Combining clonal response and genetic response in dairy cattle improvement

Teepker, G.; Smith, C.

doi:10.1017/s0003356100032281

Cited by 12 publications

(9 citation statements)

References 4 publications

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“…The latter value was considered to be able to compare results with Teepker and Smith (1989). Milk efficiency was assumed to have a heritability (h 2 ) of 0-10, 0-25 or 0-40 and was only measurable in females.…”

Section: Selectionmentioning

confidence: 99%

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Genetic and clonal responses in closed dairy cattle nucleus schemes

Boer¹,

Arendonk²

1991

Anim. Sci.

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The additive genetic response per generation and the genetic superiority of female genotype(s) selected for commercial cloning (clonal response) were maximized for a closed adult nucleus scheme, with 256 or 1024 test places, by varying the mating design (number of clones, full-sibs and half-sibs). Responses were corrected for effects of finite sample size and correlated index values on the selection intensity, and variance reduction due to selection. Additive genetic responses, which varied from 0-153 to 0-514 phenotypic standard deviations per generation, were 0-68 to 0-89 of corresponding uncorrected predictions. Reductions were largest when the intensity and accuracy of male selection were high. Clonal responses varied from 0-460 to 2-506 phenotypic standard deviations, increasing with the intra-clone correlation, the intensity of clonal selection and the test capacity. Reductions in clonal responses, which varied from proportionally 0-04 to 0-27, were smallest when dominance variance was high. Increasing the test capacity resulted in a proportionally 0-21 to 1-55 increase in genetic responses, while proportional increases in clonal responses varied from 0-09 to 0-36. With selection of only one male per full-sib family, designs which maximized genetic and clonal responses were different in all cases. Differences were largest when the heritability and the intra-clone correlation were low and the intensity of clonal selection was high. Without the restriction on male selection, optimal mating designs were different, unless dominance variance and intensity of clonal selection were both low.

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Section: Selectionmentioning

confidence: 99%

“…Several studies have found no increase in genetic progress when cloning was used to increase the accuracy of selection (Teepker and Smith, 1989;Woolliams, 1989a). The nucleus will be responsible for the continuous genetic improvement of the breeding stock and for the production of female genotypes eligible for commercial cloning.…”

Section: Introductionmentioning

confidence: 99%

Genetic and clonal responses in closed dairy cattle nucleus schemes

Boer¹,

Arendonk²

1991

Anim. Sci.

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“…The complexity of current algorithms for predicting F values under selection (Wray and Thompson, 1990and Verrier et al, 1990, 1991 (Dempfle, 1990;Senou, 1990;Toro and Perez-Enciso, 1990;Verrier et al, 1991 (Teepker and Smith, 1989;Woolliams, 1980;De Boer and Van Arendonk, 1991 The first derivatives of u and v with respect to m l , m 2 , m 3 , m 4 , m!, f l , f 2 , f 3 , f 4 , f 5 are very simple:…”

Section: Methodsmentioning

confidence: 99%

“…Schemes using the full reproductive capacity of a given genotype allowed by cloning were found to be superior (+5 to +10% ) when the number of live replicates per cloned heifer was moderate (3-5). They were even more superior for higher number of replicates (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) (Van Vleck, 1981;Nicholas and Smith, 1983;Smith, 1989;Teepker and Smith, 1989;Woolliams, 1989;De Boer and Van Arendonk, 1991 (Colleau, 1991) …”

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confidence: 99%

Combining use of embryo sexing and cloning within mixed MOETs for selection on dairy cattle

Colleau¹

1992

Genet. Sel. Evol.

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“…Several studies have focused on the use of clones in dairy cattle production, because of their potential use for rapidly increasing the average genetic level of milking cows (Van Vleck, 1981;Nicholas and Smith, 1983;Woolliams, 1989;Teepker and Smith, 1989;de Boer and van Arendonk, 1991;Colleau, 1992;de Boer, Meuwissen and van Arendonk, 1994;). To illustrate the approach we will consider the use of clones in dairy cattle breeding.…”

Section: Introductionmentioning

confidence: 99%

An ethical evaluation of animal biotechnology: the case of using clones in dairy cattle breeding

1995

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77ns paper presents an approach for ethical evaluation of biotechnology, which is illustrated by cloning in dairy cattle breeding. The approach for ethical decision-making that was followed, the so-called network model, started with determining fundamental moral principles that together constitute a framework for the detection of ethical issues in a given situation. In terms of human ethics, four fundamental principles have been defined: beneficence, non-maleficence, justice and autonomy. In the context of animal biotechnology, the same four fundamental moral principles as in humans are considered, except that autonomy is replaced by respect for the integrity of the animal. Based on a Dutch advisory committee concerning animal biotechnology, two additional principles were considered: irreversibility and veriflability. For each individual case, moral decision-making means balancing of moral intuitions, moral principles and morally relevant facts. The final outcome on moral acceptability of an action, therefore, will differ among people. The latter is demonstrated using three types of people (the ruler, the steward and the partner/participant). For each type of person, the fundamental attitude toward animals and nature is defined and a possible decision on the application of cloning in dairy cattle breeding is given. The authors' opinion, however, is that the benefits of cloning are relatively small, especially in the long term, whereas the moral drawbacks of cloning are considerable. The authors conclude that other ways of furthering animal husbandry should have priority.

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Combining clonal response and genetic response in dairy cattle improvement

Cited by 12 publications

References 4 publications

Genetic and clonal responses in closed dairy cattle nucleus schemes

Genetic and clonal responses in closed dairy cattle nucleus schemes

Combining use of embryo sexing and cloning within mixed MOETs for selection on dairy cattle

An ethical evaluation of animal biotechnology: the case of using clones in dairy cattle breeding

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