Combined Vaccination by Measles and Hepatitis B Vaccines: A New Cause of Gianotti-Crosti Syndrome

Abstract

An 11-month-old boy presented with Gianotti-Crosti syndrome. He had received measles and a third dose of hepatitis B vaccines 2 weeks before the onset of the eruption. There were no clinical symptoms of any viral infection at the presentation. Serological tests for common viral infections were negative. The combination of measles and hepatitis B vaccines was likely the relevant factor in the etiology.

Gianotti–Crosti syndrome in a child following hepatitis B virus vaccination

“…In our case, we believe that HBV vaccination may have played a similar role in the development of GCS syndrome after applying different types of combined 11 or single vaccines 13 …”

A case report of Gianotti‐Crosti post vaccination with MMR and dTaP

“…The link to viral infection may explain why there is a seasonal variation for the diagnosis of Gianotti‐Crosti, occurring more commonly in the springtime 2 . Gianotti‐Crosti syndrome has also been linked to childhood immunizations such as hepatitis A and B, MMR, oral polio, influenza, and Japanese encephalitis vaccine 3 . A combination of receiving vaccinations with simultaneous evidence of viral infection may also heighten susceptibility to Gianotti‐Crosti syndrome.…”

“…2 Gianotti-Crosti syndrome has also been linked to childhood immunizations such as hepatitis 609 A and B, MMR, oral polio, influenza, and Japanese encephalitis vaccine. 3 A combination of receiving vaccinations with simultaneous evidence of viral infection may also heighten susceptibility to Gianotti-Crosti syndrome.…”

Gianotti-Crosti Syndrome in Two Adult Patients

“…16 Gianotti-Crosti syndrome has also been reported following vaccination for hepatitis B; influenza; polio; measles, mumps, and rubella; and Japanese encephalitis. 5,18,[22][23][24][25] The clinical appearance of skin lesions in both children and adults is relatively nonspecific for the causative virus, and the phenotypic variations are likely secondary to the age and immune status of the patient. 16 The term Gianotti-Crosti syndrome encompasses all benign and self-limited acral skin eruptions with a papular or papulovesicular appearance secondary to a viral infection and is self-resolving within weeks.…”