Combined use of autologous bone marrow-derived stem cells and platelet-rich plasma for ovarian rejuvenation in poor responders

Tandulwadkar, Sunita; Karthick, M Selva

doi:10.4103/jhrs.jhrs_130_19

Cited by 9 publications

(5 citation statements)

References 31 publications

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“…Some studies have observed even further improvement after combining the autologous bone marrow-derived stem cells and PRP for ovarian rejuvenation. 25…”

Section: Discussionmentioning

confidence: 99%

Efficacy of autologous platelet rich plasma for ovarian rejuvenation in infertile women having poor ovarian reserve

Banu

Mostafa

Jahan

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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Background: Poor ovarian reserve (POR) is a condition in which the ovary loses its normal reproductive potential and compromising fertility. Normal function of the ovaries and adequate good quality follicles are responsible for the reproductive process of a woman. Various treatment methods exist for POR, but the present study was conducted to observe the effectiveness of platelet rich plasma infusion through measurement of AMH and AFC values and pregnancy outcomes.Methods: This prospective observational study was done in the department of reproductive endocrinology and infertility from July 2019 to June 2022. A total of 60 patients with poor ovarian reserve were recruited maintaining inclusion and exclusion criteria.Results: Mean age of the participants was 36.4 years, with 78.32% of the participants being housewives and 21.68% being service workers. 65.38% had education below SSC levels. 72.46% had primary infertility while 27.54% had secondary infertility. At first cycle, compared to baseline counts, mean±SD AMH had increased by 0.04±0.15 ng/dl, and mean±SD AFC had increased by 1.34±1.89 in number. During second cycle post-PRP, the mean difference of AMH and AFC was 0.18±0.21 ng/dl and 2.17±1.71 in a positive manner. By final follow-up, pregnancy rate was 20% among patients.Conclusions: The study observed significant improvement in AMH and AFC values following PRP infusion. The improvement of both values was gradual, and increase of AMH values were observed up to second post-PRP menstrual cycle, while AFC increased till third cycle post-PRP. Among 60 patient twelve (12) had pregnancy (20%).

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“…Some studies have observed even further improvement after combining the autologous bone marrow-derived stem cells and PRP for ovarian rejuvenation. 25…”

Section: Discussionmentioning

confidence: 99%

Efficacy of autologous platelet rich plasma for ovarian rejuvenation in infertile women having poor ovarian reserve

Banu

Mostafa

Jahan

et al. 2022

Int J Reprod Contracept Obstet Gynecol

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“…In 2020, a pilot study by Tandulwadkar and Karthick. [ 10 ] assessed the synergistic effect of ABMDSCs with PRP for ovarian rejuvenation. They observed that autologous PRP attracts stem cells to the site of injury and boosts their response.…”

Section: Discussionmentioning

confidence: 99%

Successful application of combined autologous bone marrow-derived stem cells and platelet-rich plasma in a case of severe asherman syndrome and subsequent in vitro fertilization conception

2021

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The application of stem cells in infertility is still experimental. Thin endometrium is an important cause of cancelled or less successful frozen embryo transfer cycles. Clinically, numerous strategies have been adopted to promote endometrial regeneration including extended oestrogen administration, low-dose aspirin, pentoxifylline, tocopherol, vaginal sildenafil citrate and intrauterine perfusion with granulocyte colony-stimulating factor. However, even with the use of these therapies, the endometrium in some patients still remains unresponsive. Latest research shows that autologous bone marrow-derived stem cells (ABMDSCs) can be used for regeneration of damaged endometrium. We present a case report of patient with thin endometrium who was successfully treated with the combined use of ABMDSCs mixed with platelet-rich plasma, leading to successful in vitro fertilization conceived pregnancy. Patient consent and due ethical clearance were taken before starting the procedure.

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“…Combined application of PVRP and stem cells showed good therapeutic effects in bone healing [ 161 , 268 ], osteoporosis [ 266 ], ovarian rejuvenation [ 269 ], skin wound healing [ 270 ] and more.…”

Section: Use Of Plasma Rich With Platelets and Extracellular Vesicles...mentioning

confidence: 99%

Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

Troha

Vozel

Arko

et al. 2023

IJMS

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The preparation of autologous platelet and extracellular vesicle-rich plasma (PVRP) has been explored in many medical fields with the aim to benefit from its healing potential. In parallel, efforts are being invested to understand the function and dynamics of PVRP that is complex in its composition and interactions. Some clinical evidence reveals beneficial effects of PVRP, while some report that there were no effects. To optimize the preparation methods, functions and mechanisms of PVRP, its constituents should be better understood. With the intention to promote further studies of autologous therapeutic PVRP, we performed a review on some topics regarding PVRP composition, harvesting, assessment and preservation, and also on clinical experience following PVRP application in humans and animals. Besides the acknowledged actions of platelets, leukocytes and different molecules, we focus on extracellular vesicles that were found abundant in PVRP.

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Combined use of autologous bone marrow-derived stem cells and platelet-rich plasma for ovarian rejuvenation in poor responders

Cited by 9 publications

References 31 publications

Efficacy of autologous platelet rich plasma for ovarian rejuvenation in infertile women having poor ovarian reserve

Efficacy of autologous platelet rich plasma for ovarian rejuvenation in infertile women having poor ovarian reserve

Successful application of combined autologous bone marrow-derived stem cells and platelet-rich plasma in a case of severe asherman syndrome and subsequent in vitro fertilization conception

Autologous Platelet and Extracellular Vesicle-Rich Plasma as Therapeutic Fluid: A Review

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