Neural Connectivity: How to Reinforce the Bidirectional Synapse Between Basic Neuroscience and Routine Neurosurgical Practice?

Duffau, Hugues

doi:10.3389/fneur.2021.705135

Front. Neurol.

2021

DOI: 10.3389/fneur.2021.705135

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Neural Connectivity: How to Reinforce the Bidirectional Synapse Between Basic Neuroscience and Routine Neurosurgical Practice?

Hugues Duffau

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Cited by 3 publications

References 69 publications

(89 reference statements)

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Vers un modèle en méta-réseau du fonctionnement cérébral : contribution de la chirurgie éveillée des gliomes de bas grade et implications thérapeutiques

Duffau

2024

Bulletin de l'Académie Nationale de Médecine

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Vers un modèle en méta-réseau du fonctionnement cérébral : contribution de la chirurgie éveillée des gliomes de bas grade et implications thérapeutiques

Duffau

2024

Bulletin de l'Académie Nationale de Médecine

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Tumor location and neurocognitive function—Unravelling the association and identifying relevant anatomical substrates in intra-axial brain tumors

Shah,

Bhartia,

Biswas

et al. 2024

Neuro-Oncology Advances

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Background Neurocognitive function is a key outcome indicator of therapy in brain tumors. Understanding the underlying anatomical substrates involved in domain function and the pathophysiological basis of dysfunction can help ameliorate the effects of therapy and tailor directed rehabilitative strategies. Methods 100 adult diffuse gliomas were co-registered onto a common demographic-specific brain template to create Tumor localization maps (TLMs). Voxel-based lesion symptom (VLSM) technique was used to assign an association between individual voxels and neuropsychological dysfunction in various domains (attention and executive function (A & EF), language, memory, visuospatial/ constructive abilities, and visuomotor speed). The probability maps thus generated were further co-registered to cortical and subcortical atlases. A permutation-based statistical testing method was used to evaluate the statistically and clinically significant anatomical parcels associated with domain dysfunction and to create heat maps. Results Neurocognition was affected in a high proportion of subjects (93%), with A & EF and memory being the most affected domains. Left-sided networks were implicated in patients with A & EF, memory, and language deficits with the perisylvian white matter tracts being the most common across domains. Visuospatial dysfunction was associated with lesions involving the right perisylvian cortical regions, whereas deficits in visuomotor speed were associated with lesions involving primary visual and motor output pathways. Conclusions Significant baseline neurocognitive deficits are prevalent in gliomas. These are multi-domain and the perisylvian network especially on the left side seems to be very important, being implicated in dysfunction of many domains.

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Introducing the concept of brain metaplasticity in glioma: how to reorient the pattern of neural reconfiguration to optimize the therapeutic strategy

Duffau

2022

Journal of Neurosurgery

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Neural Connectivity: How to Reinforce the Bidirectional Synapse Between Basic Neuroscience and Routine Neurosurgical Practice?

Cited by 3 publications

References 69 publications

Vers un modèle en méta-réseau du fonctionnement cérébral : contribution de la chirurgie éveillée des gliomes de bas grade et implications thérapeutiques

Vers un modèle en méta-réseau du fonctionnement cérébral : contribution de la chirurgie éveillée des gliomes de bas grade et implications thérapeutiques

Tumor location and neurocognitive function—Unravelling the association and identifying relevant anatomical substrates in intra-axial brain tumors

Introducing the concept of brain metaplasticity in glioma: how to reorient the pattern of neural reconfiguration to optimize the therapeutic strategy

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