Combined training increases thermogenic fat activity in patients with overweight and type 2 diabetes

Bonfante, Ivan Luiz Padilha; Monfort-Pires, Milena; Duft, Renata Garbellini; Mateus, Keryma Chaves da Silva; Júnior, José Carlos de Lima; Trombeta, Joice Cristina dos Santos; Finardi, Enrico Antonio Rautenberg; Brunelli, Diego Trevisan; Morari, Joseane; Lima, Juliano Silva; Bellotto, Maria Luisa; Araújo, Thiago Matos Ferreira de; Ramos, Celso Darío; Chacon‐Mikahil, Mara Patrícia Traina; Velloso, Lı́cio A.; Cavaglieri, Cláudia Regina

doi:10.1038/s41366-022-01086-3

Cited by 12 publications

(15 citation statements)

References 58 publications

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Section: Anti-inflammatory Adipokinesmentioning

confidence: 78%

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New Discovered Adipokines Associated with the Pathogenesis of Obesity and Type 2 Diabetes

Cheng¹,

Yu²

2022

DMSO

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Obesity is defined as abnormal or excessive accumulation of adipose tissue, closely associated with the increased risk of various comorbidities, especially type 2 diabetes mellitus (T2DM). Adipose tissue is a complex structure responsible for not only fat storage but also releasing adipokines which may play roles in the pathogenesis and could be developed into biomarkers for diagnosis, treatment and prognosis of obesity-related metabolic diseases. This review aims to summarize several adipokines discovered recently that have promising functions in obesity and T2DM. Among them, the levels of FSTL1, WISP1 and Asprosin in subjects with obesity or diabetes are commonly higher than in normal controls, suggesting that they may be pathogenic. Inversely, SFRP5, Metrnl, NRG4 and FAM19A5 may serve as the protective factors.

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Section: Anti-inflammatory Adipokinesmentioning

confidence: 78%

“…69 CT for 16 weeks increased brown adipose tissue (BAT) thermogenic activity as well as serum Metrnl levels. 70 Metformin treatment did not increase the serum Metrnl levels after 12 weeks. 60 Although Metrnl has shown emerging effects in obesity, T2DM and dyslipidemia, there are conflicts in the clinical results.…”

Section: Clinical Studiesmentioning

confidence: 78%

New Discovered Adipokines Associated with the Pathogenesis of Obesity and Type 2 Diabetes

Cheng¹,

Yu²

2022

DMSO

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“…121 In a recent study, exercise upregulates the expression of autophagic markers in the adipose tissue of obese and diabetic patients. 122 However, in another study, autophagy markers were not modulated in skeletal muscle biopsies of type 2 diabetic patients undergoing exercise. 123,124 Further studies should correlate the levels of circulating markers of autophagy with vascular and cardiac function in obese and diabetic individuals undergoing exercise, in addition to muscle cells and PBMCs.…”

Section: Functional and Morphological Effects Vesselmentioning

confidence: 93%

Molecular mechanisms underlying the beneficial effects of exercise and dietary interventions in the prevention of cardiometabolic diseases

Forte

Rodolico

Ameri

et al. 2022

Journal of Cardiovascular Medicine

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Cardiometabolic diseases still represent a major cause of mortality worldwide. In addition to pharmacological approaches, lifestyle interventions can also be adopted for the prevention of these morbid conditions. Lifestyle changes include exercise and dietary restriction protocols, such as calorie restriction and intermittent fasting, which were shown to delay cardiovascular ageing and elicit health-promoting effects in preclinical models of cardiometabolic diseases. Beneficial effects are mediated by the restoration of multiple molecular mechanisms in heart and vessels that are compromised by metabolic stress. Exercise and dietary restriction rescue mitochondrial dysfunction, oxidative stress and inflammation. They also improve autophagy. The result of these effects is a marked improvement of vascular and heart function. In this review, we provide a comprehensive overview of the molecular mechanisms involved in the beneficial effects of exercise and dietary restriction in models of diabetes and obesity. We also discuss clinical studies and gap in animal-to-human translation.

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“…However, exercise training consistently fails to induce browning in humans even though exercise brings other benefits to human’s health ( 47 , 57 , 58 ). Surprisingly, a recent randomized and controlled study found that after combined training, the thermogenic activity of BAT was significantly increased in overweight or T2DM patients, and the expression of genes related to thermogenic profile (TMEM26, EPSTI1) in subcutaneous fat was significantly increased ( 59 ). However, some experimental evidence in rats suggests otherwise.…”

Section: Exercise-induced Browning Of Watmentioning

confidence: 99%

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

et al. 2023

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Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1. Over the last decade, an in-creasing number of studies have found that activating brown adipose tissue and browning of white adipose tissue can protect against obesity and obesity-related metabolic disease. Brown adipose tissue has gradually become an appealing therapeutic target for the prevention and re-versal of obesity. However, some important issues remain unresolved. It is not certain whether increasing brown adipose tissue activity is the cause or effect of body weight loss or what the risks might be for sympathetic nervous system-dependent non-shivering thermogenesis. In this review, we comprehensively summarize approaches to activating brown adipose tissue and/or browning white adipose tissue, such as cold exposure, exercise, and small-molecule treatment. We highlight the functional mechanisms of small-molecule treatment and brown adipose tissue transplantation using batokine, sympathetic nervous system and/or gut microbiome. Finally, we discuss the causality between body weight loss induced by bariatric surgery, exercise, and brown adipose tissue activity.

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Combined training increases thermogenic fat activity in patients with overweight and type 2 diabetes

Cited by 12 publications

References 58 publications

New Discovered Adipokines Associated with the Pathogenesis of Obesity and Type 2 Diabetes

New Discovered Adipokines Associated with the Pathogenesis of Obesity and Type 2 Diabetes

Molecular mechanisms underlying the beneficial effects of exercise and dietary interventions in the prevention of cardiometabolic diseases

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

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