Targeting endothelial dysfunction and oxidative stress in Long-COVID

Endothelial dysfunction in long-COVID: New insights from the nationwide multicenter LINCOLN Study

“…Of course, we concur on the fact that several factors, including vaccination, virus strains, lifestyle, and body mass index, can influence the risk of developing long-COVID [1] , [2] ; however, these points are not pertinent to our study, since, as we previously clarified [3] , we did not investigate the risk of long-COVID: in fact, all patients who received the LINCOLN ( L -Arginine and V i tami n C impr o ve L o n g-COVID) survey had long-COVID when the questionnaire was administered [4] . Moreover, in Italy, where the study was conducted, >90% of the population has received at least two doses of COVID-19 vaccine.…”

Cardiovascular and haematological pathology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): A role for viruses

“…Implications of endothelial damage have long ago been proposed as a component of ME/CFS pathology that drives symptom manifestation [ 170 ], but is only now starting to receive due attention. The idea of endothelial dysfunction driving ME/CFS seems more plausible after acknowledging such pathology in Long COVID [ 58 , 198 , 210 , [221] , [222] , [223] , 226 , 228 ]; not to mention the evidence of endothelial dysfunction in ME/CFS [ 24 , 45 , 166 , 209 , 210 , 229 , 233 , 236 , 335 ]. Further exploration of the vasculature, cardiac functioning, and coagulation system in ME/CFS is therefore warranted.…”

“…Reduced tissue perfusion and oxygenation at the capillary level, resulting from coagulopathy and endotheliopathy [ 192 , 225 ], is one of the proposed mechanisms for symptom manifestation in Long COVID [ 59 , 198 , 226 ]. Targeting endotheliopathy in Long COVID has shown benefit in some cases [ 224 , 227 , 228 ], and is therefore receiving further exploration. This highlights the question of whether or not endothelial dysfunction is involved in ME/CFS pathology and symptom manifestation.…”

Beneficial effects of L-Arginine in patients hospitalized for COVID-19: New insights from a randomized clinical trial

“…We and others have demonstrated that endothelial dysfunction contributes to coronavirus disease (COVID-19)-associated acute respiratory distress syndrome [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] .…”