CoMFA and CoMSIA 3D QSAR Models for a Series of Cyclic Imides with Analgesic Activity

Borchhardt, Deise M.; Andricopulo, Adriano D.

doi:10.2174/157340609787049299

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…1 Besides, Schiff bases have various applications in many fields, including analytical chemistry, corrosion inhibitors, dyes, and ligands for metal complexes [9][10][11]. However, cyclic imides are organic compounds because they have biological activity, such as antibacterial, anticancer, analgesic, anti-inflammatory, and antimicrobial activities [12][13][14][15]. Moreover, cyclic imides are essential building blocks for the synthesis of pharmaceuticals, natural products, polymers, and drugs [16][17].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of New Bis-Schiff Bases Linked to Various Imide Cycles

Yassen

Al-Azzawi

2023

Iraqi Journal of Science

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This research includes the synthesis of new bis-Schiff bases linked to different imide cycles. There were some steps involved in the synthesis of the novel Schiff bases with succinimide, phthalimide, tetrachlorophthalimide, and tetrabromophthalimide cycles. The first step involved the preparation of 4,4`-bis[(4-aminophenyl) methyl benzylidene]tolidine (1) via the condensation reaction of 3,3'-dimethyl-(1,1'-biphenyl)-4,4'-diamine with 4-amino acetophenone. In the second step, compound 1 reacted with various cyclic anhydrides, affording bis-amic acid Schiff bases 2-5. In the third step, the products 2-5 were dehydrated using the fusion method to produce the target bis-imidyl Schiff bases 6-9. This work also involved the synthesis of bis-imidyl Schiff base 10 directly by fusion of compound 1 with 1,8-naphthalic anhydride. The prepared compounds were characterized depending on their FT-IR, 1H NMR, and 13C NMR spectra. The newly synthesized target compounds are expected to be very active biologically since their molecules are essential components of two active groups (imine and imide).

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of New Bis-Schiff Bases Linked to Various Imide Cycles

Yassen

Al-Azzawi

2023

Iraqi Journal of Science

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“…Cyclic imides have been attracted much more attention of organic and medicinal chemists due to their biological activities. Most of them are extensively used as analgesic [7], anti-nociceptive agents [8] or as reactants for polymer synthesis [9]. An imide nucleus can also be found in a structure of anxiolytic, antimicrobial, anticancer and anti-inflammatory substances [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

PGR Evaluation of Novel Synthesized Five and Six Membered Cyclic Imides

Chaudhari¹

2018

IJRASET

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A huge number of cyclic imides have been designed, developed due to their various effective properties. By considering all elevated applications, it was scheduled to design and synthesize the novel class of N-phenyl succinimides and N-phenyl glutarimides. In this article some of the appealing and significant schemes for the making of cyclic imides are epitomized. The five/six membered cyclic imides were synthesized by reacting succinic / glutaric anhydride with different substituted aromatic amines to get 1-(N-methylpyridin-2-yl) pyrrolidine-2, 5/6-dione. During this synthetic route acetyl chloride and water are used as solvent in traditional and green pathways respectively. The beauty of greener exercise helps to replace hazardous solvent acetyl chloride by water. All synthesized compounds were tested as plant growth regulator against maize (Rajeshwar), moong (PKVM-8802). Keywords: Glutaric anhydride, Green pathway, PGR, Succinic anhydride, Traditional pathway I. INTRODUCTIONAs the Green Chemistry movement has gained momentum [1], definitions of Green Chemistry [2-5] have been dominated predominantly. Green Chemistry concepts, however, apply to an incredible diversity of scientific endeavour, which has invariably led to differences between academia and industry. Speaking primarily about the pharmaceutical industry, they have been achieved lot of advances because of Green Chemistry [6]. Cyclic imides have been attracted much more attention of organic and medicinal chemists due to their biological activities. Most of them are extensively used as analgesic [7], anti-nociceptive agents [8] or as reactants for polymer synthesis [9]. An imide nucleus can also be found in a structure of anxiolytic, antimicrobial, anticancer and anti-inflammatory substances [10][11][12]. Cyclic imides comprising the most common heterocyclic elements like nitrogen, oxygen and sulphur plays a vital role in the development of pharmaceutical, medicinal, chemical and agricultural fields [13]. The substituted cyclic imides coumarins and atacoumarins confer significant antimicrobial and antifungal activities and pthalimide proven α-amylase enzymes inhibitory actions [14]. It has been observed that certain aromatic derivatives of succinimide enhance the growth of root of germinating seeds [15]. The different substituted six membered glutarimide derivatives are hydrophobic in nature which exhibits remarkable antibacterial and antifungal efficacy [16]. The anti-proliferative activity of NCI-DIP glutarimide derivatives and 3D QSAR study gives useful guidelines to design and synthesis of novel compounds. They can express significant potency towards differentiated human cells [17]. In this regard different substituted glutarimides were prepared from cyclic anhydrides [18]

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“…Cyclic imides have great importance because their various compounds have a wide range of biological activities, [26,27].…”

Section: -Introductionmentioning

confidence: 99%

Synthesis, Characterization and EPR Study of Some Transition Metal Complexes with N-O Donor Lewis Base of Isonozide.

Hamed

Jabbar

2018

ANJS

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A series of new complexes of the type [Cu(L) 2 ]Cl 2 (1) , [Ni(L)where L is N-(phthalimidyl) isonicotinamide have been synthesized and characterized by magnetic moment, molar conductivity UV, and (FT-IR) and some of them were characterized by EPR spectroscopy. Ligand was characterized by FT-IR, 1 HNMR and 13 CNMR spectroscopy. The spectroscopic data indicated that the isonazide ligand act as bidentate N,O donors and the complexes (2-5) are paramagnetic and the complex(6) diamagnetic. The optimization of their structures indicated that the geometry of complex (1) is square planar and tetrahedral for complex (2) and octahedral for complexes (3-5).

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CoMFA and CoMSIA 3D QSAR Models for a Series of Cyclic Imides with Analgesic Activity

Cited by 9 publications

References 10 publications

Synthesis and Characterization of New Bis-Schiff Bases Linked to Various Imide Cycles

Synthesis and Characterization of New Bis-Schiff Bases Linked to Various Imide Cycles

PGR Evaluation of Novel Synthesized Five and Six Membered Cyclic Imides

Synthesis, Characterization and EPR Study of Some Transition Metal Complexes with N-O Donor Lewis Base of Isonozide.

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