“…Otherwise, GCA and TAK differ in terms of age of onset (GCA > 50 years, TAK most commonly < 40 years), sex predominance (females even more commonly affected in TAK than in GCA), distribution of arterial lesions, treatment, and prognosis. Histopathology shows granulomatous inflammation [ 1 ], and imaging of extracranial arteries often displays involvement of the aorta and its branches in both entities [ 2 – 4 ]. Differentiating between GCA and TAK is important, as recent studies have shown different treatment responses in GCA and TAK to the same biologic therapies [ 5 , 6 ], indicating the importance of correct diagnosis.…”
Purpose of Review
To discuss and summarize the latest evidence on imaging techniques in giant cell arteritis (GCA) and Takayasu arteritis (TAK). This is a report on the performance of ultrasound (US), magnetic resonance imaging (MRI), computed tomography (CT), 18F-fluorodeoxyglucose positron emission tomography (18-FDG-PET), and other emerging imaging techniques in diagnosis, outcome prediction, and monitoring of disease activity.
Recent Findings
Imaging techniques have gained an important role for diagnosis of large vessel vasculitides (LVV). As signs of vasculitis, US, MRI, and CT show a homogeneous arterial wall thickening, which is mostly concentric. PET displays increased FDG uptake in inflamed artery walls. US is recommended as the initial imaging modality in GCA. MRI and PET/CT may also detect vasculitis of temporal arteries. For TAK, MRI is recommended as the first imaging modality as it provides a good overview without radiation. Extracranial LVV can be confirmed by all four modalities. In addition, MRI and PET/CT provide consistent examination of the aorta and its branches. New techniques such as contrast-enhanced ultrasound, PET/MRI, and auxiliary methods such as “computer-assisted quantitative analysis” have emerged and need to be further validated.
Summary
Imaging has partly replaced histology for confirming LVV. Provided experience and adequate training, US, MRI, CT, or PET provide excellent diagnostic accuracy. Imaging results need to complement history and clinical examination. Ongoing studies are evaluating the role of imaging for monitoring and outcome measurement.
“…Otherwise, GCA and TAK differ in terms of age of onset (GCA > 50 years, TAK most commonly < 40 years), sex predominance (females even more commonly affected in TAK than in GCA), distribution of arterial lesions, treatment, and prognosis. Histopathology shows granulomatous inflammation [ 1 ], and imaging of extracranial arteries often displays involvement of the aorta and its branches in both entities [ 2 – 4 ]. Differentiating between GCA and TAK is important, as recent studies have shown different treatment responses in GCA and TAK to the same biologic therapies [ 5 , 6 ], indicating the importance of correct diagnosis.…”
Purpose of Review
To discuss and summarize the latest evidence on imaging techniques in giant cell arteritis (GCA) and Takayasu arteritis (TAK). This is a report on the performance of ultrasound (US), magnetic resonance imaging (MRI), computed tomography (CT), 18F-fluorodeoxyglucose positron emission tomography (18-FDG-PET), and other emerging imaging techniques in diagnosis, outcome prediction, and monitoring of disease activity.
Recent Findings
Imaging techniques have gained an important role for diagnosis of large vessel vasculitides (LVV). As signs of vasculitis, US, MRI, and CT show a homogeneous arterial wall thickening, which is mostly concentric. PET displays increased FDG uptake in inflamed artery walls. US is recommended as the initial imaging modality in GCA. MRI and PET/CT may also detect vasculitis of temporal arteries. For TAK, MRI is recommended as the first imaging modality as it provides a good overview without radiation. Extracranial LVV can be confirmed by all four modalities. In addition, MRI and PET/CT provide consistent examination of the aorta and its branches. New techniques such as contrast-enhanced ultrasound, PET/MRI, and auxiliary methods such as “computer-assisted quantitative analysis” have emerged and need to be further validated.
Summary
Imaging has partly replaced histology for confirming LVV. Provided experience and adequate training, US, MRI, CT, or PET provide excellent diagnostic accuracy. Imaging results need to complement history and clinical examination. Ongoing studies are evaluating the role of imaging for monitoring and outcome measurement.
“…В остальном ГКА и АТ различаются по возрасту дебюта (ГКА >50 лет, АТ чаще всего <40 лет), гендерным особенностям (женщины чаще страдают АТ, чем ГКА), распределению поражения артерий, лечению и прогнозу. Морфологическая картина характеризуется наличием гранулематозного воспаления [3], а при визуализации экстракраниальных артерий часто обнаруживают вовлечение аорты и ее ветвей [4,5]. В связи с этим важно дифференцировать ГКА от АТ, поскольку в недавних исследованиях показана различная реакция на одни и те же биологические препараты при этих заболеваниях [6,7], что подчеркивает важность верификации диагноза, режима лечения и прогноза.…”
Large vessel vasculitis (LVV), including Takayasu's arteritis (AT, or non-specific aortoarteritis) and giant cell arteritis (GCA), is caused by granulomatous inflammation affecting mainly the aorta and its main branches. Damage to the vascular wall leads to ischemia of the corresponding organs and can be complicated by loss of vision, cerebral insufficiency and other life-threatening phenomena. The early diagnosis of these diseases in clinical practice is a difficult task that can only be solved by comparing the clinical symptoms, the results of the physical, laboratory and instrumental examination and the vascular biopsy.A comparative analysis of the 2018 and 2023 EULAR recommendations for imaging in LVV is presented. Duplex ultrasound (USDS) of not only temporal but also axillary arteries is recommended for GCA and magnetic resonance imaging (MRI) for AT. Alternative methods for GCA are MRI or positron emission tomography (PET) in combination with computed tomography (CT) and intravenous administration of fluorodeoxyglucose labelled with the short-lived fluoride isotope 18 (FDG-PET/CT), and for AT – FDG-PET/CT, CT or ultrasound examination. MRI, CT or ultrasound can be used for long-term monitoring of structural damage, especially to assess pre-existing vascular inflammation.
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