Combined systemic inflammatory immunity index and prognostic nutritional index scores as a screening marker for sarcopenia in patients with locally advanced gastric cancer

Ding, Pingan; Lv, Jingxia; Sun, Chenyu; Chen, Shuya; Yang, Peigang; Tian, Yuan; Zhou, Qin; Guo, Honghai; Liu, Yang; Zhao, Qun

doi:10.3389/fnut.2022.981533

Cited by 15 publications

(14 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies paid more attention to the role of nutrition in sarcopenia and surgery (35)(36)(37). A prospective study from China showed that the combined systemic inflammatory immunity index and prognostic nutritional index scores as an indicator of nutrition status may predict the incidence of sarcopenia for patients with advanced gastric cancer who underwent radical surgical resection (38). Moreover, a cohort study conducted in Japan reported that the protein intake may affect the skeletal muscle mass of patients who underwent kidney transplantation, and suggested that a protein intake of more than 0.72 g/kg IBW/day may provide the patients with improved skeletal muscle mass (37).…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of research trends in relationship between sarcopenia and surgery

Liu

Song

et al. 2023

Front. Surg.

View full text Add to dashboard Cite

BackgroundThe relationship between sarcopenia and surgery has attracted an increasing number of researchers in recent years. Our study aimed to identify the current research hotspot and status in this field by using bibliometric and visualization analysis.MethodsPublications about the relationship between sarcopenia and surgery that met the inclusion criteria were collected from the Science Citation Index Expanded. The bibliometric and visualized studies were performed using VOSviewer, and R.ResultsA total of 2,261 documents on the relationship between sarcopenia and surgery were included in our study. These articles were written by 13,757 authors from 2,703 institutions in 70 countries and were published in 772 journals. The USA is the most productive and influential country in this field (524 publications and 15,220 citations). The Udice French Research Universities was the most productive institution in this field (57 publications), and the University of Alberta had the largest number of citations. Annuals of Surgical Oncology published the most studies in this field. Shen Xian was the most productive author in this field (number of publications = 19), and Baracos Vickie was the most influential author, whose studies in this field had been cited 2,209 times. The cluster analysis was performed and visualized, and the keywords were classified into 6 clusters: Cluster 1 (body composition and nutrition), Cluster 2 (sarcopenia), Cluster 3 (malnutrition and cachexia), Cluster 4 (cancer surgery), Cluster 5 (elderly and frailty), Cluster 6 (neuromuscular scoliosis).ConclusionThe relationship between sarcopenia and surgery was still a controversial and well-discussed topic in recent years. Our study showed that the study in this field mainly focused on sarcopenia, oncology surgery, orthopedics, and nutrition.

show abstract

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of research trends in relationship between sarcopenia and surgery

Liu

Song

et al. 2023

Front. Surg.

View full text Add to dashboard Cite

show abstract

“…Studies have shown that combining SII with PNI to form a SII-PNI score can more fully reflect a patient's immune status. We found that to date, only four studies have reported on SII-PNI score predicting treatment outcomes in patients with gastric cancer and urothelial carcinoma (21)(22)(23)(24). They found that pre-treatment SII-PNI score was an important indicator of chemotherapy sensitivity in gastric cancer and urothelial carcinoma patients treated with combination therapy.…”

Section: Discussionmentioning

confidence: 99%

“…SII and PNI are two economical, readily available, and widely used hematological indexes. And the SII-PNI score, as a derivative index of them, can comprehensively reflect the immune status of patients and has been used to evaluate the prognosis of patients with gastric cancer (21)(22)(23)(24). However, their clinical significance in patients with advanced NSCLC is not clear.…”

Section: Introductionmentioning

confidence: 99%

Combined systemic immune-inflammatory index and prognostic nutritional index predict outcomes in advanced non-small cell lung cancer patients receiving platinum-doublet chemotherapy

Fan

Chen

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

BackgroundSystemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) could evaluate the therapeutic efficacy and prognosis in different tumors. However, no studies investigated the SII-PNI score to predict outcomes in non-small cell lung cancer (NSCLC) patients treated with platinum-doublet chemotherapy. The aim of this study was to investigate the SII-PNI score in predicting outcomes in non-small cell lung cancer (NSCLC) patients treated with platinum-doublet chemotherapy.Materials and methodsOur study retrospectively analyzed clinical data from 124 patients with advanced NSCLC receiving platinum-doublet chemotherapy. The SII and PNI were calculated based on peripheral blood cell counts and serum albumin, and the optimal cut-off values were determined using receiver operating characteristic (ROC). All patients were divided into three groups according to the SII-PNI score. The association between the SII-PNI score and the clinicopathological characteristics of the patients was examined. The Kaplan-Meier and Cox regression models were used to assess progression-free survival (PFS)and overall survival (OS).ResultsThere was no significant correlation between SII, PNI at baseline and chemotherapy response in patients with advanced NSCLC (p>0.05). However, after receiving 4 cycles of platinum-doublet chemotherapy, the SII of the SD group (p=0.0369) and PD group (p=0.0286) was significantly higher than that of the PR group. At the same time, the PNI of the SD group (p=0.0112) and the PD group (p=0.0007) was significantly lower than that of the PR group. The PFS of patients with SII-PNI scores of 0, 1, and 2 were 12.0, 7.0, and 5.0 months, and the OS of patients with SII-PNI scores of 0, 1, and 2 were 34.0, 17.0, and 10.5 months, respectively. There was statistical significance among the three groups (all p <0.001). Multivariate analyses showed that the chemotherapy response of progressive disease (PD) (HR, 3.508; 95% CI, 1.546-7.960; p=0.003) and SII-PNI score of 2 (HR, 4.732; 95% CI, 2.561-8.743; p < 0.001) were independently associated with a shorter OS. The uses of targeted drugs (HR, 0.543; 95% CI, 0.329-0.898; p=0.017) and immune checkpoint inhibitors (HR, 0.218; 95% CI, 0.081-0.584; p=0.002) were protective factors for OS in patients with NSCLC.ConclusionCompared with baseline parameters, the correlation between SII, PNI after 4 cycles of chemotherapy and the chemotherapy effect was more significant. The SII-PNI score after 4 cycles of chemotherapy is an effective prognostic biomarker for advanced NSCLC patients treated with platinum-doublet chemotherapy. Patients with a higher SII-PNI score had a worse prognosis.

show abstract

“…Here, we introduce the systemic immune-inflammation index (SII), which is a combination of neutrophil, lymphocyte, and platelet counts in blood. Also, it has been widely investigated and shown to be a useful prognostic indicator in various solid tumors including hepatocellular carcinoma ( 10 ), small cell lung cancer ( 11 ), gastroesophageal adenocarcinoma ( 12 , 13 ), renal cell carcinoma ( 14 ), and prostate cancer ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of the systemic immune-inflammation index for patients with bladder cancer after radical cystectomy

Zhang

Zhong

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

BackgroundBiomarkers acquired from blood samples are easy to obtain and cost-effective, have attracted considerable interest, and have been widely investigated. Inflammation plays a crucial role in cancer cell initiation, proliferation, and metastasis. We aimed to evaluate the association of the preoperative systemic immune-inflammation index (SII) with the clinical outcomes of patients diagnosed with bladder cancer and who underwent radical cystectomy (RC).Materials and methodsData from patients diagnosed with bladder cancer and who underwent RC from December 2010 to May 2020 in West China Hospital were retrospectively collected according to the inclusion and exclusion criteria. Patients were divided into a low-SII group and a high-SII group according to the SII level. Survival outcomes were obtained during follow-up. The primary endpoints were overall survival (OS) and recurrence-free survival (RFS). Cox proportional hazard models were performed to estimate the effect of SII on OS and RFS and control for potential confoundings. Subgroup analyses were conducted, and the log likelihood ratio test was used to inspect the interaction.ResultsA total of 725 patients who underwent RC were ultimately involved in this study. Of these patients, 621 (85.66%) were men and 104 (14.34%) were women. The median age was 65 years. The median follow-up was 36 months for OS and 33.6 months for RFS. The optimal cutoff value was identified as 554.23 × 109/l. A total of 467 (64.41%) patients were divided into the low-SII group (SII <554 × 109/l), and 258 (35.59%) patients were divided into the high-SII group (SII ≥554 × 109/l) accordingly. Multivariable Cox proportional hazard regression demonstrated that a high SII was an independent prognostic factor for worse OS (HR: 1.69 95% CI: 1.02–2.81, P = 0.0436) and RFS (HR: 1.88, 95% CI: 1.09–3.24, P = 0.0229) in NMIBC patients. A high SII was found to be an independent prognostic factor for worse RFS in patients with HBP (HR: 2.11, 95% CI: 1.34–3.30, P = 0.0012), with DM (HR: 3.76, 95% CI: 1.73–8.15, P = 0.0008), and without PNI (HR: 1.32, 95% CI: 1.04–1.69, P = 0.0238).ConclusionsThe SII was a potential prognostic predictor for bladder cancer patients who underwent RC. Further prospective multicenter investigations are warranted.

show abstract

Combined systemic inflammatory immunity index and prognostic nutritional index scores as a screening marker for sarcopenia in patients with locally advanced gastric cancer

Cited by 15 publications

References 54 publications

Bibliometric analysis of research trends in relationship between sarcopenia and surgery

Bibliometric analysis of research trends in relationship between sarcopenia and surgery

Combined systemic immune-inflammatory index and prognostic nutritional index predict outcomes in advanced non-small cell lung cancer patients receiving platinum-doublet chemotherapy

The prognostic value of the systemic immune-inflammation index for patients with bladder cancer after radical cystectomy

Contact Info

Product

Resources

About