Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey

Izzo, Raffaele; Trimarco, Valentina; Mone, Pasquale; Aloè, Teresita; Marzani, Massimo Capra; Diana, Antonio; Fazio, Giovanni; Mallardo, Mario; Maniscalco, Mauro; Marazzi, Giuseppe; Messina, Nunzia; Mininni, Simone; Mussi, Chiara; Pelaia, Girolamo; Pennisi, Alfio; Santus, Pierachille; Scarpelli, Francesco; Tursi, Francesco; Zanforlin, Alessandro; Santulli, Gaetano; Trimarcö, Bruno

doi:10.1016/j.phrs.2022.106360

Cited by 60 publications

(55 citation statements)

References 125 publications

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“…However, we respectfully believe that these considerations are not pertinent to our study. Indeed, we designed the LINCOLN (L-Arginine and Vitamin C improves Long-COVID) survey to determine whether a supplementation combining L-Arginine (to improve endothelial function) and Vitamin C (to reduce oxidation) could have favorable effects in patients with Long-COVID [3] . Thus, in our study we did not assess the risk of developing Long-COVID; in fact, as clearly specified in our article, all the enrolled patients had Long-COVID when the survey was administered.…”

mentioning

confidence: 99%

Targeting endothelial dysfunction and oxidative stress in Long-COVID

Trimarco

Izzo

Mone

et al. 2022

Pharmacological Research

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confidence: 99%

Targeting endothelial dysfunction and oxidative stress in Long-COVID

Trimarco

Izzo

Mone

et al. 2022

Pharmacological Research

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“…A clinical trial discovered that oral L-arginine supplementation to standard therapy significantly shorten hospitalization of patients with severe COVID-19 [ 138 ]. Similarly, another group also indicated that combination of L-arginine and vitamin C shows beneficial effects on long-COVID symptoms [ 139 ]. Moreover, L-arginine might attenuate SARS-CoV-2 infection through other mechanisms, such as reducing binding of SARS-CoV-2 to ACE2, inhibiting transmembrane protease serine-type 2, and suppressing SARS-CoV-2 replication [ 133 ].…”

Section: Arginase Contributes To Cvds Developmentmentioning

confidence: 99%

Arginase: shedding light on the mechanisms and opportunities in cardiovascular diseases

Wang

Ren

et al. 2022

Cell Death Discov.

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Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform significant roles in the regulation of cellular functions in cardiovascular system, such as senescence, apoptosis, proliferation, inflammation, and autophagy, via a variety of mechanisms, including regulating L-arginine metabolism and activating multiple signal pathways. Furthermore, abnormal arginase activity contributes to the initiation and progression of a variety of CVDs. Therefore, targeting arginase may be a novel and promising approach for CVDs treatment. In this review, we give a comprehensive overview of the physiological and biological roles of arginase in a variety of CVDs, revealing the underlying mechanisms of arginase mediating vascular and cardiac function, as well as shedding light on the novel and promising therapeutic approaches for CVDs therapy in individuals.

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“…We read with great interest the article from Izzo R. et al [1] . Pandemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have resulted tens of thousands of survivors suffering from long COVID.…”

Section: Dear Editormentioning

confidence: 99%