Combining a flow reactor with spray dryer to allow the preparation of food-grade quality sodium 2-polyhydroxyalkyl-1,3-thiazolidine-4-carboxylates with a low environmental impact

Abstract

The 1,3-thiazolidine-4-carboxylic acid (TCA) and 2-substituted 1,3-thiazolidine-4-carboxylic acids (2S-TCAs) are used as additive prodrugs of cysteine and glutathione in agronomy and in the food and pharmaceutical industries.

Synthesis, Antibacterial Activity and DFT Calculations of Some Thiazolidine-4-Carboxylic acid Derivatives and Their Complexes with Cu(II), Fe(II) and VO(II)

“…In the pharmaceutical industry, thiazolidines and their derivatives find applications as potent enzyme [6], receptor antagonists and important building blocks for medicines [7,8]. Therefore, thiazolidine-4-carboxylic acid allows restoring "contact inhibition" pertaining to tumour cells and its interaction with metal ions is regarded to be of key significance [9,10].…”

“…Therefore, thiazolidine-4-carboxylic acid allows restoring "contact inhibition" pertaining to tumour cells and its interaction with metal ions is regarded to be of key significance [9,10]. The derivatives pertaining to 2-substituted thiazolidine -4-carboxylic acids find application as key intermediates in peptide synthesis [11], as well as preparation of antiviral [2], microencapsulated liposomal and immunostimulating biological drugs [7,12].…”