Commentary: Oxygen regulation of breathing through an olfactory receptor activated by lactate

Santillo, Mariarosaria; Damiano, Simona

doi:10.3389/fnins.2016.00213

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Hypoxia inhibits mitochondrial electron transport chain (ETC) in CB glomus cells, leading to a decrease in mitochondrial oxidative phosphorylation (Kumar & Prabhakar, ; Liao et al, ). Moreover, the inhibition of ETC causes accumulation of pyruvate, which is quickly converted to lactate in CB glomus cells (Chang et al, ; Santillo & Damiano, ). Besides, members of the hypoxia‐inducible factors pathway are discovered in CB glomus cells (Kalbe et al, ).…”

Section: Prospectionmentioning

confidence: 99%

The diversified function and potential therapy of ectopic olfactory receptors in non‐olfactory tissues

Chen

Zhao

et al. 2017

Journal Cellular Physiology

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Olfactory receptors (ORs) are mainly distributed in olfactory neurons and play a key role in detecting volatile odorants, eventually resulting in the production of smell perception. Recently, it is also reported that ORs are expressed in non-olfactory tissues including heart, lung, sperm, skin, and cancerous tissues. Interestingly, ectopic ORs are associated with the development of diseases in non-olfactory tissues. For instance, ectopic ORs initiate the hypoxic ventilatory responses and maintain the oxygen homeostasis of breathing in the carotid body when oxygen levels decline. Ectopic ORs induce glucose homeostasis in diabetes. Ectopic ORs regulate systemic blood pressure by increasing renin secretion and vasodilation. Ectopic ORs participate in the process of tumor cell proliferation, apoptosis, metastasis, and invasiveness. Ectopic ORs accelerate the occurrence of obesity, angiogenesis and wound-healing processes. Ectopic ORs affect fetal hemoglobin levels in sickle cell anemia and thalassemia. Finally, we also elaborate some ligands targeting for ORs. Obviously, the diversified function and related signal pathway of ectopic ORs may play a potential therapeutic target in non-olfactory tissues. Thus, this review focuses on the latest research results about the diversified function and therapeutic potential of ectopic ORs in non-olfactory tissues.

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