Commentary: Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy

Jørgensen, Silje Fjellgård; Fevang, Børre; Aukrust, Pål

doi:10.3389/fimmu.2020.01921

Cited by 5 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with celiac disease, the GFD over two years may also alter the gut microbiota profile, decreasing Bifidobacteria and Lactobacilli and increasing potential Enterobacteriaceae pathobionts. Jorgensen and colleagues have debated the clinical relevance of CD19 −/− mice as a CVID model [ 107 ]. This mouse model does not represent the polygenic etiology of the majority of CVID patients.…”

Section: Dietary and Supplementary Interventionsmentioning

confidence: 99%

Is there a role for microbiome-based approach in common variable immunodeficiency?

et al. 2023

View full text Add to dashboard Cite

Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low levels of serum immunoglobulins and increased susceptibility to infections, autoimmune disorders and cancer. CVID embraces a plethora of heterogeneous manifestations linked to complex immune dysregulation. While CVID is thought to be due to genetic defects, the exact cause of this immune disorder is unknown in the large majority of cases. Compelling evidences support a linkage between the gut microbiome and the CVID pathogenesis, therefore a potential for microbiome-based treatments to be a therapeutic pathway for this disorder. Here we discuss the potential of treating CVID patients by developing a gut microbiome-based personalized approach, including diet, prebiotics, probiotics, postbiotics and fecal microbiota transplantation. We also highlight the need for a better understanding of microbiota-host interactions in CVID patients to prime the development of improved preventive strategies and specific therapeutic targets.

show abstract

Section: Dietary and Supplementary Interventionsmentioning

confidence: 99%

Is there a role for microbiome-based approach in common variable immunodeficiency?

et al. 2023

View full text Add to dashboard Cite

show abstract

“…However, in mice-studies, the host-microbe interaction has been studied in more detail showing that microbes can regulate both immune and metabolic pathways ( 107 – 110 ). Due to the heterogeneity of CVID, no mouse model exists to study the host-microbe interaction in this disorder ( 111 ), and therefore all microbiota studies in CVID are in humans. A decade ago Shulzhenko et al.…”

Section: Gut Microbial Dysbiosis: a Potential Player In The Dysregula...mentioning

confidence: 99%

Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances

et al. 2023

Self Cite

View full text Add to dashboard Cite

The relationship between metabolic and inflammatory pathways play a pathogenic role in various cardiometabolic disorders and is potentially also involved in the pathogenesis of other disorders such as cancer, autoimmunity and infectious diseases. Common variable immunodeficiency (CVID) is the most common primary immunodeficiency in adults, characterized by increased frequency of airway infections with capsulated bacteria. In addition, a large proportion of CVID patients have autoimmune and inflammatory complications associated with systemic inflammation. We summarize the evidence that support a role of a bidirectional pathogenic interaction between inflammation and metabolic disturbances in CVID. This include low levels and function of high-density lipoprotein (HDL), high levels of triglycerides (TG) and its major lipoprotein very low-density lipoprotein (VLDL), and an unfavorable fatty acid (FA) profile. The dysregulation of TG, VLDL and FA were linked to disturbed gut microbiota profile, and TG and VLDL levels were strongly associated with lipopolysaccharides (LPS), a marker of gut leakage in blood. Of note, the disturbed lipid profile in CVID did not include total cholesterol levels or high low-density lipoprotein levels. Furthermore, increased VLDL and TG levels in blood were not associated with diet, high body mass index and liver steatosis, suggesting a different phenotype than in patients with traditional cardiovascular risk such as metabolic syndrome. We hypothesize that these metabolic disturbances are linked to inflammation in a bidirectional manner with disturbed gut microbiota as a potential contributing factor.

show abstract

“…Intestinal microbes promote the production of antibodies by B cells through activation of TLR, contributing to the progression of atherosclerotic disease ( Chen et al, 2016 ). Although IgM and other antibodies have compensatory effects in the gut, IgA-deficient mice are prone to intestinal microecological disturbances that induce chronic intestinal inflammation, which also increases the risk of metabolic disease ( Jorgensen et al, 2020 ). B cells control intestinal inflammation by releasing IL-10 ( Rosser and Mauri, 2015 ).…”

Section: Role Of Gut Microbiota and Their Metabolites In The Immune M...mentioning

confidence: 99%

Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases

Jin

Yang

et al. 2022

Front. Microbiol.

View full text Add to dashboard Cite

The risk of cardiovascular disease (CVD) is associated with unusual changes in the human gut microbiota, most commonly coronary atherosclerotic heart disease, hypertension, and heart failure. Immune mechanisms maintain a dynamic balance between the gut microbiota and the host immune system. When one side changes and the balance is disrupted, different degrees of damage are inflicted on the host and a diseased state gradually develops over time. This review summarizes the immune mechanism of the gut microbiota and its metabolites in the occurrence of common CVDs, discusses the relationship between gut-heart axis dysfunction and the progression of CVD, and lists the currently effective methods of regulating the gut microbiota for the treatment of CVDs.

show abstract

Commentary: Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy

Cited by 5 publications

References 17 publications

Is there a role for microbiome-based approach in common variable immunodeficiency?

Is there a role for microbiome-based approach in common variable immunodeficiency?

Disturbed lipid profile in common variable immunodeficiency – a pathogenic loop of inflammation and metabolic disturbances

Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases

Contact Info

Product

Resources

About