Combined use of a modifier gas generator, analyte protectants and multiple internal standards for effective and robust compensation of matrix effects in gas chromatographic analysis of pesticides

Tsuchiyama, Tomoyuki; Katsuhara, Miki; Sugiura, Jun; Nakajima, Masahiro; Yamamoto, Atsushi

doi:10.1016/j.chroma.2018.12.051

Cited by 13 publications

(4 citation statements)

References 28 publications

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“…Soil is an extremely complex matrix that typically requires a clean-up step prior to injection into the chromatographic system to remove undesired coextracted substances and minimize the matrix effect. These substances can act as interferences and negatively affect the reproducibility and sensitivity of the pesticide quantification, as well as increasing the need for equipment maintenance [67,68]. Therefore, in addition to the recovery assessment, the impact on the instrumental performance must also be considered.…”

Section: The Clean-up Stepmentioning

confidence: 99%

Pesticide-Residue Analysis in Soils by the QuEChERS Method: A Review

2022

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Pesticides are among the most important contaminants worldwide due to their wide use, persistence, and toxicity. Their presence in soils is not only important from an environmental point of view, but also for food safety issues, since such residues can migrate from soils to food. However, soils are extremely complex matrices, which present a challenge to any analytical chemist, since the extraction of a wide range of compounds with diverse physicochemical properties, such as pesticides, at trace levels is not an easy task. In this context, the QuEChERS method (standing for quick, easy, cheap, effective, rugged, and safe) has become one of the most green and sustainable alternatives in this field due to its inherent advantages, such as fast sample preparation, the minimal use of hazardous reagents and solvents, simplicity, and low cost. This review is aimed at providing a critical revision of the most relevant modifications of the QuEChERS method (including the extraction and clean-up steps of the method) for pesticide-residue analysis in soils.

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Section: The Clean-up Stepmentioning

confidence: 99%

Pesticide-Residue Analysis in Soils by the QuEChERS Method: A Review

2022

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“…If the sample treatment proves ineffective in avoiding the matrix effect, it can be compensated for by applying two main strategies: (1) by using matrix-matched calibration curves (i.e., calibration curves of standards prepared in blank matrix extracts), or (2) by using isotopically labeled internal standards (IL-ISs). Both strategies are commonly applied for either LC-MS [25,128] or GC-MS methods [129,130]. It should be noted that although only one or a few IL-ISs are selected for the IL-IS approach, the quantitative performance of multiresidue methods increases when multiple IL-ISs covering different families of pesticides are used [131,132].…”

Section: Matrix Effectmentioning

confidence: 99%

Current Role of Mass Spectrometry in the Determination of Pesticide Residues in Food

Hernández‐Mesa

Moreno‐González

2022

Separations

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The extensive use of pesticides represents a risk to human health. Consequently, legal frameworks have been established to ensure food safety, including control programs for pesticide residues. In this context, the performance of analytical methods acquires special relevance. Such methods are expected to be able to determine the largest number of compounds at trace concentration levels in complex food matrices, which represents a great analytical challenge. Technical advances in mass spectrometry (MS) have led to the development of more efficient analytical methods for the determination of pesticides. This review provides an overview of current analytical strategies applied in pesticide analysis, with a special focus on MS methods. Current targeted MS methods allow the simultaneous determination of hundreds of pesticides, whereas non-targeted MS methods are now applicable to the identification of pesticide metabolites and transformation products. New trends in pesticide analysis are also presented, including approaches for the simultaneous determination of pesticide residues and other food contaminants (i.e., mega-methods), or the recent application of techniques such as ion mobility–mass spectrometry (IM–MS) for this purpose.

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“…Now, it is extensively adopted to extract pesticides from agricultural products [7,8]. However, a limitation associated with this technique is the matrix-induced signal enhancement effect when it is combined with GC-MS/MS to analyze pesticides in agricultural products [9]. When the standard solutions of pesticides prepared in pure solvent were injected to a GC system, these pesticides would decompose or interact with the active sites (mainly silanols and metal ions) in the GC liner or column, which led to the signal loss of pesticides.…”

Section: Introductionmentioning

confidence: 99%

“…In 2003, Anastassiades et al [15] demonstrated the combination of 3-ethoxy-1,2propanediol, gulonolactone, and sorbitol was the best ana-lyte protectant for most pesticides in GC-MS. Later in 2007, shikimic acid was added to the AP combination by the same group [12] to protect base-labile pesticides. However, these APs must be dissolved in polar solvents (i.e., ACN) with some water added to the final extracts due to their high polarities, which limited their application in GC analysis [9,12]. Afterward, natural extracts such as pepper leaf extract [16] and cucumber extract [13] were developed as effective APs for determination of pesticides in agricultural products, even though the matrix effects of lateeluting pyrethroids were still not properly compensated by the APs.…”

Section: Introductionmentioning

confidence: 99%

A modified quick, easy, cheap, effective, rugged, and safe method with hydrophobic natural deep eutectic solvent as extractant and analyte protectant for analyzing pyrethroid residues in tomatoes

et al. 2020

J of Separation Science

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In this work, a novel quick, easy, cheap, effective, rugged, and safe technique with hydrophobic natural deep eutectic solvent as both extractant and analyte protectant was developed and combined with gas chromatography–tandem mass spectrometry to analyze pyrethroid residues in tomatoes. Eight hydrophobic natural deep eutectic solvents were first evaluated as analyte protectants and those with decanoic acid or lactic acid as hydrogen bond donor were demonstrated to be effective in compensating for the matrix effects of pyrethroids in the gas chromatography system. Hence, they were added to solvent standards for correcting the quantitation errors instead of matrix‐matched calibration standards. Then the abilities of these acid‐based deep eutectic solvents to extract pyrethriods from tomatoes were evaluated. Results showed the recoveries of all pyrethroids reached to over 80% with only 5 mL menthol:decanoic acid (1:1) used, and good phase separation was easily achieved without the addition of inorganic salt in the extraction step, indicating hydrophobic natural deep eutectic solvent could be a green substitute for acetonitrile in the quick, easy, cheap, effective, rugged, and safe extraction. Compared with the conventional method, the proposed protocol improved the recoveries, reduced the matrix effects, and simplified the extraction step, demonstrating to be an effective, fast, and green method.

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Combined use of a modifier gas generator, analyte protectants and multiple internal standards for effective and robust compensation of matrix effects in gas chromatographic analysis of pesticides

Cited by 13 publications

References 28 publications

Pesticide-Residue Analysis in Soils by the QuEChERS Method: A Review

Pesticide-Residue Analysis in Soils by the QuEChERS Method: A Review

Current Role of Mass Spectrometry in the Determination of Pesticide Residues in Food

A modified quick, easy, cheap, effective, rugged, and safe method with hydrophobic natural deep eutectic solvent as extractant and analyte protectant for analyzing pyrethroid residues in tomatoes

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