Del Nido cardioplegia: Questions and (some) answers

Waterford, Stephen D.; Ad, Niv

doi:10.1016/j.jtcvs.2021.11.053

Cited by 6 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Magnetic resonance imaging (MRI) likely represents the most thorough method to assess myocardial protection with special attention to the subendocardial myocardium and its viability. The recommendation that postoperative MRI scan be done from postoperative days 5 to 7 or another standardized time range to assess myocardial protection was proposed in future randomized trials of del Nido cardioplegia versus conventional cardioplegia [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Del Nido cardioplegia versus cold blood cardioplegia in adult cardiac surgery: a meta-analysis of randomized clinical trials

Li,

Xiang,

Yang

et al. 2024

J Cardiothorac Surg

View full text Add to dashboard Cite

Objective Systematic evaluation of the safety of del Nido cardioplegia compared to cold blood cardioplegia in adult cardiac surgery. Methods We systematically searched PubMed, EMbase, The Cochrane Library and ClinicalTrials.gov for randomized clinical trials (published by 14 January 2024) comparing del Nido cardioplegia to cold blood cardioplegia in adult. Our main endpoints were myocardial injury markers and clinical outcomes. We assessed pooled data by use of a random-effects model or a fixed-effects model. Results A total of 10 studies were identified, incorporating 889 patients who received del Nido cardioplegia and 907 patients who received cold blood cardioplegia. The meta-analysis results showed that compared with the cold blood cardioplegia, the del Nido cardioplegia had less volume of cardioplegia, higher rate of spontaneous rhythm recovery after cross clamp release, lower levels of postoperative cardiac troponin T and creatinine kinase-myocardial band, all of which were statistically significant. However, there was no statistically significant difference in postoperative troponin I and postoperative left ventricular ejection fraction. The clinical outcomes including mechanical ventilation time, intensive care unit stay time, hospital stay time, postoperative stroke, postoperative new-onset atrial fibrillation, postoperative heart failure requiring intra-aortic balloon pump mechanical circulation support, and in-hospital mortality of both are comparable. Conclusion Existing evidence suggests that del Nido cardioplegia reduced volume of cardioplegia administration and attempts of defibrillation. The superior postoperative results in CTnT and CK-MB may provide a direction for further research on improvement of the composition of cardioplegia. Visual Abstract

show abstract

Section: Discussionmentioning

confidence: 99%

Del Nido cardioplegia versus cold blood cardioplegia in adult cardiac surgery: a meta-analysis of randomized clinical trials

Li,

Xiang,

Yang

et al. 2024

J Cardiothorac Surg

View full text Add to dashboard Cite

show abstract

“… 13 In operations with prolonged crossclamp time (CCT), however, there is no consensus regarding timing, quantity, and route of additional doses. 14 By our knowledge, fewer than 40 operations using DN with CCT greater than 3 hours have been shared in literature.…”

mentioning

confidence: 99%