Comment on ‘Vitiligo in a COVID‐19‐vaccinated patient with ulcerative colitis: coincidence?’: Type I interferons as possible link between COVID‐19 vaccine and vitiligo

Safety of SARS-CoV-2 vaccination in patients with inflammatory bowel disease: A systematic review and meta-analysis

“…The details of the included studies are illustrated in Table 1 [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] . The details of the excluded studies with the reason for exclusion is shown in Supplementary Table 2 [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] .

Figure 1 PRISMA flow chart depicting the study screening and selection of the systematic review

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Eruptive halo nevi: A new COVID‐19 vaccine‐related cutaneous adverse event or a paraneoplastic phenomenon?

“…In particular, given that vaccination against Covid‐19 promotes the production of type 1 interferons (IFN‐I) by stimulating the recruitment of plasmacytoid dendritic cells, 13 it has been proposed that vaccine‐induced IFN‐I production may serve as a trigger to vitiligo in genetically predisposed individuals. 14 Remarkably, the onset of multiple halo nevi has been reported in a 22‐year‐old female with multiple sclerosis treated with IFNβ‐1a a few weeks after therapy was started. 15 …”

Vitiligo worsened following the second dose of mRNA SARS‐CoV ‐2 vaccine

“…About vitiligo, Abdullah et al hypothesized that the link between SARS‐CoV‐2 vaccination and vitiligo may be the type 1 interferon (IFN‐1) produced by dendritic plasmacytoid cells (pDC). 9 …”

“…8 About vitiligo, Abdullah et al hypothesized that the link between SARS-CoV-2 vaccination and vitiligo may be the type 1 interferon (IFN-1) produced by dendritic plasmacytoid cells (pDC). 9 The activation of pDCs, in fact, induces a high production of IFN-1. The activation of such cells can be induced by viral nucleic acid sequences through toll-like receptors (TLRs) 7 and 9.…”