutic interventions may result in an increase in survival. However, there are many factors regulating heart rate, and it is quite plausible that these may independently affect life expectancy. Nonetheless, a fast heart rate itself affects the cardiovascular system in multiple ways (it increases ventricular work, myocardial oxygen consumption, endothelial stress, aortic/arterial stiffness, decreases myocardial oxygen supply, other) which, in turn, may affect survival. In this brief review, the effects of heart rate on the heart, arterial system and survival will be discussed.

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Section: Heart Rate and Survival After Therapeutic Interventionsmentioning

confidence: 99%

Section: Heart Rate and Survival After Therapeutic Interventionsmentioning

confidence: 99%

Section: Heart Rate and Survival After Therapeutic Interventionsmentioning

confidence: 99%

See 1 more Smart Citation

Heart Rate, Life Expectancy and the Cardiovascular System: Therapeutic Considerations

Boudoulas¹,

Borer²,

Boudoulas³

2015

Cardiology

1,245

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β-Blockers and Primary Prevention of Coronary Heart Disease in Patients With High Blood Pressure

Psaty

Koepsell

LoGerfo

et al. 1989

JAMA

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We conducted a population-based, case-control study to determine whether beta-blockers, used for the treatment of hypertension, prevent first events of coronary heart disease. Cases were patients who had high blood pressure treated with medicines and who presented in 1982 to 1984 with angina or fatal or nonfatal myocardial infarction. Controls were a probability sample of health maintenance organization patients with pharmacologically treated hypertension and free of coronary heart disease. Blinded to case-control status, we reviewed the medical records of the 248 cases and 737 controls. The health maintenance organization's computerized pharmacy database was used to ascertain the use of beta-blockers. Fewer cases than controls were taking beta-blockers. This difference was confined to those with nonfatal infarctions. After adjustment for confounding, the estimated relative risk was 0.62 (95% confidence interval, 0.39 to 0.99). Higher doses of beta-blockers conferred greater protection. We conclude that beta-blockers may prevent first events of nonfatal myocardial infarction in patients with high blood pressure.

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Obtaining medically meaningful answers from an overview of randomized clinical trials

Yusuf

1987

Statistics in Medicine

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Answers that have medical value can often be obtained from overviews of randomized clinical trials if care is taken in formulating a biologically sensible question and unbiased and careful methods are used in collecting, extracting and analysis the results. This article discusses some of the pitfalls that are encountered during this process, outlines some solutions and emphasizes the need for a conservative interpretation of the results.

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Comments -- Beta-blockers: Heart rate reduction a mechanism of benefit

Cited by 35 publications

References 0 publications

Heart Rate, Life Expectancy and the Cardiovascular System: Therapeutic Considerations

Heart Rate, Life Expectancy and the Cardiovascular System: Therapeutic Considerations

β-Blockers and Primary Prevention of Coronary Heart Disease in Patients With High Blood Pressure

Obtaining medically meaningful answers from an overview of randomized clinical trials

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