Commentary: del Nido versus blood cardioplegia for aortic valve replacement: The choice is yours. Proceed with caution

Abstract

Cold blood versus del Nido solutions and techniques of administration require continued investigation. Central Message This study with the accumulating clinical evidence continues to demonstrate the equivalent degree of myocardial protection for del Nido solution compared with cold blood cardioplegia. The exposure to subsets of patients with low EF and requiring complex surgery requires broader clinical experience.

Single-Dose Del Nido Cardioplegia vs. Blood Cardioplegia in Aortic Valve Replacement Surgery

“…Conditions requiring aortic valve replacement (aortic stenosis and aortic regurgitation) should also be subject to a separate assessment in terms of their effects on the left ventricle 3 , 4 . However, there is still a limited number of data associated with the use of DNC in aortic valve replacement 5 , 6 . The aim of this study is to contribute to the literature by comparing the results of DNC and BC delivery during aortic valve replacement in adult patients.…”

Del Nido cardioplegia: Questions and (some) answers

“…As a result, numerous publications have warned of the lack of evidence for del Nido cardioplegia use in patients with low ejection fraction, or those undergoing complex operations excluded from randomized trials. 9,12 These editorials emphasize a few central points. First, whereas del Nido cardioplegia appears to be safe in patients with minimal comorbidities undergoing isolated CABG or valve operations with short ischemic times, use in patients with comorbidities, reduced ejection fraction, right ventricular dysfunction, and prolonged ischemic times is not established.…”