Combined Use of Ultrasonography and Contrast Enhanced Computed Tomography to Evaluate Acute Necrotizing Pancreatitis in Two Dogs

Jaeger, Jordan Q.; Mattoon, John S.; Bateman, Shane; Morandi, Federica

doi:10.1111/j.1740-8261.2003.tb01453.x

Cited by 42 publications

(45 citation statements)

References 10 publications

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“…17 The presence of hyperechogenicity surrounding the pancreas on ultrasound reflects peri-pancreatic fat necrosis, and necrosis is considered the most significant indicator of severe disease in human beings. 2,6 Serum cPE-1 and canine pancreatic-specific lipase appear to have similar sensitivities in the diagnosis of severe acute pancreatitis (78% and 82%, respectively). 17 The use of blood tests alone to diagnose pancreatitis should not be relied upon in clinical practice, and combination with abdominal ultrasound may prove to have the highest sensitivity and specificity for diagnosis of severe acute pancreatitis in dogs.…”

Section: Discussionmentioning

confidence: 96%

Specificity and sensitivity of serum canine pancreatic elastase-1 concentration in the diagnosis of pancreatitis

2011

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Abstract. The aim of the current study was to determine the sensitivity and specificity of serum canine pancreatic elastase-1 (cPE-1) for the diagnosis of pancreatitis in dogs. The study was prospective, assessing dogs presenting with clinical signs similar to pancreatitis. Sixty-one dogs were recruited (49 with pancreatic disease and 12 with non-pancreatic disease). There was no significant difference in serum cPE-1 between dogs with pancreatic disease and non-pancreatic disease. However, there was a significant difference in serum cPE-1 between severe acute pancreatitis and non-pancreatic disease. A cut-off value for serum cPE-1 > 17.24 ng/ml resulted in sensitivity of 61.4% and specificity of 91.7% for diagnosis of all types of pancreatic disease. The sensitivity rose to 65.85% and 78.26% for the diagnosis of all types of acute pancreatitis and severe acute pancreatitis, respectively. Serum cPE-1 is more sensitive at diagnosing severe acute pancreatitis than chronic or mild acute pancreatitis, and has a high positive likelihood ratio. Dogs with chronic pancreatitis tended to have lower serum cPE-1 concentration, suggesting decreased exocrine function.

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Section: Discussionmentioning

confidence: 96%

Specificity and sensitivity of serum canine pancreatic elastase-1 concentration in the diagnosis of pancreatitis

2011

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“…But even in animals in which an increase in PLI suggests pancreatic inflammation, the source of that inflammation remains unidentified and could be acute nonsuppurative or chronic lympoplasmacytic pancreatitis, pancreatic tissue necrosis, culture‐confirmed infection, pancreatic pseudocyst or abscess, neoplasia, or pancreatitis secondary to another disease process such as inflammatory bowel disease or bile duct obstruction. Noninvasive imaging studies such as radiograph, ultrasonography, or computed tomography have variable degrees of sensitivity and specificity, are often dependent on the experience of the person performing the study, and cannot provide a tissue diagnosis 5–10 . The gold standard for the diagnosis of exocrine pancreatic disease in animals remains histopathology.…”

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confidence: 99%

Laparoscopic Diagnosis of Pancreatic Disease in Dogs and Cats

Webb

Trott

2008

Veterinary Internal Medicne

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Background: Histopathology is the gold standard for the diagnosis of pancreatic disease. Laparoscopy offers a minimally invasive route by which to obtain pancreatic biopsies. Hypothesis: Laparoscopy is a safe and effective technique for evaluating the pancreas in small animal patients. Animals: Medical records of 18 dogs and 13 cats examined between 1999 and 2007 that underwent laparoscopy during which observation or biopsy of the pancreas was recorded. Methods: The database for the Laparoscopy Laboratory at Colorado State University was searched for records that contained “pancreatitis,”“pancreas,” or “pancreatic.” The presenting complaints, imaging studies, and histopathologic findings of animals were recorded. All hospital admissions were searched for animals with the same presenting complaints and of those it was determined which animals had exploratory surgery and their pancreas biopsied. Results: Thirteen cats and 18 dogs underwent laparoscopy for presumptive pancreatic disease or had the appearance of the pancreas described, pancreatic biopsies obtained, or both. In 14 animals a laparoscopic biopsy of the pancreas resulted in a histopathologic diagnosis when the sonographic findings or the gross assessment failed to do so. In 35% of the animals a biopsy of the pancreas was not obtained despite findings consistent with pancreatic disease. Those animals examined for vomiting or anorexia were significantly more likely to have a biopsy of the pancreas obtained through laparoscopy versus surgery (P < .0001). Conclusions and Clinical Importance: Laparoscopy and pancreatic biopsy is useful for evaluation of pancreatic disease.

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“…Small animals can be affected by pancreatitis just like humans, causing marked enlargement and a hypoechoic appearance in the acute stage. [26][27][28] Imaging the gastrointestinal tract is an important part of veterinary medicine that not all human sonographers are proficient. The gastrointestinal tract consists of the stomach, duodenum, jejunum, ileum, cecum, and colon.…”

Section: Urologicmentioning

confidence: 99%