New Discovered Adipokines Associated with the Pathogenesis of Obesity and Type 2 Diabetes

Cheng, Jia-Xue; Yu, Ke

doi:10.2147/dmso.s376163

Cited by 18 publications

(9 citation statements)

References 96 publications

(134 reference statements)

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“…In addition, many novel adipokines have been recently identified, such as follistatin-like 1 (FSTL1), wingless-type inducible signaling pathway protein 1 (WISP1), or Asprosin, among others. Recent evidence suggests they play a role in the development of metabolic diseases [ 236 ], but further studies need to investigate their immunomodulatory properties and impact on psoriasis. The increasing number of discovered adipokines determines the development of an interesting research field.…”

Section: Discussionmentioning

confidence: 99%

The Role of Adipokines in the Pathogenesis of Psoriasis

Kiełbowski

Bakinowska

Ostrowski

et al. 2023

IJMS

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Psoriasis is a chronic and immune-mediated skin condition characterized by pro-inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes, and keratinocytes represent the main cell subtypes involved in the pathogenesis of psoriasis, while the interleukin-23 (IL-23)/IL-17 pathway enhances the disease progression. Human adipose tissue is an endocrine organ, which secretes multiple proteins, known as adipokines, such as adiponectin, leptin, visfatin, or resistin. Current evidence highlights the immunomodulatory roles of adipokines, which may contribute to the progression or suppression of psoriasis. A better understanding of the complexity of psoriasis pathophysiology linked with adipokines could result in developing novel diagnostic or therapeutic strategies. This review aims to present the pathogenesis of psoriasis and the roles of adipokines in this process.

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Section: Discussionmentioning

confidence: 99%

The Role of Adipokines in the Pathogenesis of Psoriasis

Kiełbowski

Bakinowska

Ostrowski

et al. 2023

IJMS

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“…Overexpression of pro-inflammatory adipokines, or a lack of anti-inflammatory adipokines in experiments carried out on rodents are causally associated with the occurrence and development of obesity and T2DM. Pro-inflammatory adipokines increase while anti-inflammatory adipokines decrease in both obese rodents and humans, which is associated with corresponding metabolic indicators of obesity and T2DM [ 133 ].…”

Section: Pathogenesismentioning

confidence: 99%

Non-Alcoholic Fatty Liver Disease or Type 2 Diabetes Mellitus—The Chicken or the Egg Dilemma

2023

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In clinical practice, we often deal with patients who suffer from non-alcoholic fatty liver disease (NAFLD) concurrent with type 2 diabetes mellitus (T2DM). The etiopathogenesis of NAFLD is mainly connected with insulin resistance (IR) and obesity. Similarly, the latter patients are in the process of developing T2DM. However, the mechanisms of NAFLD and T2DM coexistence have not been fully elucidated. Considering that both diseases and their complications are of epidemic proportions and significantly affect the length and quality of life, we aimed to answer which of these diseases appears first and thereby highlight the need for their diagnosis and treatment. To address this question, we present and discuss the epidemiological data, diagnoses, complications and pathomechanisms of these two coexisting metabolic diseases. This question is difficult to answer due to the lack of a uniform procedure for NAFLD diagnosis and the asymptomatic nature of both diseases, especially at their beginning stages. To conclude, most researchers suggest that NAFLD appears as the first disease and starts the sequence of circumstances leading ultimately to the development of T2DM. However, there are also data suggesting that T2DM develops before NAFLD. Despite the fact that we cannot definitively answer this question, it is very important to bring the attention of clinicians and researchers to the coexistence of NAFLD and T2DM in order to prevent their consequences.

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“…In contrast to follistatin, levels of circulating FSTL1 protein were elevated in obese women. FSTL1 also was reported to be associated with insulin resistance and T2D [ 197 ].…”

Section: Polycystic Ovary Syndromementioning

confidence: 99%

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

Schüler-Toprak¹,

Ortmann²,

Buechler³

et al. 2022

Biomedicines

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Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female reproductive tract causing high morbidity as they can significantly affect fertility and quality of life. Adipokines are pleiotropic signaling molecules secreted by white or brown adipose tissues with a central role in energy metabolism. More recently, their involvement in PCOS and endometriosis has been demonstrated. In this review article, we provide an update on the role of adipokines in both diseases and summarize previous findings. We also address the results of multi-omics approaches in adipokine research to examine the role of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes and to identify epigenetic alterations of adipokine genes that might be conferred from mother to child. Finally, we address novel data on the role of brown adipose tissue (BAT), which seems to have notable effects on PCOS. For this review, original research articles on adipokine actions in PCOS and endometriosis are considered, which are listed in the PubMed database.

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New Discovered Adipokines Associated with the Pathogenesis of Obesity and Type 2 Diabetes

Cited by 18 publications

References 96 publications

The Role of Adipokines in the Pathogenesis of Psoriasis

The Role of Adipokines in the Pathogenesis of Psoriasis

Non-Alcoholic Fatty Liver Disease or Type 2 Diabetes Mellitus—The Chicken or the Egg Dilemma

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

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