Commentary: Acute kidney injury: The one-million-pieces puzzle

Bacco, Lorenzo Di; Montisci, Andrea; Miceli, Antonio

doi:10.1016/j.jtcvs.2018.11.122

Cited by 3 publications

(1 citation statement)

References 10 publications

(13 reference statements)

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“…The renal ischemia/reperfusion (I/R) injury is one of the major causes of Acute Kidney Injury (AKI), which is mostly induced by transplantation, cardiopulmonary resuscitation, shock, contrast nephropathy and other events [1][2][3][4][5]. Due to the poor prognosis and lack of effective therapy, AKI is markedly associated with a high morbidity and mortality [6,7].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of EET on Renal I/R through NLRP3 and Pyroptosis

Zhu¹,

Ding²,

Yang³

et al. 2019

Int J Nephrol Kidney Fail

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Volume 5 -Issue 4Epoxyeicosatrienoic acids (EETs), metabolized from arachidonic acid through the cytochrome P450 epoxygenases pathway, have such protective effects of vasodilation, anti-inflammation and antiapoptosis in the treatment of multiple diseases [13][14][15]. Our previous evidence showed that EETs can alleviate inflammatory cell infiltration induced by renal I/R [16][17][18]. In this study, male C57/BL6 mice were used to establish I/R-induced AKI model with the pre-administration of 14,15-EET. The expression of NLRP3, cleaved cysteinyl aspartate specific proteinase 1 (cleaved-caspase-1), interleukin-1β (IL-1β) and so on were measured to analyze the effect and mechanism of EET on renal I/R-related inflammatory response, which may be developed a novel and useful treatment to improve AKI.

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