Eruptive halo nevi: A new COVID‐19 vaccine‐related cutaneous adverse event or a paraneoplastic phenomenon?

Abstract

Halo nevi, also known as Sutton nevi, are characterized by the development of a rim of depigmentation around a nevus. These nevi usually occur in healthy children or young adults as single lesions and are considered benign entities, whereas in adults, the sudden appear-

Rapid regression of multiple melanocytic nevi in an individual with history of melanoma with the CDKN2A mutation

“… 4 Furthermore, an interesting case report shows an eruption of multiple halo nevi in correlation with the SARS-CoV-2 vaccine, suggesting a potential role in triggering this sudden eruption. 5 While the presence of an underlying melanoma triggering SR in this patient cannot be entirely excluded, it is less favored after seeking a second dermatopathology opinion for the nevi illustrated in Figs 1 and 2 , which agreed that features of melanoma were not present. The absence of pre-2022 nevus photos presents a challenge in assessing any regression reaction.…”

Halo Phenomenon in Lobular Capillary Hemangioma: A Case Report of a Pyogenic Granuloma With Surrounding Cutaneous Hypopigmentation and Review of Tumors With Halo Phenomenon

“…Some of these cutaneous disorders include granulomatous diseases (such as sarcoidosis), infection-related non-specific lesions (such as syphilis), and papulosquamous diseases (such as lichen planus and psoriasis) [3]. In addition, benign and malignant lesions have been described that demonstrate the halo phenomenon (Table 1) [1][2][3][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

“…Fibrous lesion b [6] Keratinocyte malignancy c [3] Melanocytic neoplasm [2,[7][8][9][10][11][12] Vascular lesion d [13][14][15][16][17][18][19][20]…”

“…The clinical and pathological features of her lobular capillary hemangioma with halo phenomenon are discussed. In addition, other cutaneous neoplasms in which the halo phenomenon has been observed are reviewed [1][2][3][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

A case of eruptive halo nevi following COVID‐19

“…In the literature, there are cases of vitiligo developing after COVID-19 and after COVID-19 vaccines. [3][4][5][6] Although a case of eruptive halo nevi after the COVID-19 vaccine took our attention in the literature, 7 as far as we know, there has been no case of halo or eruptive halo nevi developing after COVID-19 yet. The similarity of the skin findings following infection and vaccination suggests that it results from an immune response rather than the virus.…”