This article reviews research work on set of experience knowledge structure (SOEKS)-decisional DNA (DDNA) done in the past, ongoing, and planned for the future. Firstly, the concept of the knowledge representation technique of SOEKS-DDNA is discussed, and then an attempt is made to organize the past research related with it in chronological order. This work focuses on the review on SOEKS-DDNA, its application in different domains, the various implementation platforms, as well as its benefits and its limitations. The second part of this article provides an idea of the SOEKS-DDNA-related research endeavors currently carried out by us and the last part is a sneak peek into our planned future work.KEYWORDS decisional DNA (DDNA), industrial and manufacturing design, set of experience knowledge set (SOEKS), virtual engineering object BACKGROUND Knowledge and experience are the most valuable assets in any sphere of life. They let us know about the mistakes and successes and reduce time and costs for doing any particular task. Many knowledge-based techniques have been used in past that aim to organize past, present, and future information. Some of the important objectives of these techniques are sharing the information, forecasting, and generating new knowledge.Knowledge-based techniques used in the past have had a fair bit of success but they have their limitations also. Most of the current knowledge systems are designed for a specific domain. The applicability of these systems significantly reduces in any other SOEKS and DDNA 201 area. This makes them less flexible and less versatile. They do not have any standard knowledge representation. Most systems lack the capability for information sharing and exchange (Danilowicz and Nguyen 1988;Qiu et al. 2008;Duong et al. 2010).Another important limitation of current knowledge-based techniques is they do not take into consideration formal experience.In recent times, set of experience knowledge set (SOEKS) and decisional DNA (DDNA), novel and smart knowledge representation techniques, have emerged as strong general purpose solutions to the above-mentioned problems. They are a combination of organized information obtained from formal decision events. SOEKS has been successfully implemented in a variety of domains since its inception. The motivation behind this work is to investigate the SOEKS-related research and present a clear picture about SOEKS.This article includes three parts. The first part discusses the fundamentals of SOEKS and DDNA and reviews different domains and platforms on which SOEKS and DDNA are already been applied. The main aspects considered during the review are how SOEKS is used and the benefits and limitations of using it. The second part presents the concepts of virtual engineering objects (VEOs) and a smart experiencebased data analysis system (SEDAS); these are the current SOEKS-related research areas. The last part of the article, as a future work, proposes a framework to represent the entire design life cycle of an engineering artefact utilizing ...