Combining Functional Studies with Intraoperative MRI in Glioma Surgery

Krivosheya, Daria; Prabhu, Sujit S.

doi:10.1016/j.nec.2017.05.004

Cited by 9 publications

(7 citation statements)

References 74 publications

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“…The degrees of enhancement and edema of glioma have correlations with the neovascular formation and degree of damage to blood-brain barrier in the tumor (20). T2WI is applied to assess the severity of peritumoral diseases.…”

Section: Discussionmentioning

confidence: 99%

MMP-2 expression and correlation with pathology and MRI of glioma

Zhang

Wang

et al. 2018

Oncol Lett

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The expression of matrix metalloproteinase-2 (MMP-2) in brain glioma and its correlation with patients' clinicopathological characteristics and magnetic resonance imaging (MRI) features were investigated. A total of 104 patients with brain glioma admitted and treated in the First Affiliated Hospital of Anhui Medical University from June 2010 to September 2014 were randomly enrolled. MRI examination was performed before operation. Immunohistochemistry (IHC) was used to detect the expression levels of MMP-2 in brain glioma tissues and paired normal brain tissues after operation and to analyze the associations of MMP-2 expression with the clinicopathological characteristics of brain glioma and survival time of patients. The relationship between MMP-2 expression and preoperative MRI features of glioma was analyzed. The positive rate of MMP-2 expression in brain glioma was 73.08% (76/104), while that in paired normal brain tissues was only 12.5% (13/104), obviously lower than that in brain glioma tissues (P<0.05). The MMP-2 expression in the body of glioma was not related to the patients' sex, age, tumor location and pathological type (P>0.05), but there was a significant correlation with the tumor diameter and pathological grade of the patients (P<0.05). Analysis by Cox model suggested that tumor diameter, pathological grade and MMP-2 were independent prognostic factors for glioma (P<0.05). The overall survival (OS) of patients in the positive MMP-2 expression group was 16.4 months, while the OS in the negative MMP-2 expression group was 20.16 months, and the difference between the two groups was statistically significant (P<0.05). The positive expression of MMP-2 in glioma was closely related to the uniformity of MRI signal for tumor, tumor diameter, severity of peritumoral edema, degree of enhancement and pathological grade of tumor (P<0.05). MMP-2 is highly expressed in brain glioma, and it is a negative factor for prognosis. Therefore, the MRI manifestations of glioma can reflect to some extent the intensity of MMP-2 expression.

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Section: Discussionmentioning

confidence: 99%

MMP-2 expression and correlation with pathology and MRI of glioma

Zhang

Wang

et al. 2018

Oncol Lett

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“…Beyond research purposes, recent advances in DTI resulted in an improved investigation of WMT for surgical planning ( 29 , 30 ). Moreover, preoperative tractography data were incorporated into neuronavigational systems to better define surgical approach and limits of resection into the OR ( 31 , 32 ). However, even though these technological developments played a major role in basic research to explore the connectome ( 3 , 8 ), and started to bring the gap between neuroscience and clinical applications, the link across both worlds is still weak and superficial.…”

Section: How To Integrate a Better Understanding Of The Cerebral Connectome Into Neurosurgical Practice?mentioning

confidence: 99%

Neural Connectivity: How to Reinforce the Bidirectional Synapse Between Basic Neuroscience and Routine Neurosurgical Practice?

Duffau

2021

Front. Neurol.

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“…In order to localize functional brain areas, both preoperative (functional neuroimaging, tractography, neuronavigation) and intraoperative techniques have been described. 5,23,38 Previously published studies have demonstrated the value of cortical and subcortical mapping for decreasing postoperative deficits while improving the extent of resection and overall survival in low-and high-grade gliomas. 18,20,34,[46][47][48]50,51 Eventually, a meta-analysis published in 2012 examining the usefulness of intraoperative mapping showed that this technique is associated with a reduction in late (more than 3 months after surgery) postoperative deficits in adult patients with supratentorial infiltrative gliomas, compared to patients in whom brain mapping was not used during surgery; this method assumed a transient increase in temporary deficits within 3 months of surgery.…”

Section: Impact Of Awake Craniotomy On a Patient's Survival And Neuro...mentioning

confidence: 99%

Outpatient neurosurgery in neuro-oncology

Marigil¹,

Bernstein²

2018

Neurosurgical Focus

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Technological breakthroughs along with modern application of awake craniotomy and new neuroanesthesia protocols have led to a progressive development in outpatient brain tumor surgery and improved surgical outcomes. As a result, outpatient neurosurgery has become a standard of care at the authors’ center due to its clinical benefits and impact on patient recovery and overall satisfaction. On the other hand, the financial savings derived from its application is also another favorable factor exerting influence on patients, health care systems, and society.Although validated several years ago and with recent data supporting its application, outpatient brain tumor surgery has not gained the traction that it deserves, based on scientific skepticism and perceived potential for medicolegal issues. The goal of this review, based on the available literature and the senior author’s experience in outpatient brain tumor surgery, was to evaluate the most important aspects regarding indications, clinical outcomes, economic burden, and patient perceptions.

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Combining Functional Studies with Intraoperative MRI in Glioma Surgery

Cited by 9 publications

References 74 publications

MMP-2 expression and correlation with pathology and MRI of glioma

MMP-2 expression and correlation with pathology and MRI of glioma

Neural Connectivity: How to Reinforce the Bidirectional Synapse Between Basic Neuroscience and Routine Neurosurgical Practice?

Outpatient neurosurgery in neuro-oncology

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