Comment: Sodium-Glucose Cotransporters as Potential Therapeutic Targets in Patients With Type 1 Diabetes Mellitus: An Update on Phase 3 Clinical Trial Data

Cüre, Medine Cumhur; Cüre, Erkan

doi:10.1177/1060028020910204

Cited by 4 publications

(5 citation statements)

References 5 publications

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“…During anaerobic conditions, e.g. compromised tissue oxygenation that the virus causes, the pathway for lactate formation from pyruvate is favored (107,108); and resulting elevated levels of lactate stimulate secretion of pro-inflammatory mediators and OS (105). Dapagliflozin, a member of this class, has been shown to reduce levels of lactate.…”

Section: Sglt2 Inhibitors Effect In Relation To Lactatementioning

confidence: 99%

Impact of Antidiabetic Drugs on Risk and Outcome of Covid-19 Infection: A Review

Zainal¹,

Merkhan²

2022

Mil. Med. Sci. Lett.

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Based on many reports, an unmistakable link probably exists between diabetes mellitus and COVID-19. A major predisposing factor determining severity and mortality of COVID-19 is diabetes mellitus, diabetic patients were shown to be at higher risk for developing severe COVID-19 disease than non-diabetics; many recent studies reported a striking prevalence of DM in those diagnosed with COVID-19. Accordingly, antidiabetic drugs can possibly impact the clinical course and / or the outcome of this infection, either by alleviating diabetes-associated symptoms, minimizing its complications, or by mitigating or aggravating COVID-19 disease by effects independent from their direct antidiabetic effects. Several antidiabetic drug classes were shown to have varying effects, like blocking viral entry to cells, as well as having immunomodulatory, anti-inflammatory, antifibrotic, or cardioprotective effects; such effects could prove beneficial for COVID-19 patients. On the other hand, some antidiabetic agents may have adverse effects that aggravate patients' condition like hypoglycemia, fluid retention, increased weight or lactic acidosis, which require special consideration in patient management. Some of the drugs were found in observational studies to either reduce mortality from COVID-19 or pose no harm, but more solid evidence from clinical trials is still lacking.

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Section: Sglt2 Inhibitors Effect In Relation To Lactatementioning

confidence: 99%

Impact of Antidiabetic Drugs on Risk and Outcome of Covid-19 Infection: A Review

Zainal¹,

Merkhan²

2022

Mil. Med. Sci. Lett.

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“…In aerobic conditions, lactate converts into pyruvate with lactate dehydrogenase enzyme and enters the TCA cycle. Since tissue oxygenation is disturbed, the hypoxic environment is formed [5,6]. When anaerobic conditions develop, lactate formation increases from pyruvate.…”

Section: Dear Sirmentioning

confidence: 99%

“…The virus can create such a high anaerobic environment by disrupting tissue oxygenation. [5,6]. Energy production in the hypoxic environment is achieved through anaerobic glycolysis and 2 lactate and 2 H þ ions are obtained.…”

Section: Dear Sirmentioning

confidence: 99%

Can dapagliflozin have a protective effect against COVID-19 infection? A hypothesis

Cüre¹,

Cüre²

2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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“…A vicious cycle continues, and lactate production continues to increment as the hypoxic and acidic environment increases. In addition, elevated lactate levels increase the release of proinflammatory cytokines and oxidative stress [140].…”

Section: Lactic Dehydrogenasementioning

confidence: 99%

The coronavirus disease 2019 and effect on liver function: a hidden and vital interaction beyond the respiratory system

Hosseini

Afzali

Karimi

et al. 2021

Reviews in Medical Microbiology

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Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) emerged in December 2019 in Wuhan province, China. SARS-CoV-2 causes coronavirus disease 2019 . Angiotensin-converting enzyme 2 (ACE2) has an essential role as a receptor in the entry of the SARS-CoV-2 into the host cells. It has been declared, ACE2 expresses in the lungs, heart, kidneys, placenta, and liver. This study reviews the liver's markers' characteristics in patients with COVID-19 to achieve novel insights in improving clinical treatment. Liver disease and chronic kidney disease patients are susceptible to COVID-19. There is limited information about the effects of SARS-COV-2 on patients with preexisting liver associated disorders, including chronic hepatitis B virus or hepatitis C virus, primary biliary cirrhosis, nonalcoholic fatty liver disease, and more are yet to be understood. By considering conducted studies in this manner since ACE2 receptors, which are the primary receptors for SRAS-CoV-2, exist on the liver and lungs, heart, kidneys, and placenta, SRAS-CoV-2 can infect liver cells too. Consequently, this infection will have resulted in liver function tests' escalated levels and total bilirubin as biochemical biomarkers. Further investigations need to be done to point out the hepatic manifestations of COVID-19's infected patients with chronic liver disease and improve clinical management and more stringent preventive measures for this type of infected patients.

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Comment: Sodium-Glucose Cotransporters as Potential Therapeutic Targets in Patients With Type 1 Diabetes Mellitus: An Update on Phase 3 Clinical Trial Data

Cited by 4 publications

References 5 publications

Impact of Antidiabetic Drugs on Risk and Outcome of Covid-19 Infection: A Review

Impact of Antidiabetic Drugs on Risk and Outcome of Covid-19 Infection: A Review

Can dapagliflozin have a protective effect against COVID-19 infection? A hypothesis

The coronavirus disease 2019 and effect on liver function: a hidden and vital interaction beyond the respiratory system

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