Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour

Tytherleigh, M. G.; Birtle, Alison; Cohen, Charlotte; Glynne-Jones, R.; Livingstone, J. I.; Gilbert, Jennifer L.

doi:10.1016/s1479-666x(06)80114-9

Cited by 39 publications

(44 citation statements)

References 27 publications

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“…Treatment for anal warts includes fulguration and excision, cryotherapy, and application of ointments such as podophyllin and imiquimod 5%. However, there is little guidance as to the optimal management of Buschke-Löwenstein tumor because of its rarity [4][5][6][7][13][14][15][16][17][18][19][20][21][22]. Furthermore, the management of AIN is evolving without widely accepted standard of care [1,[8][9][10][11][12][13][23][24][25][26][27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…And while numerous management options are available to treat such disorders, significant challenges remain in terms of disease recurrence or morbidity of treatment. Furthermore, no standardization of care exists for anal disease such as extensive carcinoma in situ or rare neoplasms such as Buschke-Löwenstein tumor [1,[4][5][6][7][8][9][10][11][12]. The purpose of this study was to review a single-center experience with wide local excision and flap or skin graft wound coverage for patients with Buschke-Löwenstein tumor or extensive circumferential anal carcinoma in situ.…”

Section: Introductionmentioning

confidence: 99%

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Wide local excision for Buschke-Löwenstein tumor or circumferential carcinoma in situ

Abbas

2011

Tech Coloproctol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Wide local excision for Buschke-Löwenstein tumor or circumferential carcinoma in situ

Abbas

2011

Tech Coloproctol

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“…Successful treatment has been described with radiochemotherapy based on 5-fluorouracil/mitomycin [8] and 5-fluorouracil/cisplatin [9]. …”

Section: Discussionmentioning

confidence: 99%

Successful Surgical Management of Giant Condyloma Acuminatum (Buschke-Löwenstein Tumor) in the Genitoanal Region: A Case Report and Evaluation of Current Therapies

Gholam¹,

Enk²,

Hartschuh³

2008

Dermatology

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Giant condyloma acuminatum (GCA; Buschke-Löwenstein tumor) is a human-papillomavirus-induced cauliflower-like tumor of the genitoanal region. It is characterized by its size, capability of local infiltration and high recurrence rate. We report on a 50-year-old patient presenting with a maximum finding of GCA with deep infiltration into the adductor and perineal musculature, the scrotum, the penis and the pararectum. After performing a temporary loop colostomy, the tumor was removed by wide radical excision following plastic reconstruction with a myocutaneous gracilis flap. During a follow-up period of more than 5 years, no recurrence developed. Many treatment strategies (e.g. chemotherapy, radiation) have been published in the literature. Most authors recommend the radical surgical excision, allowing a complete histological examination and assessment of tumor-free resection margins. Despite the benign histological pattern of GCA in most cases, transformations into verrucous carcinoma and squamous-cell carcinoma have been described. In our case, the GCA seems to represent a continuum between normal condyloma acuminatum and an initial verrucous carcinoma.

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“…Radiation therapy for VC is controversial 2,8 . This is because radiation was thought to cause anaplastic transformation with corresponding dedifferentiation and increased rates of metastasis, but a recent report indicates that chemoradiotherapy was effective 16 . However, given the possibility that invasive squamous cell carcinoma can arise from VC, we recommend surgical treatment with histologic margin control in order to make the pathological diagnosis as accurately as possible 17 .…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Verrucous Carcinoma: Revisiting the Definition

et al. 2018

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Verrucous carcinoma (VC) is an uncommon, distinct type of well-differentiated squamous cell carcinoma. Here we present two cases of VC, one arising from the lower leg and the other from genital skin.Case 1, a female patient, aged 95 years, had a brownish verrucous plaque on her right lower leg. Histopathologically, epithelial tumor cells grew pushing the stroma, while the basement membrane was intact. No prominent cellular atypia or hyperchromatin was found. Case 2, a male patient, aged 53 years, had a verrucous plaque at the border between his scrotum and inner aspect of his thigh. A pathological diagnosis of VC was made using an excisional specimen. Making a definitive diagnosis of VC is challenging but crucial. Pathological diagnosis using a small specimen might cause underdiagnosis or overdiagnosis. To avoid this, pertinent pathological diagnosis using an ample specimen is required. We also revisited the definition of VC to precisely understand its nature. (J Nippon Med Sch 2018; 85: 47 50)

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Combined surgery and chemoradiation as a treatment for the Buschke-Löwenstein tumour

Cited by 39 publications

References 27 publications

Wide local excision for Buschke-Löwenstein tumor or circumferential carcinoma in situ

Wide local excision for Buschke-Löwenstein tumor or circumferential carcinoma in situ

Successful Surgical Management of Giant Condyloma Acuminatum (Buschke-Löwenstein Tumor) in the Genitoanal Region: A Case Report and Evaluation of Current Therapies

Two Cases of Verrucous Carcinoma: Revisiting the Definition

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